WTools: A MATLAB-based toolbox for time-frequency analysis of infant data

PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0323179 - e0323179

Опубликована: Май 7, 2025

Electroencephalography (EEG) is an established method for investigating neurocognitive functions during human development. In cognitive neuroscience, time-frequency analysis of the EEG a widely used analytical approach. This paper introduces WTools, new MATLAB-based toolbox signals using complex wavelet transformation. WTools features intuitive GUI that guides users through steps, focusing on essential parameters. Being free and open-source, it can be integrated expanded with features, making handy tool growing its popularity in developmental neuroscience. While default settings follow pipelines research, also provides flexibility to accommodate more commonly adult Here, we provide detailed description algorithm transformation compare state-of-the-art methods implemented EEGLAB. Alongside official release, offer comprehensive, illustrated tutorial sample infant data designed support novice users, enhance accessibility promote transparent reproducible usage WTools.

Язык: Английский

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Contribution of membrane-associated oscillators to biological timing at different timescales

Frontiers in Physiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

Environmental rhythms such as the daily light-dark cycle selected for endogenous clocks. These clocks predict regular environmental changes and provide basis well-timed adaptive homeostasis in physiology behavior of organisms. Endogenous are oscillators that based on positive feedforward negative feedback loops. They generate stable even under constant conditions. Since weak interactions between allow autonomous synchronization, coupling/synchronization provides self-organized physiological timing. Amongst most thoroughly researched circadian clock neurons mammals insects. comprise nuclear clockworks transcriptional/translational loops (TTFL) ∼24 h gene expression entrained to day-night cycle. It is generally assumed this TTFL clockwork drives all oscillations within cells, being any rhythm Instead current gene-based hierarchical model we here a systems view We suggest coupled system posttranslational loop (PTFL) oscillators/clocks run at multiple timescales governs adaptive, dynamic behavior. focus mammalian insect timescales. neuronal plasma membrane-associated signalosomes constitute specific PTFL localized but interlinked membrane potential intracellular messengers with frequencies. In each neuron multiscale form temporally structured oscillatory network common complex frequency-band comprising superimposed oscillations. Coupling oscillator/clock next level complexity an network. This systemic molecular cellular suggested cycles through homeostatic setpoints characteristic hallmark. propose mechanisms plasticity maintain stability these setpoints, whereas Hebbian enables switching via coupling factors, like biogenic amines and/or neuropeptides. reprogram new frequency, setpoint. Our novel hypothesis up experimental challenge.

Язык: Английский

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Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting

Pharmacological Reviews, Год журнала: 2024, Номер 76(6), С. 1291 - 1325

Опубликована: Июль 16, 2024

Over 4 decades of research support the link between Alzheimer disease (AD) and somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF SRIF-expressing neurons play an essential role in brain function, modulating hippocampal activity memory formation. Loss rests at center a series interdependent pathological events driven by amyloid-β peptide (Aβ), culminating cognitive decline dementia. The connection AD further extends to neuropsychiatric symptoms, seizure activity, inflammation, whereas preclinical investigations show or receptor agonist administration capable enhancing cognition. subtype-4 activation particular presents unique attributes, with potential mitigate learning decline, reduce comorbid enhance enzymatic degradation Aβ brain. Here, we review links along therapeutic implications. SIGNIFICANCE STATEMENT: Somatostatin somatostatin-expressing are extensively involved contributing Targeting somatostatin-mediated processes has significant for treatment disease.

Язык: Английский

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The safety and effectiveness of 40 Hz γ-tACS in Alzheimer's disease: A meta-analysis

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 102(2), С. 295 - 307

Опубликована: Окт. 29, 2024

The efficacy and safety of 40 Hz gamma transcranial alternating current stimulation (γ-tACS) in Alzheimer's disease (AD) are still uncertain.

Язык: Английский

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Hippocampal-prefrontal high-gamma flow during performance of a spatial working memory

Brain Research Bulletin, Год журнала: 2024, Номер 207, С. 110887 - 110887

Опубликована: Янв. 26, 2024

Working memory refers to a system that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. The prefrontal cortex (PFC) hippocampus (HPC) are major structures contributing working memory. Accumulating evidence suggests HPC-PFC interactions critical successful execution Nevertheless, directional transmission within pathway remains unclear. Using simultaneous multi-electrode recordings, we recorded local field potentials (LFPs) from medial (mPFC) ventral (vHPC) while rats performed spatial task in Y-maze. directionality functional between mPFC vHPC was assessed using phase-slope index (PSI). Our findings revealed frequency-specific oscillatory synchrony two regions during task. Furthermore, an increased high-gamma flow manifested exclusively correctly trials, not observed incorrect ones. This enhanced reflects behavioral performance Consequently, our results indicate role communication hippocampal-frontal circuit memory, providing potential mechanism

Язык: Английский

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The role of theta and gamma oscillations in item memory, source memory, and memory confidence

Psychophysiology, Год журнала: 2024, Номер 61(9)

Опубликована: Май 7, 2024

Abstract Theta and gamma oscillations have been linked to episodic memory processes in various studies. Both seem be vital for guided by the medial temporal lobe, such as retrieval of information from memory. While theta increase with successful memory, it is unclear what unique contribution subcomponents On other hand, memory‐related mainly reported hippocampus, leaving role neocortical underexplored. In this study, we investigated how variability accuracy confidence contributes fluctuations power. To end, recorded EEG 54 participants while they performed a source task. From task obtained their item accuracy, confidence, confidence. These behavioral measures were put trial‐by‐trial linear mixed effects model uncover oscillatory power frontal parietal regions. Our results are line involvement both but indicate main addition, found that play roles processing, dependent on brain region.

