A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

Frontiers in Toxicology, Год журнала: 2022, Номер 4

Опубликована: Апрель 11, 2022

Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that chemically stable, resistant to degradation, persistent in terrestrial aquatic environments. Widespread use PFAS industrial processing manufacturing over the last 70 years has led global contamination built natural The brain is lipid rich highly vascularized organ composed long-lived neurons glial cells especially vulnerable impacts lipophilic toxicants. Generally, partition protein-rich tissues body, primarily liver blood, but also detected brains humans, wildlife, laboratory animals. Here we review factors impacting absorption, distribution, accumulation brain, currently available evidence for neurotoxic defined by disruption neurochemical, neurophysiological, behavioral endpoints. Emphasis placed on potential exposures during critical periods development sensitive populations, may exacerbate neurotoxicity PFAS. While limitations inconsistencies across studies exist, body suggests neurobehavioral long-chain more pronounced than resulting from exposure adulthood. There paucity experimental evaluating molecular mechanisms short-chain PFAS, even greater data gaps analysis outside perfluoroalkyl acids. Whereas most were focused acute subchronic high dose single congener, realistic humans wildlife mixtures relatively chronic low nature. Our evaluation human epidemiological, experimental, indicates heightened acids after environmental exposure, comparison studies. These findings highlight need additional neurodevelopmental environmentally relevant concentrations complex

Язык: Английский

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Exposure to phthalates and female reproductive health: A literature review

Reproductive Toxicology, Год журнала: 2022, Номер 109, С. 61 - 79

Опубликована: Март 3, 2022

Язык: Английский

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Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes

Chemosphere, Год журнала: 2022, Номер 295, С. 133873 - 133873

Опубликована: Фев. 7, 2022

Язык: Английский

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Environmental impacts, exposure pathways, and health effects of PFOA and PFOS

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 267, С. 115663 - 115663

Опубликована: Ноя. 1, 2023

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that have been widely utilized in various industries since the 1940s, now emerged as environmental contaminants. In recent years, perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS) restricted replaced with several alternatives. The high persistence, bioaccumulation, toxicity of these contributed to their emergence contaminants, aspects behavior remain largely unknown require further investigation. trace level PFAS makes development a monitoring database challenging. Additionally, potential health issues associated not yet fully understood due ongoing research inadequate evidence (experimental epidemiological studies), especially regard combined effects exposure mixtures human risks from drinking water consumption. This in-depth review offers unprecedented insights into pathways toxicological impacts PFAS, addressing critical knowledge gaps behaviors implications. It presents comprehensive NABC—Needs, Approach, Benefits, Challenges—analysis guide future strategies for sustainable management pervasive

Язык: Английский

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Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Май 30, 2023

Abstract Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- polyfluoroalkyl substances (PFAS) has been reported reduce length gestation, but the underlying mechanisms are unknown. In present study, we characterized molecular signatures prenatal PFAS exposure gestational age at outcomes in newborn dried blood spot metabolome among 267 African American dyads Atlanta, Georgia between 2016 2020. Pregnant people with higher serum perfluorooctanoic acid perfluorohexane sulfonic concentrations had increased odds an After false discovery rate correction, effect on reduced gestation was associated 8 metabolomic pathways 52 metabolites spots, which suggested perturbed tissue neogenesis, neuroendocrine function, redox homeostasis. These explain how gives rise leading cause infant death United States.

Язык: Английский

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A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)

Archives of Toxicology, Год журнала: 2023, Номер 97(5), С. 1195 - 1245

Опубликована: Март 22, 2023

Язык: Английский

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The adverse role of endocrine disrupting chemicals in the reproductive system

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 17, 2024

Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation changes in lifestyle, the occurrence of these is closely connected exposure harmful substances environment. Endocrine disrupting chemicals (EDCs), characterized hormone-like effects, have a wide range influences on reproductive system. EDCs are ubiquitous natural environment present industrial everyday products. Currently, thousands been reported exhibit endocrine this number likely increase as testing for potential has not consistently required, obtaining data limited, partly due long latency many diseases. The ability avoid EDCs, especially those artificially synthesized origin, increasingly challenging. While can be divided into persistent non-persistent depending their degree degradation, recent uptick research studies area, we chosen focus pertaining detrimental effects health several that widely encountered daily life over past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, so on. By focusing impact hypothalamic-pituitary-gonadal (HPG) axis, which leads development diseases, review aims provide new insights molecular mechanisms EDCs’ damage encourage further in-depth clarify potentially EDC through various other mechanisms. Ultimately, it offers scientific basis enhance risk management, an endeavor significant societal importance safeguarding health.

