Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1228 - 1228

Опубликована: Янв. 19, 2024

The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in body. Existing evidence suggests that nutrients can influence modulation gut microbiota. However, there still limited regarding effects vitamin mineral supplementation on through epigenetic modification. It plausible maintaining an adequate dietary intake D, iron, fibre, zinc magnesium may have beneficial effect alleviating inflammation body, reducing oxidative stress, improving condition various mechanisms. Moreover, epigenetics involves alterations phenotype cell without changing its fundamental DNA sequence. appears by lead to regulation. correlations between are interdependent. Therefore, primary objective this review identify complex relationships diet, microbiota, These interactions could play crucial role systemic health.

Язык: Английский

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Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence

Nutrition Research, Год журнала: 2023, Номер 120, С. 20 - 57

Опубликована: Сен. 28, 2023

Язык: Английский

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Beneficial microbiome and diet interplay in early-onset colorectal cancer

EMBO Molecular Medicine, Год журнала: 2024, Номер 17(1), С. 9 - 30

Опубликована: Дек. 9, 2024

Язык: Английский

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Resilience to Global Health Challenges Through Nutritional Gut Microbiome Modulation

Nutrients, Год журнала: 2025, Номер 17(3), С. 396 - 396

Опубликована: Янв. 22, 2025

As the world faces an escalating challenge of non-communicable diseases (NCDs), with phenotypes ranging from allergic chronic immuno-inflammatory to neuropsychiatric disorders, it becomes evident that their seeds are sown during early stages life. Furthermore, within only a few decades, human obesity has reached epidemic proportions and now represents most serious public health our time. Recent demonstrations growing number these conditions linked aberrant gut microbiota composition function have evoked active scientific interest in host-microbe crosstalk, characterizing modulating at-risk circumstances. These efforts appear particularly justified critical period developmental plasticity when child’s immune, metabolic, microbiological constitutions lend themselves long-term adjustment. Pregnancy infancy epitomize ideal juncture for preventive measures aiming reduce risk NCDs; by promoting pregnant lactating women today, next generation(s) may be successfully improved. The perfect tools this initiative derive earliest massive source environmental exposures, namely microbiome nutrition, due fundamental interactions host immune metabolic maturation.

Язык: Английский

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Dietary index for gut microbiota, a novel protective factor for the prevalence of chronic kidney diseases in the adults: insight from NHANES 2007–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 19, 2025

Introduction This study explore the association between dietary index for gut microbiota (DI-GM) and prevalence of chronic kidney disease (CKD). Method A cross-sectional participants aged ≥20 years using data drawn from NHANES (2007–2018). DI-GM is comprised 14 components (10 beneficial 4 unfavorable). CKD diagnosis based on urine albumin-to-creatinine ratio (uACR) estimated glomerular filtration rate (eGFR). Logistic regression models were employed to evaluate relationship while controlling various covariates. Additionally, a spline smooth analysis was performed. Subgroup interaction analyses conducted investigate whether any factors modified this relationship. Results total 28,843 eligible study, whom 5,461 diagnosed with CKD, 23,382 not. Patients exhibited significantly lower scores compared healthy individuals. negative observed across all models, being more pronounced in individuals greater than 5 those ≤3. Beneficial components, such as fiber, whole grains, coffee, identified protective factors. Moreover, sex make an effect relationship, stronger effects noted women. Conclusion Higher correlate reduced prevalence, appears be women men. These findings suggest that enhancing health through diet may serve viable strategy prevention management particular attention sex-based differences prevention.

Язык: Английский

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Fecal Microbiota and Metabolites Predict Metabolic Health Features Across Various Dietary Patterns in Adults

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Consuming healthful dietary patterns reduces the risk of developing metabolic diseases and nourishes intestinal microbiota. Thus, investigating microbial underpinnings influences on health is clinical interest. To determine unique contributions fecal taxa metabolites in predicting markers adults across various patterns. Dietary, metabolic, microbiota metabolome data from 118 (25-45y) were used for these cross-sectional analyses. The Diet History Questionnaire II assessed adherence to Dietary Approaches Stop Hypertension (DASH), Mediterranean diet, Mediterranean-DASH Intervention Neurocognitive Delay (MIND), Healthy Eating Index-2020 (HEI-2020). Metabolic features included waist circumference, blood pressure, circulating triglyceride (TG), high-density lipoprotein cholesterol (HDL), glucose concentrations. Microbiota composition was via 16S amplicon sequencing volatile fatty acid bile concentrations measured by targeted metabolomics. ANCOM-BC2 correlation analyses screen independently associated with markers. Then, hierarchical linear regression models evaluate select beyond HEI-2020 positively richness (p = 0.02). Beta diversity varied all < 0.05). DASH diet scores, [Eubacterium] xylanophilum abundance, deoxycholic (DCA) concentration explained most variance systolic (R2 0.32) diastolic 0.26) pressure compared other features. TG best predicted MIND [E]. eligens isobutyrate 0.24). Integrating alongside indices improved marker prediction. These results point a potential role underpinning physiological responses highlight biomarkers health.

