International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12646 - 12646
Опубликована: Ноя. 25, 2024
The
widespread
use
of
polyvinyl
chloride
(PVC)
and
its
entry
into
humans
livestock
is
serious
concern.
In
our
study,
we
investigated
the
impact
PVC
treatments
on
physiological,
pathological,
hormonal,
microbiota
changes
in
female
rabbits.
Trend-like
alterations
weight
were
observed
spleen,
liver,
kidney
both
low
(P1)
high
dose
(P2)
treatment
groups.
Histopathological
examination
revealed
exfoliation
intestinal
mucosa
treated
groups
compared
to
control,
microplastic
particles
penetrated
embedded
spleen.
Furthermore,
P1
P2
showed
increased
17-beta-estradiol
(E2)
hormone
levels,
indicating
early
sexual
maturation.
Moreover,
elevated
tumor
necrosis
factor
alpha
(TNF-α)
levels
suggest
inflammatory
reactions
associated
with
treatment.
Genus-level
analyses
gut
group
several
genera
or
decreased
abundance.
conclusion,
significant
trend-like
correlations
demonstrated
between
content
feed
parameters.
To
knowledge,
this
first
study
investigate
broad-spectrum
effects
exposure
These
results
highlight
potential
health
risks
exposure,
warranting
further
investigations
animals
humans.
Plant Physiology and Biochemistry,
Год журнала:
2024,
Номер
207, С. 108403 - 108403
Опубликована: Янв. 27, 2024
The
effects
of
polyethylene
terephthalate
micro-nanoplastics
(PET-MNPs)
were
tested
on
the
model
freshwater
species
Spirodela
polyrhiza
(L.)
Schleid.,
with
focus
possible
particle-induced
epigenetic
(i.e.
alteration
DNA
methylation
status).
MNPs
(size
∼
200-300
nm)
produced
as
water
dispersions
from
PET
bottles
through
repeated
cycles
homogenization
and
used
to
prepare
N-medium
at
two
environmentally
relevant
concentrations
(∼0.05
g
L
Journal of Heredity,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 13, 2024
Microplastics
have
evolutionary
and
ecological
impacts
across
species,
affecting
organisms'
development,
reproduction,
behavior
along
with
contributing
to
genotoxicity
stress.
As
plastic
pollution
is
increasing
ubiquitous,
gaining
a
better
understanding
of
organismal
responses
microplastics
necessary.
Epigenetic
processes
such
as
DNA
methylation
are
heritable
forms
molecular
regulation
influenced
by
environmental
conditions.
Therefore,
determining
epigenetic
will
reveal
potential
chronic
consequences
this
pollutant.
We
performed
an
experiment
two
generations
fathead
minnows
(Pimephales
promelas)
elucidate
transgenerational
effects
microplastic
exposure.
exposed
the
first
generation
fish
four
different
treatments
microplastics:
concentrations
each
pre-consumer
polyethylene
(PE)
PE
collected
from
Lake
Ontario.
then
raised
filial
no
used
enzymatic
sequencing
on
adult
liver
tissue
homogenized
larvae
evaluate
differences
among
treatments,
sexes,
generations.
Our
findings
show
origin
had
larger
effect
in
female
whereas
concentration
was
stronger
males.
also
observed
effects,
highlighting
mechanism
which
parents
can
pass
exposure
their
offspring.
Many
genes
found
within
differentially
methylated
regions
our
analyses
known
interact
estrogenic
chemicals
associated
related
metabolism.
This
study
highlights
persistent
potentially
serious
gene
freshwater
systems.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13619 - 13619
Опубликована: Сен. 3, 2023
There
have
been
concerns
about
the
potential
health
risks
posed
by
microplastics
(MP).
The
detection
of
MP
in
a
variety
food
products
revealed
that
humans
are
ingesting
MP.
Nevertheless,
there
is
paucity
data
their
impacts,
as
well
uptake,
on
intestinal
barrier
integrity.
This
study
examined
toxic
effects
oral
administration
two
doses
polyethylene
(PE-MP)
(3.75
or
15
mg/kg/day
for
5
weeks;
mean
particle
size:
4.0-6.0
µm)
integrity
rats.
Moreover,
effect
melatonin
treatment
with
exposure
was
also
assessed.
PE-MP
histopathological
changes,
Alcian
blue
staining,
Muc2
mRNA,
proinflammatory
cytokines
(IL-1β
and
TNF-α),
cleaved
caspase-3,
tight
junction
proteins
(claudin-1,
myosin
light-chain
kinase
(MLCK),
occludin,
zonula
occludens-1
(ZO-1))
were
Oral
resulted
apparent
jejunal
alterations;
significantly
decreased
mucin
secretion,
ZO-1,
claudin-1
expression;
upregulated
MLCK
IL-1β
concentration,
caspase-3
expression.
Melatonin
reversed
these
altered
parameters
improved
PE-MP-induced
ultrastructure
changes.
highlighted
PE-MP's
protective
melatonin.
