Jornal de Pediatria, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Nature, Год журнала: 2025, Номер 637(8046), С. 536 - 538
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Developmental Cognitive Neuroscience, Год журнала: 2025, Номер 73, С. 101538 - 101538
Опубликована: Фев. 28, 2025
Air pollution affects human health and may disrupt brain maturation, including axon myelination, critical for efficient neural signaling. Here, we assess the impact of prenatal current long-term particulate matter (PM) nitrogen dioxide (NO2) exposure on cortical T1w/T2w ratios - a proxy myelin content in school-age children from Adolescent Brain Cognitive Development (ABCD) Study (United States; N = 2021) NeuroSmog study (Poland; 577), using Siemens scanners. Across both samples, found that NO2 PM were not significantly associated with except one association PM10 lower precuneus NeuroSmog. Superficially, ABCD analyses data all scanner types (Siemens, GE, Philips; 3089) revealed negative between NO₂ ratios. However, this finding could be an artifact between-site sociodemographic differences large scanner-type-related measurement differences. While significant associations air largely absent, these findings do rule out possibility during other periods/stages neurodevelopment. Future research should examine relationships across diverse populations developmental periods unified analysis methods to better understand potential neurotoxic effects pollution.
Язык: Английский
Процитировано
0
Environmental Research, Год журнала: 2025, Номер unknown, С. 121368 - 121368
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Toxicology, Год журнала: 2025, Номер unknown, С. 154052 - 154052
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Abstract Background Residential segregation is associated with differential exposure to air pollution. Hippocampus structure and function are highly susceptible pollutants posttraumatic stress disorder (PTSD) development. Therefore, we investigated associations between residential segregation, pollutants, hippocampal neurobiology, PTSD in recent trauma survivors. Methods Participants ( N = 278; 34% non-Hispanic white, 46% Non-Hispanic Black, 16% Hispanic) completed multimodal neuroimaging two weeks after trauma. Yearly averages of (PM 2.5 NO 2 ) racial/economic (Index Concentration at the Extremes) were derived from each participant’s address. Linear models assessed if mediated volume, threat reactivity, or parahippocampal cingulum fractional anisotropy (FA) covarying for age, sex, income, 2-week symptoms. Further evaluated prospectively predicted symptoms six months post-trauma. Results Black participants lived neighborhoods significantly greater pollution compared Hispanic white ps <.001). There was a significant indirect effect FA values (β 0.08, 95% CI[0.01, 0.15]), an PM reactivity -0.08, CI[-0.14, -0.01]). no direct on features. Pollutants not Conclusion exposure, which turn variability features among research needed assess relationships other environmental factors stress-related disorders.
Язык: Английский
Процитировано
0
Chemical Research in Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Despite the popularity of electronic cigarettes (e-cigs) among adolescent and youth never-smokers adult smokers seeking a less harmful substitute for tobacco cigarettes, long-term health impact vaping is largely unknown. Biochemical, molecular, toxicological analyses biospecimens from e-cig users as well assays in relevant vitro models silico studies can identify chemical constituents emissions that may contribute to disease-causing potential vaping. E-cig aerosol contains wide range toxic carcinogenic compounds, which metals are particular concern. This due known or suspected role various pathogenesis numerous diseases. Many metalloids (herein referred "metals") have been detected liquid (e-liquid) and/or cells, tissues, biofluids, other specimens users. Metals contaminate ingredients e-liquid corrode internal components device. also be directly aerosolized surface heating element parts Inhalation metal habitual vapers nonusers through secondary exposure increase body burden chemicals. review summarizes state research on e-cig-derived their contributions estimated risks Highlighting composition aerosol, it focuses contents inhaled associated with this exposure. Emphasis placed adolescents who vulnerable populations bear disproportionate risk harm products. The gaps knowledge, methodological challenges, opportunities ahead discussed. importance translating findings into actionable information used regulation manufacturing products underscored.
