APOPTOSIS, Год журнала: 2024, Номер 29(11-12), С. 2161 - 2182
Опубликована: Окт. 11, 2024
Язык: Английский
Drug Resistance Updates, Год журнала: 2023, Номер 72, С. 101018 - 101018
Опубликована: Ноя. 11, 2023
Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role copper and triggered in pathogenesis cancers have attracted attentions. has garnered enormous interest cancer research communities because its great potential for therapy. Copper-based treatment exerts an inhibiting tumor growth may open door chemotherapy-insensitive tumors. In this review, we provide critical analysis on homeostasis dysregulation development progression cancers. Then core molecular mechanisms cuproptosis discussed, followed summarizing current understanding copper-based agents (copper chelators, ionophores, complexes-based dynamic therapy) treatment. Additionally, summarize emerging data ionophores to subdue chemotherapy resistance different types We also review small-molecule compounds nanoparticles (NPs) that kill cells inducing cuproptosis, which will shed new light anticancer drugs through future. Finally, important concepts pressing questions future should be focused were discussed. This article suggests targeting could novel antitumor therapy strategy overcome drug resistance.
Язык: Английский
Процитировано
94
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Янв. 13, 2024
Abstract Copper is an essential micronutrient that plays a pivotal role in numerous physiological processes virtually all cell types. Nevertheless, the dysregulation of copper homeostasis, whether towards excess or deficiency, can lead to pathological alterations, such as atherosclerosis. With advent concept copper-induced death, termed cuproptosis, researchers have increasingly focused on potential dyshomeostasis In this review, we provide broad overview cellular and systemic metabolism. We then summarize evidence linking atherosclerosis elucidate mechanisms underlying development terms both deficiency. Furthermore, discuss for its interactions with other modes highlight cuproptosis-related mitochondrial dysfunction Finally, explore therapeutic strategy targeting novel form aiming some insights management
Язык: Английский
Процитировано
26
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(4)
Опубликована: Апрель 25, 2024
Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.
Язык: Английский
Процитировано
23
Cancers, Год журнала: 2024, Номер 16(3), С. 512 - 512
Опубликована: Янв. 24, 2024
Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.
Язык: Английский
Процитировано
20
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Май 1, 2024
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.
Язык: Английский
Процитировано
19
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(6), С. 189013 - 189013
Опубликована: Окт. 31, 2023
Язык: Английский
Процитировано
27
Advanced Functional Materials, Год журнала: 2024, Номер 34(34)
Опубликована: Май 28, 2024
Abstract T lymphocytes play a central role in immunotherapy, utilizing physical interactions to actively inhibit the development of metastases. However, tumor immune privilege and heterogeneity pose challenges by protecting against attacks limiting cell infiltration into tumors, particularly invasive metastatic clusters. Here, penetrating magnetic particles (TUP) containing cascade‐responsive membrane‐mimetic copolymer (zwitterionic 2‐methacryloyloxyethyl phosphorylcholine‐co‐3‐hydroxypyridin‐4‐one, PH) cuproptosis molecules (elesclomol‐copper, EsCu) for programming is developed. The intravenously injected TUP accumulates at via charge conversion PH hyperthermia effects TUP. In clusters, ES Cu, triggered intracellular environments hyperthermia, are readily released. Cu simultaneously induce cancer cells stimulate responses. This process destroys self‐defense mechanisms exacerbates cytotoxicity. therapies facilitate release tumor‐associated antigens, including neoantigens damage‐associated molecular patterns. Following this, 3‐hydroxypyridin‐4‐one groups on act as antigen reservoirs, transporting autologous antigens dendritic cells, thereby inducing prolonged activation. acts an reservoir copper apoptosis‐mediated lung metastasis, promoting accumulation clusters effectively preventing progression tumors.
Язык: Английский
Процитировано
12
APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1330 - 1360
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
12
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116570 - 116570
Опубликована: Апрель 9, 2024
Copper is an essential trace element in the human body that extensively distributed throughout various tissues. The appropriate level of copper crucial to maintaining life activities body, and excess deficiency can lead diseases. levels are regulated by homeostasis, which maintains tissues cells controlling its absorption, transport, storage. Cuproptosis a distinct form cell death induced excessive accumulation intracellular copper. homeostasis cuproptosis has recently elicited increased attention realm health. emerged as promising avenue for cancer therapy. Studies concerning osteoarticular diseases have elucidated intricate interplay among cuproptosis, onset dysregulation cause abnormal bone cartilage metabolism, affecting related cells. This phenomenon assumes critical role pathophysiological processes underpinning diseases, with implications inflammatory immune responses. While early Cu-modulating agents shown promise clinical settings, additional research advancements warranted enhance their efficacy. In this review, we summarize effects potential mechanisms on cartilage, well regulatory roles pathological mechanism (e.g., osteosarcoma (OS), osteoarthritis (OA), rheumatoid arthritis (RA)). We also discuss clinical-application prospects copper-targeting strategy, may provide new ideas diagnosis treatment
Язык: Английский
Процитировано
11
Hypertension Research, Год журнала: 2024, Номер 47(5), С. 1440 - 1442
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
8