Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 1 - 36
Опубликована: Янв. 1, 2023
Язык: Английский
Theranostics, Год журнала: 2023, Номер 13(13), С. 4526 - 4558
Опубликована: Янв. 1, 2023
Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings traditional drug development models pose obstacles challenges to evaluation. Organ-on-a-chip (OoC) technology, which simulates human organs on a chip physiological environment functionality, with high fidelity reproduction organ-level physiology or pathophysiology, exhibits great promise for innovating pipeline. Meanwhile, advancement artificial intelligence (AI) provides more improvements design data processing OoCs. Here, we review current progress that made generate OoC platforms, how single multi-OoCs have used applications, including testing, disease modeling, personalized medicine. Moreover, discuss issues facing field, such as large reproducibility, point integration OoCs AI analysis automation, is benefit future Finally, look forward opportunities faced by coupling AI. In summary, advancements development, combinations AI, will eventually break state
Язык: Английский
Процитировано
60
Materials Today Advances, Год журнала: 2022, Номер 13, С. 100205 - 100205
Опубликована: Янв. 6, 2022
Microfluidic technology is a relatively new field among the various conventional bulk techniques employed for nanomaterial synthesis. Nanoparticles (NPs) produced using such methods generally have poor surface features, morphology, uncontrolled size and broad distributions. NPs especially used in biomedical sector require degree of control over their size, polydispersity to improve functionality. To synthesize NPs, microfluidic devices are ideal as parameters mixing rates, flow volumes, multiphase reactions can be controlled on micro/nanoscale. There several strategies challenges synthesis nanoparticles from organic inorganic materials platform. The faced during design implementation these devices, large scale production interaction with soft lithography materials, which overcome by use technique conjugation microfluidics, parallelisation processes search fabrication materials. On other hand, organ-on-chip (OOC) analytical cell cutures present mimic an organ along its physio-chemical properties study cell-nanoparticle interaction. issues construction cultures within device affected As biocompatible being printed into more appropriate designs, utilized contain said reduce risk error analysis NP properties, efficiency toxicity. This review aims discuss recent developments well toxicity efficacy evaluations technology.
Язык: Английский
Процитировано
71
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Июль 20, 2022
Abstract Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors last few decades, clinical translation rates are low owing to lack efficient models for evaluating and predicting responses. Microfluidics-based tumor-on-a-chip (TOC) provide a promising approach address these challenges. The integrated engineered platforms can recapitulate complex vivo tumor features at microscale level, such as microenvironment, three-dimensional tissue structure, dynamic culture conditions, thus improving correlation between results derived from preclinical trials anticancer nanomedicines. specific focus this review is describe recent advances TOCs evaluation nanomedicine, categorized into six sections based on drug process: circulation behavior after infusion, endothelial matrix barriers, uptake, therapeutic efficacy, safety, resistance. We also discuss current issues future directions an end-use perspective TOCs.
Язык: Английский
Процитировано
59
Ecotoxicology and Environmental Safety, Год журнала: 2022, Номер 235, С. 113429 - 113429
Опубликована: Март 21, 2022
Tremendous progress has been made in the field of toxicology leading to advance developmental toxicity assessment. Conventional animal models and vitro two-dimensional cannot accurately describe toxic effects predict actual vivo responses due obvious inter-species differences between humans animals, as well lack a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- induced pluripotent (iPSC)-derived three-dimensional organoids are ideal complex multicellular organotypic models, which indispensable recapitulating morphogenesis, cellular interactions, molecular processes early human organ development. Recently, have used for drug discovery, chemical safety This review discusses recent advances use organoid (i.e., brain, retinal, cardiac, liver, kidney, lung, intestinal models) teratogenicity assessment distinct tissues/organs following exposure pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, ambient air pollutants. Combining next-generation with innovative engineering technologies generates novel powerful tools assessment, rapid this is expected continue.
