Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Compared
to
rodents,
inhibitory
interneurons
in
the
human
neocortex
exhibit
high
input
excitability
because
of
reduced
passive
ion
leakage
across
their
extracellular
membrane.
However,
regulation
intrinsic
by
voltage-gated
channels
activated
over
a
wide
range
membrane
potentials
remains
poorly
understood.
We
performed
whole-cell
patch-clamp
microelectrode
recordings
mouse
and
neocortical
slices
obtained
from
surgically
resected
non-pathological
brain
tissue
finding
that
Kir
control
electrical
resistance
parvalbumin
(Pvalb)
neurons
an
identical
manner
mouse.
Molecular
analyses
revealed
predominantly
Kir3.1
Kir3.2
Pvalb
both
species.
Using
synaptically
connected
neuron
pairs
computational
model,
we
demonstrated
physiological
activation
inhibits
during
postsynaptic
evoked
presynaptic
neurogliaform
cells.
The
similarity
Kir-mediated
inhibition
species
suggests
it
is
archetypal
property
neurons.
Язык: Английский
Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging
Brain Structure and Function,
Год журнала:
2025,
Номер
230(4)
Опубликована: Апрель 25, 2025
Язык: Английский
Elevated Astrocytic NFAT5 of the hippocampus increases epilepsy susceptibility in hypoxic‐ischemic mice
Epilepsia,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Hypoxic-ischemic
brain
damage
(HIBD)
is
a
leading
cause
of
neonatal
mortality,
resulting
in
injury
and
persistent
seizures
that
can
last
into
the
late
period
beyond.
Effective
treatments
interventions
for
infants
affected
by
hypoxia-ischemia
remain
lacking.
Clinical
investigations
have
indicated
an
elevation
nuclear
factor
activated
T
cells
5
(NFAT5)
whole
blood
from
umbilical
cords
severely
HIBD
with
epilepsy.
Experimental
research
has
demonstrated
NFAT5
ambivalent
effects
on
neuroprotection
neurologic
damage.
However,
mechanistic
role
remains
unclear.
This
investigation
aims
to
further
clarify
epilepsy
following
insult.
Язык: Английский
The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions
MedComm,
Год журнала:
2024,
Номер
5(11)
Опубликована: Окт. 23, 2024
Abstract
The
complement
system,
comprising
over
30
proteins,
is
integral
to
the
immune
and
coagulation
system
critical
for
vascular
homeostasis.
activation
of
systems
involves
an
organized
proteolytic
cascade,
overactivation
these
a
central
pathogenic
mechanism
in
several
diseases.
This
review
describes
role
illness,
particularly
sepsis.
complexities
sepsis
reveal
significant
knowledge
gaps
that
can
be
compared
profound
abyss,
highlighting
urgent
need
further
investigation
exploration.
It
well
recognized
inflammatory
network,
coagulation,
are
mechanisms
through
which
multiple
factors
contribute
increased
susceptibility
infection
may
result
disordered
response
during
septic
events
patients.
Given
overlapping
sepsis,
immunomodulatory
therapies
currently
under
development
beneficial
patients
with
who
have
concurrent
infections.
Herein,
we
present
recent
findings
regarding
molecular
relationships
between
pathways
advancement
propose
potential
intervention
targets
related
crosstalk
complement,
aiming
provide
more
valuable
treatment
Язык: Английский
Functional diversities within neurons and astrocytes in the adult rat auditory cortex revealed by single-nucleus RNA sequencing
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 25, 2024
The
mammalian
cerebral
cortex
is
composed
of
a
rich
diversity
cell
types.
Sensory
cortical
cells
are
organized
into
networks
that
rely
on
their
functional
to
ultimately
carry
out
variety
sophisticated
cognitive
functions
for
perception,
learning,
and
memory.
auditory
(AC)
has
been
most
extensively
studied
its
experience-dependent
effects,
including
perceptual
learning
associative
Here,
we
used
single-nucleus
RNA
sequencing
(snRNA-seq)
in
the
AC
adult
rat
investigate
breadth
transcriptionally
diverse
types
likely
support
role
functions.
A
unique
excitatory
inhibitory
neuron
subtypes
were
identified
harbor
transcriptional
profiles
genes
with
putative
relevance
adaptive
neuroplasticity
microcircuits.
In
addition,
report
first
time
astrocytes
may
represent
functionally
subtypes,
those
could
integrate
at
synapses.
Together,
these
results
pave
way
building
models
how
neurons
work
concert
fulfill
dynamic
Язык: Английский