Язык: Английский

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Trends in Serum Per- and Polyfluoroalkyl Substance (PFAS) Concentrations in Teenagers and Adults, 1999–2018 NHANES

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(21), С. 6984 - 6984

Опубликована: Окт. 27, 2023

Some types of per- and poly-fluoroalkyl substances (PFAS) have been banned over the last two decades, but millions Americans continue to exposure compounds through drinking water consumer products. Therefore, understanding changes in serum PFAS concentrations after their limited use is necessary protect public health. In this study, we evaluated trends (PFOS, PFOA, PFHxS, PFDA, PFNA) determine distribution among United States general population. We analyzed measured from random subsamples National Health Nutrition Examination Survey (NHANES) participants. The study results demonstrated that demographic factors such as race/ethnicity, age, sex may influence levels time. Adults, males, Asians, Non-Hispanic Blacks, Whites had high risks selected PFAS. Overall, declined continuously studied population 1999 2018. Among population, PFOS PFDA were most least prevalent blood serum, respectively. Serum PFHxS showed upward at one racial/ethnic group 2016, which underscores need for continuous biomonitoring humans environment.

Язык: Английский

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Associations of prenatal PFAS exposure and early childhood neurodevelopment: Evidence from the Shanghai Maternal-Child Pairs Cohort

Environment International, Год журнала: 2023, Номер 173, С. 107850 - 107850

Опубликована: Фев. 25, 2023

Epidemiological data on the effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) infant neurodevelopment trajectories are far from being sufficiently addressed. In this study, 1285 mother-child pairs were recruited during 2016-2017. A high-performance liquid chromatography-triple quadrupole mass spectrometer was used to measure 16 PFAS levels in cord serum. Ages Stages Questionnaires examine children's at 2, 6, 12, 24 months age. Group-based trajectory models applied derive neurodevelopmental trajectories. Children with relatively low scores 2 classified into a low-score group as risk each domain. Multiple linear regression, logistic quantile-based g-computation performed assess associations single or mixture exposures Perfluorooctane sulphonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic (PFHxS), 6:2 chlorinated polyfluorooctane ether sulfonate (6:2Cl-PFESA) detected over 90 % samples. PFOA had highest concentration (median: 4.61 μg/L). Each ln-unit (μg/L) increase (e.g., PFOA, PFOS, PFHxS, 6:2Cl-PFESA) associated poor communication domain 6 months, effect size ranging -0.69 -0.44. PFOS (OR: 1.14, (1.03, 1.26), PFDA (OR:1.08, (1.02, 1.15)), PFHxS (OR:1.31, (1.12, 1.56)), 6:2Cl-PFESA (1.00, 1.16)) an increased early childhood domain's trajectory. quartile increment 1.60 (-2.76, -0.45) decrease 6-month-old infants, mainly attributed PFOS. 1.23-fold 1.46) domain, conclusion, their mixtures might adversely affect neurodevelopment. The gender-specific existed above associations.

Язык: Английский

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Determinants of maternal and neonatal PFAS concentrations: a review

Environmental Health, Год журнала: 2023, Номер 22(1)

Опубликована: Май 10, 2023

Per- and polyfluoroalkyl substances (PFAS) are used for their properties such as stain water resistance. The have been associated with adverse health outcomes in both pregnant mothers infants, including pre-eclampsia low birthweight. A growing body of research suggests that PFAS transferred from mother to fetus through the placenta, leading utero exposure. systematic review was performed using PubMed database search studies evaluating determinants concentrations blood matrices neonates shortly after birth. Studies were included this if an observational study design utilized, exposure at least one analyte measured, measured maternal or neonatal matrices, determinant assessed, results beta estimates provided. We identified 35 inclusion evaluated relationships among factors collected these studies. Parity, breastfeeding history, race country origin, household income had strongest most consistent evidence support roles certain mothers. Reported findings on smoking status, alcohol consumption, pre-pregnancy mass index (BMI) suggest not important neonates. Further into informative consumer product use, detailed dietary information, consumed sources potential is needed. Research critical estimate past exposure, build improved models, further our understanding dose-response relationships, which can influence epidemiological risk assessment evaluations. Given exposed PFAS, it identify understand better implement public interventions populations.

Язык: Английский

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