A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Nature Neuroscience, Год журнала: 2024, Номер 27(11), С. 2138 - 2151

Опубликована: Сен. 18, 2024

Язык: Английский

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Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review

Journal of Neurochemistry, Год журнала: 2024, Номер unknown

Опубликована: Июль 8, 2024

Abstract Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance (MRI) biomarker for investigating brain function and composition. This comprehensive review synthesizes the current state of knowledge on MWF human cerebral aging, neurodegenerative diseases, risk factors influencing myelination. The databases used include Web Science, Scopus, Science Direct, PubMed. We begin with brief discussion theoretical foundations imaging, including its basis in MR physics mathematical modeling underlying calculation, an overview most adopted MRI methods imaging. Next, we delve into clinical research applications that have been explored to date, highlighting advantages limitations. Finally, explore potential serve predictive neurological disorders identify future directions optimizing protocols interpreting various contexts. By harnessing power may gain new insights health disease across lifespan, ultimately informing novel diagnostic therapeutic strategies. image

Язык: Английский

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The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders

Life Sciences, Год журнала: 2024, Номер 354, С. 122952 - 122952

Опубликована: Авг. 9, 2024

The bidirectional regulation between the gut microbiota and brain, known as gut-brain axis, has received significant attention. myelin sheath, produced by oligodendrocytes or Schwann cells, is essential for efficient nervous signal transmission maintenance of brain function. Growing evidence shows that both oligodendrogenesis myelination are modulated its metabolites, when dysbiosis occurs, changes in composition and/or associated metabolites may impact developmental occurrence neurodevelopmental disabilities. Although link demyelinating disease such multiple sclerosis been extensively studied, our knowledge about role other myelin-related disorders, neurodegenerative diseases, limited. Mechanistically, microbiota-oligodendrocyte axis primarily mediated factors inflammation, vagus nerve, endocrine hormones, evidenced metagenomics, metabolomics, vagotomy, morphological molecular approaches. Treatments targeting this include probiotics, prebiotics, microbial herbal bioactive compounds, specific dietary management. In addition to commonly used approaches, viral vector-mediated tracing gene manipulation, integrated multiomics multicenter clinical trials will greatly promote mechanistic interventional studies ultimately, development new preventive therapeutic strategies against gut-oligodendrocyte axis-mediated impairments. Interestingly, recent findings showed can be induced hippocampal damage reversible myelin-targeted drugs, which provides insights into understanding how hippocampus-based functional impairment (such Alzheimer's disease) regulates peripheral homeostasis systemic disorders.

Язык: Английский

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Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra

Journal of Neurochemistry, Год журнала: 2025, Номер 169(1)

Опубликована: Янв. 1, 2025

ABSTRACT Parkinson's disease (PD) is a prevalent neurodegenerative caused by the death of dopaminergic neurons within substantia nigra pars compacta (SNpc) region midbrain. Recent genomic and single cell sequencing data identified oligodendrocytes oligodendrocyte precursor cells (OPCs) to confer genetic risk in PD, but their biological role unknown. Although SNpc are scarcely or thinly myelinated, there gap knowledge concerning physiological interactions between oligodendroglia. We sought investigate distribution OPCs with regard myelination state mouse (SN) high‐resolution imaging provide morphological assessment OPC‐dopaminergic neuron quantification numbers across different age groups. evenly distributed midbrain throughout lifespan they physically interact both soma axons neurons. The presence interaction does not correlate myelin. Myelination sparse SNpc, including fibers originating from projecting through reticulata (SNpr). report that exist 1:1 ratio accounting for 15%–16% all This description provides first look at longitudinal mice, suggesting additional functions beyond differentiation into myelinating oligodendrocytes. image

Язык: Английский

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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice

Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106827 - 106827

Опубликована: Фев. 1, 2025

Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited and belongs to family of nine diseases caused by a polyglutamine expansion in disease-causing protein. In SCA3, ATXN3 causes neuron loss disease-vulnerable brain regions, resulting progressive coordination ultimately death. There are no disease-modifying or preventative treatments for this uniformly fatal disorder. Recent studies demonstrate prominent white matter atrophy microstructural alterations regions SCA3 patients mouse models. However, major constituent - lipids remains understudied SCA3. study, we conducted first unbiased investigation focusing on cerebellum postmortem Liquid chromatography-mass spectrometry uncovered widespread lipid reductions with Lipid downregulation was recapitulated early- mid-stage models including transgenic YACQ84 Knock-in Q300 mice. End-stage mice displayed reduction content, highlighting targets that could benefit from early therapeutic intervention. contrast, Atxn3-Knock-out showed mild upregulation, emphasizing toxic gain-of-function mechanism underlying We conclude significantly altered establish platform continued exploration disease through interactive data visualization websites. Pronounced myelin-enriched suggest dysregulation underlie This study establishes basis future work elucidating mechanistic, biomarker, potential

Язык: Английский

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Effects of trace element dysregulation on brain structure and function in spinocerebellar Ataxia type 3

Neurobiology of Disease, Год журнала: 2025, Номер 207, С. 106816 - 106816

Опубликована: Фев. 6, 2025

Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by excess CAG repeats in the ATXN3 gene, leads to progressive cerebellar and other symptoms. The results of previous studies suggest that trace element dysregulation contributes onset. Here, we investigated relationships with repeat length, clinical severity, brain structural functional connectivity 45 patients SCA3 44 healthy controls (HCs). Blood levels lithium (Li), selenium (Se), copper (Cu) were significantly lower than HCs; Li Se negatively correlated especially manifest subgroup. Diffusion tensor imaging combined resting-state magnetic resonance revealed fractional anisotropy white matter (WM) bilateral frontal parietal regions; tractography mapping showed Li-associated region nerve fiber pathways SCA3. Dynamic causal modeling analyses bidirectional from inferior lobule(IPL) cerebellum was blood level Time series correlation-based analysis intrinsic connectivities dorsal premotor cortex(PMd) IPL local regions weaker HCs. Our dysregulation, deficiency, induces alterations manifestations SCA3; supplementation may be beneficial for WM or astrocytes this patient population.

Язык: Английский

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Cerebellar Pathology in Forensic and Clinical Neuroscience

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102697 - 102697

Опубликована: Фев. 1, 2025

Язык: Английский

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Neuroinflammation: An Oligodendrocentric View

Glia, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Chronic neuroinflammation, driven by central nervous system (CNS)-resident astrocytes and microglia, as well infiltration of the peripheral immune system, is an important pathologic mechanism across a range neurologic diseases. For decades, research focused almost exclusively on how neuroinflammation impacted neuronal function; however, there accumulating evidence that injury to oligodendrocyte lineage component for both clinical outcomes. While oligodendrocytes are able undergo endogenous repair process known remyelination, this becomes inefficient usually fails in presence sustained inflammation. The present review focuses our current knowledge regarding activation innate adaptive systems chronic demyelinating disease, multiple sclerosis, provides other conditions, such perinatal white matter injury, traumatic brain viral infections, converges injury. Lastly, therapeutic potential targeting impact inflammation these diseases discussed.

Язык: Английский

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Evaluation of focused ultrasound modulation of the blood-brain barrier in gray and white matter

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113631 - 113631

Опубликована: Март 1, 2025

Язык: Английский

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Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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