Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 340 - 340

Опубликована: Март 6, 2025

Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) enhance the solubility and oral bioavailability of cannabidiol (CBD). Methods: According CBD pseudo-ternary phase diagrams different ingredients, an oil (medium-chain triglyceride, MCT), mixed surfactants (Labrasol, Tween 80), co-surfactant (Transcutol) were selected for SNEDDS. CBD-loaded SNEDDS formulations prepared characterized. The optimal was converted into powders via carrier adsorption spray drying techniques. Various evaluations including flowability, release, self-emulsifying capacity, X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), morphology, pharmacokinetic characteristics conducted. Subsequently, with fillers, disintegrants, lubricants added capsules accelerated stability testing. Results: investigations showed that two S-SNEDDS improved CBD’s in vitro good storage stability. data Sprague Dawley rats indicated single dose L-SNEDDS led quicker absorption higher Cmax compared oil-based controls (CBD-sesame (similar Epidiolex®) CBD-MCT), which is favorable application products. Conclusions: prospective strategy enhancing CBD, offers flexibility developing more formulations. Moreover, provides new concepts methods other poorly water-soluble drugs.

Язык: Английский

A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 712 - 712

Опубликована: Май 12, 2025

'Blood stasis' (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (). Similar concepts exist Korean ('Eohyul') and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down ('stasis') flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Язык: Английский

Transcriptomic analysis of wild Cannabis sativa: insights into tissue- and stage-specific expression and secondary metabolic regulation

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Май 26, 2025

Язык: Английский