Язык: Английский
Процитировано
0
Journal of Child Psychology and Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Humans are inevitably exposed to multiple physical and social environmental risk factors, potentially contributing psychiatric problems cognitive deficits; however, the combined effects of prenatal air pollution psychosocial environments on youth remain unclear. This longitudinal study aimed examine how ozone exposure interacts with at 9-10 years affect adolescent limbic system development, cognition, psychotic-like experiences (PLEs) 11-13 years. We analyzed data from 6,778 participants in Adolescent Brain Cognitive Development (ABCD) Study® two time points (baseline: 2-year follow-up). Prenatal was calculated as a 9-month average daily estimates based birth year address. Social factors included school environment neighborhood safety both points. Structural MRI measures bilateral amygdala hippocampus volumes Behavioral consisted cognition PLEs scores Moderation moderated mediation models cluster-robust standard errors were constructed effects, controlling for covariates. Children who prenatally greater had more unfavorable exhibited smaller increase left hippocampal volume, leading poorer PLEs. Moreover, children lived unsafe larger right volume. is first demonstrate pollutant adverse childhood highlighting an important neural mechanism underlying effects.
Язык: Английский
Процитировано
0
Toxics, Год журнала: 2025, Номер 13(4), С. 284 - 284
Опубликована: Апрель 8, 2025
Air pollution plays a key role in sleep disorders and neurodegeneration. Alzheimer’s disease (AD), Parkinson’s (PD), and/or transactive response DNA-binding protein TDP-43 neuropathology have been documented children young adult forensic autopsies the metropolitan area of Mexico City (MMC), along with disorders, cognitive deficits, MRI brain atrophy seemingly healthy populations. Ultrafine particulate matter (UFPM) industrial nanoparticles (NPs) reach urbanites’ brains through nasal/olfactory, lung, gastrointestinal tract, placental barriers. We Fe UFPM/NPs neurovascular units, as well lateral hypothalamic nucleus orexinergic neurons, thalamus, medullary, pontine, mesencephalic reticular formation, pinealocytes. quantified ferromagnetic materials arousal hubs examined their motion behavior to low magnetic fields MMC autopsy samples from nine 25 adults AD, PD, neuropathology. Saturated isothermal remanent magnetization curves at 50–300 mT were associated UFPM/NP accumulation sleep/awake 30–50 µT (DC fields) exposure. Brain exposed anthropogenic PM found be sensitive fields, behaviors that potentially linked early development progression fatal neurodegenerative diseases disorders. Single-domain orexin system, arousal, sleep, autonomic regions, are neurodegeneration, behavioral impairment, need identify higher risk monitor environmental UFPM NP emissions exposures fields. Ubiquitous ferrimagnetic particles field threat global health.
Язык: Английский
Процитировано
0
Global Public Health, Год журнала: 2025, Номер 20(1)
Опубликована: Апрель 18, 2025
The world's population is rapidly urbanising, especially in low- to middle-income countries. However, urban living associated with an increased risk of neurodevelopmental disorders (NDD) like autism spectrum (ASD) and schizophrenia. Exposure air pollutants particulate matter has been positively both ASD schizophrenia diagnosis rates. Mechanistic studies have shown that exposure leads brain inflammation white pathologies consistent these disorders. Children are susceptible effects due their developing nervous systems. Despite this, few reviews on the subject recommend future steps mitigate teratogenic pollution. This commentary synthesises evidence recommends research policy goals protect children, present future, from consequences These include further study relationship between pollution equitable resource distribution address coming global rises NDD. Furthermore, capacity building urbanising nations essential overcome barriers erected by extraction outsourcing wealthy nations. With such integrated approach, progress can be made protecting systems children generations affluent resource-strained
Язык: Английский
Процитировано
0
Environmental Health Perspectives, Год журнала: 2024, Номер 132(10)
Опубликована: Окт. 1, 2024
Emerging literature suggests that fine particulate matter [with aerodynamic diameter
Язык: Английский
Процитировано
2