Apoptosis, autophagy, ferroptosis, and pyroptosis in cisplatin-induced ototoxicity and protective agents
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 24, 2024
Cisplatin
is
widely
used
to
treat
various
solid
tumors.
However,
its
toxicity
normal
tissues
limits
clinical
application,
particularly
due
ototoxic
effects,
which
can
result
in
hearing
loss
patients
undergoing
chemotherapy.
While
significant
progress
has
been
made
preclinical
studies
elucidate
the
cellular
and
molecular
mechanisms
underlying
cisplatin-induced
ototoxicity
(CIO),
precise
remain
unclear.
Moreover,
optimal
protective
agent
for
preventing
or
mitigating
yet
be
identified.
This
review
summarizes
current
understanding
of
roles
apoptosis,
autophagy,
ferroptosis,
pyroptosis,
agents
ototoxicity.
A
deeper
these
cell
death
inner
ear,
along
with
agents,
could
facilitate
translation
into
therapeutics,
help
identify
new
therapeutic
targets,
provide
novel
strategies
cisplatin-based
cancer
treatment.
Язык: Английский
Studies on the mechanism of ototoxic action of cisplatin and the antagonistic effect of polyphenolic compounds
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 25, 2025
Cisplatin
is
a
highly
effective
broad-spectrum
anticancer
drug,
but
its
severe
ototoxicity
limits
clinical
application.
mainly
manifested
as
irreversible
hearing
loss,
and
mechanism
involves
various
pathways
such
DNA
damage,
oxidative
stress,
inflammatory
response,
mitochondrial
dysfunction,
ferroptosis.
In
recent
years,
natural
polyphenols
have
shown
great
potential
in
combating
cisplatin
due
to
their
powerful
antioxidant,
anti-inflammatory
anti-apoptotic
properties.A
variety
of
polyphenolic
compounds,
resveratrol,
curcumin,
quercetin,
etc.,
can
effectively
attenuate
the
damage
on
Corti
organs,
spiral
ganglion
neurons
vascular
striatum
by
scavenging
free
radicals,
inhibiting
release
factors,
regulating
expression
apoptosis-related
proteins.
addition,
some
enhance
anti-tumour
effect
while
antagonizing
ototoxicity.Although
show
good
application
prospects
prevention
treatment
ototoxicity,
there
are
still
problems
that
need
be
solved,
low
bioavailability
polyphenols,
action
has
not
yet
been
fully
elucidated,
optimal
dosing
regimen
determined,
whether
any
superimposed
combining
types
oral
exert
an
otoprotective
through
regulation
intestinal
flora
intestinal-auricular
axis.This
study
provides
new
insights
into
drug
candidates
for
CIO
summarising
cytotoxic
mechanisms
targeting
these
order
retard
progression
CIO.
It
ideas
approaches
next
step
focusing
development
low-toxic
control
ototoxicity.
Язык: Английский
Cisplatin-Induced Hearing Loss, Oxidative Stress, and Antioxidants as a Therapeutic Strategy—A State-of-the-Art Review
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1578 - 1578
Опубликована: Дек. 21, 2024
Cisplatin
is
an
established
component
of
treatment
protocols
for
various
solid
malignancies
but
carries
a
significant
potential
serious
adverse
effects.
Ototoxicity
from
cisplatin
important
dose-limiting
toxicity
that
manifests
as
bilateral,
progressive,
irreversible,
dose-dependent
sensorineural
hearing
loss,
ear
pain,
tinnitus,
and
vestibular
dysfunction.
Despite
the
recent
approval
sodium
thiosulphate
prevention
cisplatin-induced
loss
(CIHL)
in
pediatric
patients,
structured
programs
are
not
routinely
implemented
most
hospitals,
reducing
platinum-induced
ototoxicity
adults
remains
clinical
problem
without
options.
Cochlear
oxidative
stress
plays
fundamental
role
CIHL.
Here,
we
review
molecular
mechanisms
leading
to
CIHL
preclinical
studies
testing
antioxidants
guide
future
trials
assessing
efficacy
safety
candidate
antioxidant
compounds
this
setting.
Язык: Английский