Язык: Английский

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The incorporation of red meat in higher-HEI diets supports brain-health critical nutritional adequacy, and gut microbial diversity

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

We evaluated whether red meat could be integrated into a high Healthy Eating Index (HEI) diet to improve brain health-critical nutrient adequacy without compromising quality, mental health, or gut microbiota. Using data from 3,643 adults in the American Gut Project, participants were stratified four groups: high-HEI (≥ 80) with (HH-R), (HH-NR), low-HEI (< (LH-R), and (LH-NR). Both groups maintained healthy BMI values regardless of intake. HH-R had higher protein intake lower carbohydrate intake, saturated fat levels within recommended limits. Brain micronutrient adequacies (selenium, vitamin B12, zinc, calcium, D3, choline) significantly (p < 0.001). Higher HEI scores, irrespective consumption, associated reduced odds depression (logOR= -2.22), PTSD -3.80), bipolar disorder -5.90). microbiota diversity richness highest HH-R, increased Bacteroides caccae (p_adj = 0.003) Clostridium hathewayi 0.001), while HH-NR showed Bifidobacterium adolescentis eggerthii Therefore, these findings suggest that inclusion lean improves health-supporting adverse effects on health microbial diversity.

Язык: Английский

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Early-life and concurrent predictors of the healthy adolescent microbiome in a cohort study

Genome Medicine, Год журнала: 2025, Номер 17(1)

Опубликована: Май 8, 2025

The microbiome of adolescents is poorly understood, as are factors influencing its composition. We aimed to describe the healthy adolescent and identify early-life concurrent predictors performed metagenomic sequencing 247 fecal specimens from 167 aged 11-14 years participating in Health Outcomes Measures Environment (HOME) Study, a longitudinal pregnancy birth cohort (Cincinnati, OH). described common features gut applied self-organizing maps (SOMs)-a machine-learning approach-to distinct microbial profiles (n = 4). Using prospectively collected data on sociodemographic characteristics, lifestyle, diet, sexual maturation, we identified associated with diversity phylum relative abundance linear regression models composition Kruskal-Wallis Fisher's exact tests. found that household income other were consistent microbiome, higher lower differential abundances Firmicutes (increased) Actinobacteria (decreased). Sexual chronological age, was related females differences compositional both males females. Our study suggests adolescence unique window for it may be shaped by exposures, highlighting potential future epidemiologic research.

Язык: Английский

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Dietary convergence induces individual responses in faecal microbiome composition

eGastroenterology, Год журнала: 2025, Номер 3(2), С. e100161 - e100161

Опубликована: Апрель 1, 2025

Background Dietary variation has been identified as a key contributor to microbiome diversification. However, assessing its true impact in cross-sectional setting is complicated by biological confounders and methodological hurdles. We aimed estimate the of reduction dietary (dietary convergence) on faecal microbiota composition among individuals consuming Western-type diet. Methods 18 healthy volunteers recruited region Flanders (Belgium) were followed up for 21 days. Participants allowed consume their habitual diet during baseline follow-up period (7 8 days, respectively), intersected 6-day intervention which options restricted oat flakes, whole milk still water. Faecal samples collected daily basis. Quantitative profiles constructed, combining 16S rRNA gene amplicon sequencing with flow cytometry cell counting. Blood taken at beginning end each study week. Results While did not affect transit time (as assessed through analysis stool moisture), consumption resulted an increased prevalence Bacteroides 2 community type. Microbial load Faecalibacterium abundance decreased markedly. Despite restrictions, no convergence microbial communities (reduction interindividual intraindividual variation) was observed. The effect size (ES) genus-level differentiation estimated 3.4%, but substantial observed (1.67%–16.42%). Conclusion Western population significant limited ES, notable individual exceptions. does invariably translate into communities.

Язык: Английский

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Association of leisure time physical activity with gut microbiota composition in early adulthood

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Июнь 4, 2025

Abstract Physical activity is associated with compositional changes in gut microbiota. Studies applying data from general populations exhibiting varying physical levels are scarce. This study investigated the associations between leisure time and microbiota composition a population of young adults. Faecal samples were analyzed 16 S rRNA sequencing assessed N = 302 (176 females, 126 males) 26-year-old individuals European descent. Leisure was using self-administrated questionnaire expressed as metabolic equivalent (MET) h/wk. Participants defined inactive ( 83) active 219) based on estimation to meet guidelines. Diet food diaries. First, then models further adjusted for diet 280). While diversity similar, community differed participants. The association diluted after adjustment diet. Moreover, genera, e.g., Lactobacillus , Veillonella Prevotella more abundant compared After diet, these associations, except Barnesiella no longer detected, but other genera found. In conclusion, adults an increase abundance considered beneficial overall health. partly confounded by

Язык: Английский

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