Язык: Английский

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Synchronization of the prefrontal cortex with the hippocampus and posterior parietal cortex is navigation strategy-dependent during spatial learning

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 15, 2024

1. ABSTRACT During goal-directed spatial learning, subjects progressively change their navigation strategies to increase efficiency, an operation supported by the medial prefrontal cortex (mPFC). However, how mPFC may integrate relevant information in a wider memory networks involving hippocampus (HPC) and posterior parietal (PPC) is poorly understood. We recorded local-field potential neuronal firing simultaneously from mPFC, HPC PPC mice subjected acquisition Barnes maze. trials, animals demonstrated two consecutive behavioral stages: searching exploration. Throughout training, gradually switched less efficient (non-spatial) more (spatial) goal-oriented exclusively during stage. 4-Hz theta (6-12 Hz) oscillations were detected three areas associated with episodes of immobility locomotion, respectively. The entrainment gamma (60-100 hippocampal oscillations, as well incidence gamma, was higher when implemented Interestingly, also synchronized spike-timing neurons, which maximum Finally, neurons increased task stage selectivity they used strategy. Altogether, these results provide evidence for neural mechanisms underlying large-scale coordination distributed learning.

Язык: Английский

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Rhythmic sensory stimulation as a noninvasive tool to study plasticity mechanisms in human episodic memory

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 58, С. 101412 - 101412

Опубликована: Май 29, 2024

In recent years, research in animals has increasingly focused on understanding the role of precise neural timing inducing synaptic plasticity (the strengthening or weakening connections). Human episodic memory is thought to depend such plasticity. Animal studies have provided valuable insights into mechanisms as spike-timing-dependent and theta-phase-dependent plasticity, highlighting importance coordinated between inputs for changes occur. Building upon these findings, employing rhythmic sensory stimulation electromagnetic humans attempted link formation. These revealed that consolidation relies co-ordination inputs, particularly gamma theta frequency ranges. This body work represents a crucial bridge our cellular-level animal models complex processes underlying human memory.

Язык: Английский

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Dendritic spine head diameter predicts episodic memory performance in older adults

Science Advances, Год журнала: 2024, Номер 10(32)

Опубликована: Авг. 7, 2024

Episodic memory in older adults is varied and perceived to rely on numbers of synapses or dendritic spines. We analyzed 2157 neurons among 128 individuals from the Religious Orders Study Rush Memory Aging Project. Analysis 55,521 individual spines by least absolute shrinkage selection operator regression nested model cross-validation revealed that spine head diameter temporal cortex, but not premotor improved prediction episodic performance models containing β amyloid plaque scores, neurofibrillary tangle pathology, sex. These findings support emerging hypothesis that, synapse strength more critical than quantity for old age.

Язык: Английский

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Repeated exposure to novelty promotes resilience against the amyloid-beta effect through dopaminergic stimulation

Psychopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 15, 2024

Abstract Rationale The accumulation of beta-amyloid peptide (Aβ) in the forebrain leads to cognitive dysfunction and neurodegeneration Alzheimer's disease. Studies have shown that individuals with a consistently cognitively active lifestyle are less vulnerable Aβ toxicity. Recent research has demonstrated intrahippocampal can impact catecholaminergic release spatial memory. Interestingly, exposure novelty stimuli been found stimulate catecholamines hippocampus. However, it remains uncertain whether repeated enhancing catecholamine activity effectively alleviate impairment Objectives Our primary aim was investigate could enable resilience against Aβ. This protection be achieved by modulating within Methods To this hypothesis, we subjected mice three different conditions—standard housing (SH), (Nov), or daily social interaction (Soc) for one month. We then infused saline solution (SS) (Aβ 1-42 ) oligomers intrahippocampally measured memory retrieval Morris Water Maze (MWM). Stereological analysis extracellular baseline dopamine levels using vivo microdialysis were assessed independent groups mice. Results received infusions remained SH Soc conditions showed impaired retrieval. In contrast, animals Nov protocol remarkable resilience, showing strong expression even after infusion. stereological indicated infusion reduced tyrosine hydroxylase axonal length compared group. Accordingly, hippocampal increased significantly groups. Conclusions These compelling results demonstrate potential strengthen dopaminergic system mitigate toxic effects . They also highlight new promising therapeutic avenues treating preventing AD, especially its early stages.

Язык: Английский

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