Reverse-engineering placebo analgesia

Current Biology, Год журнала: 2024, Номер 34(18), С. 4261 - 4271.e5

Опубликована: Сен. 1, 2024

Язык: Английский

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Diffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 402 - 402

Опубликована: Янв. 5, 2025

Diffuse noxious inhibitory control (DNIC), also known as conditioned pain modulation (CPM) in humans, is a paradigm wherein the heterotopic application of stimulus results attenuation another spatially distant input. The pre-clinical and clinical studies show involvement several neurochemical systems DNIC/CPM point to major contribution noradrenergic, serotonergic, opioidergic systems. Here, we thoroughly review latest data on monoaminergic studies, focusing particularly models chronic pain. We conduct an in-depth analysis these by integrating available with descending modulatory circuits therein bring light mechanisms involved regulation DNIC. most recent suggest that DNIC may have dual outcome encompassing not only analgesic effects but hyperalgesic effects. This duality might be explained underlying circuitry receptor subtypes therein. Acknowledging this contribute validating prognostic nature paradigm. Additionally, serve robust predictive value for guiding treatment through more effective targeting modulation.

Язык: Английский

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An intra-brainstem circuitry for pain-induced inhibition of itch

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Differential Neuronal Activation of Nociceptive Pathways in Neuropathic Pain After Spinal Cord Injury

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Янв. 30, 2025

Neuropathic pain, a prevalent complication following spinal cord injury (SCI), severely impairs the life quality of patients. No ideal treatment exists due to incomplete knowledge on underlying neural processes. To explore SCI-induced effect nociceptive circuits, protein expression c-Fos was analyzed as an indicator neuronal activation in rat contusion model exhibiting below-level pain. Additional stimuli were delivered mimic different peripheral sensory inputs daily life. Following noxious rather than innocuous or no stimulation, greater number dorsal horn (DH) neurons activated after SCI, mainly deep DH. SCI facilitated excitatory but not inhibitory DH neurons. Moreover, interneurons expressing kinase C gamma (PKCγ) laminae II–III, which are known play role mechanical allodynia nerve injury, responded larger amounts both and stimulation SCI. Accordingly, more projection lamina I activated. Within supraspinal nuclei processing differentially enhanced response detected with significant increase locus coeruleus medial thalamus, slight periaqueductal gray raphe, change lateral parabrachial nucleus primary cortex. These findings indicated differential hyperexcitability along neuroaxis particular emphasis involvement specific neuron subtypes, such PKCγ noradrenergic neurons, may serve crucial targets for potential therapies. Rats pain like behavior showed increased engagement subtypes activity nuclei. The figure created using Figdraw 2.0.

Язык: Английский

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Single-nucleus RNA sequencing of rostral ventromedial medulla in mice with trigeminal neuralgia

International Journal of Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Май 2, 2025

To investigate the transcriptional changes and cell interactions following trigeminal neuralgia in different types rostral ventromedial medulla (RVM). In present study, neuropathic pain was induced mice by ligating left infraorbital nerve. Ten days after nerve ligation, we performed single-nucleus RNA sequencing of RVM cells from Sham TN (trigeminal neuralgia) groups. We identified neurons, astrocytes, microglial cells, oligodendrocytes, oligodendrocyte progenitor Purkinje neuroblasts, endothelial fibroblasts tissue. After analyzing cell-type-specific found that number neurons increased. Furthermore, differentially expressed genes (DEGs) astrocytes between two groups identified. The downregulated DEGs were significantly enriched GABAergic synapse (such as Gabrg3 Gabra2). upregulated glutamatergic voltage-gated ion channels. involved regulation postsynaptic membrane synaptic enriched. Notably, CellChat analysis highlights Slit2-Robo 1/2 signaling pathway a key route communication ligation. study analyzed responses to pain, possible neuralgia. inferred cell-state-specific various types. Our findings provide potential targets such 1/2, Gabrg3, Gabra2, Grm4, Grik2, Cadps2 Camk4 on therapeutic strategies for or orofacial pain.

Язык: Английский

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Reduction of opioid withdrawal symptoms and opioid-induced hyperalgesia by subcutaneous sumatriptan reveals central neuromodulation

Journal of Pain, Год журнала: 2025, Номер unknown, С. 105456 - 105456

Опубликована: Июнь 1, 2025

Язык: Английский

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Neuroanatomy of the nociceptive system: From nociceptors to brain networks

International review of neurobiology, Год журнала: 2024, Номер unknown, С. 1 - 39

Опубликована: Янв. 1, 2024

Язык: Английский

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Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.

Pain, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

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The irreversible, towards fatalic neuropathy: from the genesis of diabetes

Acta Diabetologica, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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