bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Abstract
Pregnancy
and
motherhood
(parity)
can
have
long-term
effects
on
cognition
brain
aging
in
both
humans
rodents.
Estrogens
are
related
to
cognitive
function
neuroplasticity.
improve
postmenopausal
women,
but
the
evidence
is
mixed,
part
due
differences
hormone
therapy
dose
composition.
In
addition,
past
pregnancy
influences
cognition,
with
earlier
age
of
first
being
associated
poorer
outcomes
aging.
However,
few
studies
examined
specific
features
history
such
as
or
possible
mechanisms
underlying
these
changes.
We
whether
maternal
at
estradiol
treatment
differentially
affected
hippocampal
neuroplasticity,
inflammation,
activation,
middle-age.
Thirteen-month-old
rats
(who
were
nulliparous
(never
mothered)
previously
primiparous
(had
a
litter)
3
months
7
months)
received
daily
injections
(or
sesame
oil
vehicle)
for
sixteen
days
tested
Morris
Water
Maze.
An
older
was
impaired
spatial
memory
improved
performance
reversal
training,
increased
new
neurons
ventral
hippocampus
compared
other
groups.
Estradiol
decreased
total
activation
percent
dorsal
hippocampus,
regardless
parity
history.
also
production
anti-inflammatory
cytokines
based
pregnancy.
This
work
suggests
that
affects
neuroplasticity
neuroinflammation
middle
age,
long
lasting
structure
function.
Nature Neuroscience,
Год журнала:
2024,
Номер
27(11), С. 2253 - 2260
Опубликована: Сен. 16, 2024
Abstract
Pregnancy
is
a
period
of
profound
hormonal
and
physiological
changes
experienced
by
millions
women
annually,
yet
the
neural
unfolding
in
maternal
brain
throughout
gestation
are
not
well
studied
humans.
Leveraging
precision
imaging,
we
mapped
neuroanatomical
an
individual
from
preconception
through
2
years
postpartum.
Pronounced
decreases
gray
matter
volume
cortical
thickness
were
evident
across
brain,
standing
contrast
to
increases
white
microstructural
integrity,
ventricle
cerebrospinal
fluid,
with
few
regions
untouched
transition
motherhood.
This
dataset
serves
as
comprehensive
map
human
gestation,
providing
open-access
resource
for
imaging
community
further
explore
understand
brain.
Exercise and Sport Sciences Reviews,
Год журнала:
2024,
Номер
52(2), С. 54 - 62
Опубликована: Фев. 8, 2024
Males
and
females
experience
different
trajectories
of
neuromuscular
function
across
the
lifespan,
with
demonstrating
accelerated
deconditioning
in
later
life.
We
hypothesize
that
menopause
is
a
critical
period
female
during
which
dramatic
reduction
sex
hormone
concentrations
negatively
impacts
synaptic
input
to
motoneuron
pool,
as
well
motor
unit
discharge
properties.
Psychological Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 14, 2025
Racial,
ethnic,
and
socioeconomic
disparities
persist
in
posttraumatic
stress
disorder
(PTSD),
which
are
partly
attributed
to
minoritized
women
being
trauma-exposed,
while
also
contending
with
harmful
contextual
stressors.
However,
few
have
used
analytic
strategies
that
capture
the
interplay
of
these
experiences
their
relation
PTSD.
The
current
study
a
person-centered
statistical
approach
examine
heterogeneity
trauma
exposure,
associations
PTSD
underlying
symptom
dimensions,
diverse
sample
low-income
postpartum
women.
Using
community-based
Black,
Hispanic/Latina,
White
recruited
from
five
U.S.
regions
(n
=
1577),
latent
class
analysis
generated
profiles
past-year
exposure
traumatic
events
at
one
month
postpartum.
Regression
analyses
then
examined
between
membership
severity
six
months
as
function
race/ethnicity.
A
four-class
solution
best
fit
data,
yielding
High
Contextual
Stress,
Injury/Illness,
Violence
Exposure,
Low
Trauma/Contextual
Stress
classes.
Compared
class,
any
other
classes
was
associated
greater
across
nearly
all
dimensions
(all
ps
<
0.05).