Язык: Английский
Процитировано
52
Biosensors, Год журнала: 2022, Номер 12(11), С. 1045 - 1045
Опубликована: Ноя. 18, 2022
Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes death worldwide. Due to unclear molecular mechanism complex vivo microenvironment tumors, it is challenging reveal nature develop effective therapeutics. Therefore, development new methods explore role heterogeneous TME individual patients’ drug response urgently needed critical for therapeutic management cancer. The organ-on-chip (OoC) platform, which integrates technology 3D cell culture, tissue engineering, microfluidics, emerging as a method simulate structures tumor functional characteristics. It overcomes failure traditional 2D/3D culture models preclinical animal completely replicate human tumors. As brand-new technology, OoC great significance realization personalized treatment drugs. This review discusses recent advances biology studies. focuses design principles devices associated applications modeling. challenges future this field are also summarized review. displays broad technique has reference value development.
Язык: Английский
Процитировано
42
Drug Discovery Today, Год журнала: 2023, Номер 28(4), С. 103496 - 103496
Опубликована: Янв. 20, 2023
Язык: Английский
Процитировано
28
Environment International, Год журнала: 2023, Номер 172, С. 107801 - 107801
Опубликована: Фев. 1, 2023
Atmospheric pollutants, including particulate matters, nanoparticles, bioaerosols, and some chemicals, have posed serious threats to the environment human's health. The lungs are responsible organs for providing interface between circulatory system external environment, where pollutant particles can deposit or penetrate into bloodstream circulation. Conventional studies decipher mechanism underlying air pollution human health quite limited, due lack of reliable models that reproduce in vivo features lung tissues after pollutants exposure. In past decade, advanced near-to-native chips, combining cell biology with bioengineered technology, present a new strategy atmospheric assessment narrow gap 2D culture animal models. this review, key artificial chips cutting-edge technologies chip manufacture introduced. recent progresses exposure summarized highlighted. We further discuss current challenges future opportunities development their potential utilities associated toxicity testing drug screening.
Язык: Английский
Процитировано
21
Journal of Biomedical Materials Research Part A, Год журнала: 2025, Номер 113(2)
Опубликована: Фев. 1, 2025
Organs-on-a-chip (OOC) are an emergent technology that bridge the gap between current in vitro and vivo models used to inform drug discovery investigate disease pathophysiology. These systems offer improved bio-relevance controlled complexity through integration of physical and/or chemical stimuli matched physiologically relevant conditions. Although significant advancements have been made toward recreating organ-specific physiology on chip, methods available study structure function cell microenvironment still limited. Established analysis approaches, including fluorescence microscopy, rely laborious offline workflows yield limited time-point data. As OOC field continues evolve, there is a unique opportunity engineer characterization into organ-chip devices. This review provides overview integrated sensing approaches address limitations enable real-time readout physiological parameters OOC.
Язык: Английский
Процитировано
1
Lab on a Chip, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
TapeTech is a flexible, adhesive-based microfluidic connectivity solution that streamlines fluidic integration with organ-on-a-chip devices by providing leak-proof sealing, mitigating pressure surges, and enabling rapid, cost-effective customization.
Язык: Английский
Процитировано
1
Small, Год журнала: 2022, Номер 18(39)
Опубликована: Июль 22, 2022
Abstract Despite recent advances in biofabrication, recapitulating complex architectures of cell‐laden vascular constructs remains challenging. To date, biofabricated models have not yet realized four fundamental attributes native vasculatures simultaneously: freestanding, branching, multilayered, and perfusable. In this work, a microfluidics‐enabled molding technique combined with coaxial bioprinting to fabricate anatomically relevant, consisting hydrogels is developed. By using 3D porous molds poly(ethylene glycol) diacrylate as casting templates that gradually release calcium ions crosslinking agent, perfusable geometries are fabricated. The bioinks can be tailored improve the compatibility specific cells tune mechanical modulus mimicking blood vessels. Crucially, integration relevant (such smooth muscle endothelial cells) multilayer biomimetic configuration highlighted. It also demonstrated fabricated freestanding vessels amenable for testing percutaneous coronary interventions (i.e., drug‐eluting balloons stents) under physiological states such stretching bending. Overall, versatile fabrication multifaceted possibilities generating benefit future research mechanistic understanding cardiovascular diseases development therapeutic introduced.
Язык: Английский
Процитировано
24