Cited by How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration

βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells DOI

Sujan Chatterjee,

Sayan Ghosh,

Zachary Sin

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

The retinal pigmented epithelial (RPE) cells maintain homeostasis, and alterations in their function contribute to non-exudative age-related macular degeneration (AMD)

Язык: Английский

Процитировано

Protective effect of zinc against A2E-induced toxicity in ARPE-19 cells: Possible involvement of lysosomal acidification DOI

Jeong A Choi,

Bora Seo,

Jae-Young Koh

и другие.

Heliyon, Год журнала: 2024, Номер 10(21), С. e39100 - e39100

Опубликована: Окт. 11, 2024

A key pathogenic mechanism of dry age-related macular degeneration (AMD) is lysosomal dysfunction in retinal pigment epithelium (RPE) cells, which results the accumulation lipofuscins such as A2E (N-retinylidene-N-retinylethanolamine) that further compromises function. This vicious cycle leads to cell death and poor visual acuity. Here, we established an

Язык: Английский

Процитировано

Lysosome‐Targeted Bifunctional Fluorescent Probe and Type I/II Photosensitizer for Viscosity Imaging and Cancer Photodynamic Therapy DOI

Du Liu,

Hongyan An,

Xianglong Li

и другие.

Luminescence, Год журнала: 2024, Номер 39(11)

Опубликована: Ноя. 1, 2024

Abnormal lysosomal viscosity is closely associated with cancer progression, underscoring the need for bifunctional fluorescent probes and photosensitizers (PSs) that can both monitor facilitate imaging-guided therapy simultaneous diagnosis treatment. Despite advances in lysosome-targeted PSs development, few have demonstrated ability to generate Type I II reactive oxygen species (ROS). In this study, we present BTTPA, a probe photosensitizer, designed integrate via imaging treatment through photodynamic (PDT). Our findings reveal BTTPA selectively targets lysosomes, enabling dynamic monitoring of cellular distinguishing cells from normal cells. Upon light activation, efficiently generates ROS. Apoptosis assays further confirm BTTPA's effectiveness inducing cell apoptosis, highlighting its potential as powerful tool therapy.

Язык: Английский

Процитировано

How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration DOI

Aparna Lakkaraju, Patricia Boya, Marie Csete

и другие.

Experimental Eye Research, Год журнала: 2024, Номер unknown, С. 110219 - 110219

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано