Metabolic reprogramming in cancer and senescence

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being aging population. Statistical data show that and mortality rates a clear upward with age. Although there is commonality between dysregulated nutrient sensing, which features aging, metabolic reprogramming tumor cells, specific regulatory relationship not clear. This manuscript intends to comprehensively analyze senescence reprogramming; as well reveal impact key factors leading cellular on tumorigenesis. In addition, this review summarizes current intervention strategies targeting sensing pathways, clinical cases treating tumors characteristics existing nanodelivery research strategies. Finally, it also suggests sensible dietary habits for those who wish combat aging. conclusion, attempts sort out link metabolism provide new ideas treatment.

Язык: Английский

Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation

Biochemical Journal, Год журнала: 2024, Номер 481(11), С. 683 - 715

Опубликована: Май 28, 2024

Human mitochondria possess a multi-copy circular genome, mitochondrial DNA (mtDNA), that is essential for cellular energy metabolism. The number of copies mtDNA per cell, and their integrity, are maintained by nuclear-encoded replication repair machineries. Aberrant breakage believed to cause deletions within mtDNA. genomic location breakpoint sequences these show similar patterns across various inherited acquired diseases, also observed during normal ageing, suggesting common mechanism deletion formation. However, an ongoing debate over the which replicates has made it difficult develop clear testable models how rearrangements arise propagate at molecular level. These may impair metabolism if present in high proportion can be seen primary either sporadic cases or caused autosomal variants maintenance genes. diseases have diverse genetic causes multiple modes inheritance, notoriously broad clinical heterogeneity with complex tissue specificities, further makes establishing genotype-phenotype relationships challenging. In this review, we aim cover our current understanding human genome replicated, mechanisms lead instability form large-scale rearrangements, rearranged mtDNAs subsequently accumulate cells, pathological consequences when occurs.

Язык: Английский

ENZYMATIC TOOLS FOR MITOCHONDRIAL GENOME MANIPULATION

Biochimie, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский