Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Cell Metabolism, Год журнала: 2019, Номер 31(1), С. 92 - 104.e5

Опубликована: Дек. 5, 2019

Язык: Английский

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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment

Trends in cancer, Год журнала: 2019, Номер 5(8), С. 475 - 494

Опубликована: Авг. 1, 2019

Язык: Английский

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Role of sleep deprivation in immune-related disease risk and outcomes

Communications Biology, Год журнала: 2021, Номер 4(1)

Опубликована: Ноя. 18, 2021

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects deprivation on Sleep exerts immune-supportive function, promoting host defense against infection inflammatory insults. has been associated alterations innate adaptive immune parameters, leading to a chronic state increased risk infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune neurodegenerative diseases. Here, we review recent advancements responses as evidenced by experimental epidemiological studies, pathophysiology, role deprivation-induced changes in Gaps knowledge methodological pitfalls still remain. Further understanding causal relationship between deregulation would help identify individuals at disease prevent adverse health outcomes.

Язык: Английский

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Circadian disruption: What do we actually mean?

European Journal of Neuroscience, Год журнала: 2018, Номер 51(1), С. 531 - 550

Опубликована: Ноя. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Язык: Английский

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Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Год журнала: 2021, Номер 43(2), С. 405 - 436

Опубликована: Сен. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Язык: Английский

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Cancer and the Circadian Clock

Cancer Research, Год журнала: 2019, Номер 79(15), С. 3806 - 3814

Опубликована: Июль 12, 2019

The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations crucial biological processes and behaviors. Notably, disruption has recently been identified as an independent risk factor for cancer classified carcinogen. As such, it imperative to discern the underpinning mechanisms by which alters risk. Emergent data, reviewed herein, demonstrate that regulatory functions play critical roles in several hallmarks cancer, including control cell proliferation, death, DNA repair, metabolic alteration. Developing deeper understanding circadian-cancer regulation cross-talk holds promise developing new strategies interception, prevention, management.

Язык: Английский

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A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions

LEUKOS The Journal of the Illuminating Engineering Society of North America, Год журнала: 2021, Номер 18(3), С. 387 - 414

Опубликована: Март 26, 2021

Architectural lighting has potent biological effects but applied practices that capitalize on this potential have been limited. In review, we endeavor to consolidate and synthesize key references will be useful for professionals, with the goal of supporting knowledge translation into pragmatic strategies. Specifically, explain relevant terminology, outline basic concepts, identify references, provide a balanced overview current state knowledge, highlight important remaining questions. We summarize physiological light human health well-being, including description processes underlying photic regulation circadian, neuroendocrine, neurobehavioral functions. review seminal work elucidating elements mediating potency these responses, specific attention factors critical interpreting those findings. parallel, endorse melanopic Equivalent Daylight Illuminance (Ev,melD65) as preferred measure quantify light. Ultimately, while future studies are necessary further facilitate laboratory domestic workplace settings, immediate better support is clear. Aiming integrative solutions biologically high during day low night perhaps most improvement made in order applications humans.

Язык: Английский

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Intermittent fasting in the prevention and treatment of cancer

CA A Cancer Journal for Clinicians, Год журнала: 2021, Номер 71(6), С. 527 - 546

Опубликована: Авг. 12, 2021

Abstract Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and clinical studies but may be difficult to sustain. As an alternative CR, there been growing interest intermittent fasting (IF) the scientific lay community as a result of promising study results, mainly experimental animal models. According survey by International Food Information Council Foundation, IF become most popular diet last year, patients with cancer are seeking advice from oncologists about its beneficial effects for prevention treatment. However, discussed this review, results rodents controversial suggest potential detrimental certain oncologic conditions. The on human incidence prognosis remain unknown because lack high‐quality randomized trials. Preliminary that prolonged some who have is safe potentially capable decreasing chemotherapy‐related toxicity tumor growth. additional trials needed elucidate risks benefits cancer, authors would not currently recommend undergoing active treatment partake outside context trial. considered adults cancer‐prevention through means weight management, whether itself affects cancer‐related metabolic molecular pathways remains unanswered.

Язык: Английский

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Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Journal of Pharmacokinetics and Pharmacodynamics, Год журнала: 2021, Номер 48(3), С. 321 - 338

Опубликована: Апрель 1, 2021

Язык: Английский

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Effects of Diet, Lifestyle, Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance

Nutrients, Год журнала: 2022, Номер 14(4), С. 823 - 823

Опубликована: Фев. 16, 2022

As years progress, we are found more often in a postprandial than postabsorptive state. Chrononutrition is an integral part of metabolism, pancreatic function, and hormone secretion. Eating most calories carbohydrates at lunch time early afternoon, avoiding late evening dinner, keeping consistent number daily meals relative times eating occasions seem to play pivotal role for glycemia insulin sensitivity. Sequence nutrients also significant role, as foods low density such vegetables, salads, or soups consumed first, followed by protein then starchy lead ameliorated glycemic responses. There several dietary schemes available, intermittent fasting regimes, which may improve Weight loss important the treatment resistance, it can be achieved many approaches, low-fat, low-carbohydrate, Mediterranean-style diets, etc. Lifestyle interventions with small weight (7-10%), 150 min weekly moderate intensity exercise behavioral therapy approach highly effective preventing treating type 2 diabetes. Similarly, decreasing improves significantly responses, but extent this reduction should individualized, patient-centered, monitored. Alternative ingredients, vinegar, yogurt, whey protein, peanuts tree nuts considered ameliorating hyperglycemia resistance. This review aims describe available evidence about effects diet, chrononutrition, alternative on

Язык: Английский

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