Additionally,
constellations
exposures
were
differentially
linked
total
severity,
reexperiencing,
numbing
symptoms
racial/ethnic
groups
(ps
can
diverse,
Moreover,
racially/ethnically
patterned
links
or
stressful
implications
for
screening
intervention
perinatal
period.
Pregnancy
is
marked
by
robust
changes,
including
brain
changes
to
volume,
structure,
connectivity
and
neuroplasticity.
Although
some
are
restricted
pregnancy
the
postpartum,
others
long-lasting.
Few
studies
have
examined
possible
mechanisms
of
these
or
effects
multiple
pregnancies.
We
characterized
various
cellular
molecular
signatures
parity
(nulliparous,
primiparous,
biparous)
in
rat
hippocampus.
investigated
density
neural
stems
cells
(Sox2),
microglia
(Iba-1)
levels
a
synaptic
protein
(PSD-95),
cell
signalling
pathways,
neuroinflammation,
tryptophan-kynurenine
(TRP-KYN)
pathway,
one
week
after
weaning
their
pups
from
last
(age
dam:
seven
months)
middle-age
13
months).
Parity
increased
PSD-95
both
age
groups
prevented
age-related
decrease
stem
observed
nulliparous
rats.
Biparity
phosphoproteins
(pp70S6K,
S6RP)
number
dentate
gyrus,
regardless
age.
resulted
transient
TRP-KYN
system.
Thus,
previous
has
lasting
on
plasticity
with
fewer
inflammation
whole
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 15, 2023
Pregnancy
is
a
period
of
profound
hormonal
and
physiological
change
experienced
by
millions
women
annually,
yet
the
neural
changes
unfolding
in
maternal
brain
throughout
gestation
have
not
been
studied
humans.
Leveraging
precision
imaging,
we
mapped
neuroanatomical
an
individual
from
preconception
through
two
years
postpartum.
Pronounced
decreases
gray
matter
volume
cortical
thickness
were
evident
across
brain,
which
stand
contrast
to
increases
white
microstructural
integrity,
ventricle
volume,
cerebrospinal
fluid,
with
few
regions
untouched
transition
motherhood.
This
dataset
serves
as
first
comprehensive
map
human
gestation,
providing
open-access
resource
for
imaging
community
stimulate
further
exploration
discovery.
Psychoneuroendocrinology,
Год журнала:
2024,
Номер
165, С. 107040 - 107040
Опубликована: Апрель 2, 2024
Recent
research
shows
prominent
effects
of
pregnancy
and
the
parenthood
transition
on
structural
brain
characteristics
in
humans.
Here,
we
present
a
comprehensive
study
how
parental
status
number
children
born/fathered
links
to
markers
cellular
ageing
36,323
UK
Biobank
participants
(age
range
44.57
-
82.06
years;
52%
female).
To
assess
global
parenting
brain,
trained
3D
convolutional
neural
network
T1-weighted
magnetic
resonance
images,
estimated
age
held-out
test
set.
investigate
regional
specificity,
extracted
cortical
subcortical
volumes
using
FreeSurfer,
ran
hierarchical
clustering
group
based
covariance.
Leukocyte
telomere
length
(LTL)
derived
from
DNA
was
used
as
marker
ageing.
We
employed
linear
regression
models
relationships
between
children,
age,
volumes,
LTL,
included
interaction
terms
probe
sex
differences
associations.
Lastly,
measures
LTL
features
binary
classification
models,
determine
if
could
predict
status.
The
results
showed
associations
greater
younger
both
females
males,
with
stronger
observed
females.
Volume-based
analyses
maternal
striatal
limbic
regions,
which
were
not
evident
fathers.
found
no
evidence
for
LTL.
Classification
an
Area
under
ROC
Curve
(AUC)
0.57
model,
while
predictors
AUCs
0.52.
Our
findings
align
previous
population-based
studies
middle-
older-aged
parents,
revealing
subtle
but
significant
experience
neuroimaging-based
surrogate
health.
further
corroborate
longitudinal
cohort
following
parents
across
postpartum,
potentially
indicating
that
is
associated
long-term
influences
