Molecules,
Год журнала:
2023,
Номер
28(17), С. 6344 - 6344
Опубликована: Авг. 30, 2023
Cadmium
(Cd),
a
harmful
heavy
metal
that
has
no
biological
purpose,
can
harm
healthy
fetal
and
child
development.
Epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
in
tea,
been
shown
to
increase
cell
viability
under
Cd
exposure
ameliorate
Cd-induced
kidney
injury
adult
male
rats.
Using
Caenorhabditis
elegans
(C.
elegans)
model,
we
demonstrated
EGCG
mitigated
body
size
developmental
toxicity
through
mechanism
did
not
involve
chelation
with
was
associated
accumulation
efflux.
Our
research
indicated
beneficial
effects
of
on
were
mitigation
endoplasmic
reticulum
stress.
Furthermore,
our
observations
indicate
reduced
C.
via
PEK-1/eIF-2α/ATF-4
pathway.
results
provide
important
evidence
for
potential
benefits
consuming
tea
as
detoxification
agent.
PLoS ONE,
Год журнала:
2024,
Номер
19(3), С. e0292179 - e0292179
Опубликована: Март 7, 2024
Epigenetic
changes
in
sexually
reproducing
animals
may
be
transmitted
usually
only
through
a
few
generations.
Here
we
discovered
case
where
epigenetic
change
lasts
40
This
phenomenon
occurs
the
short
antennae
(
sa
)
mutation
of
flour
moth
Ephestia
kuehniella
).
We
demonstrate
that
is
probably
determined
by
small
RNA
(e.g.,
piRNA,
miRNA,
tsRNA)
and
this
way
to
subsequent
generations
male
female
gametes.
The
observed
cancels
creates
wild
phenotype
(a
appears
have
no
mutation).
It
persists
for
many
(40
recorded).
transgenerational
effect
(suppression
homozygous
antennae)
induced
during
ontogenetic
development,
such
as
increased
temperature
on
pupae
food,
different
salts
or
injection
from
sperm
already
affected
individuals
into
eggs.
occasionally
disappear
some
and/or
progeny
pair
generation
chain
which
transfers.
consider
survival
over
has
adaptive
consequences.
mainly
response
environmental
offspring
via
RNA.
In
study,
test
an
interesting
with
unexpected
length
after
what
its
cause.
Such
transfer
greater
evolutionary
significance
than
previously
thought.
Based
analogies,
also
discuss
connection
SIR2
gene.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 10996 - 10996
Опубликована: Окт. 12, 2024
Maternal
cadmium
exposure
during
pregnancy
has
been
demonstrated
to
have
detrimental
effects
on
offspring
development.
However,
the
impact
of
maternal
oocytes
remains
largely
unknown,
and
underlying
mechanisms
are
not
fully
understood.
In
this
study,
we
found
that
resulted
in
selective
alteration
epigenetic
modifications
mouse
offspring,
including
a
decrease
H3K4me2
H4K12ac,
as
well
an
increase
DNA
methylation
Molecules,
Год журнала:
2023,
Номер
28(17), С. 6344 - 6344
Опубликована: Авг. 30, 2023
Cadmium
(Cd),
a
harmful
heavy
metal
that
has
no
biological
purpose,
can
harm
healthy
fetal
and
child
development.
Epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
in
tea,
been
shown
to
increase
cell
viability
under
Cd
exposure
ameliorate
Cd-induced
kidney
injury
adult
male
rats.
Using
Caenorhabditis
elegans
(C.
elegans)
model,
we
demonstrated
EGCG
mitigated
body
size
developmental
toxicity
through
mechanism
did
not
involve
chelation
with
was
associated
accumulation
efflux.
Our
research
indicated
beneficial
effects
of
on
were
mitigation
endoplasmic
reticulum
stress.
Furthermore,
our
observations
indicate
reduced
C.
via
PEK-1/eIF-2α/ATF-4
pathway.
results
provide
important
evidence
for
potential
benefits
consuming
tea
as
detoxification
agent.
