Difenoconazole
(DFZ)
is
a
typical
triazole
fungicide,
which
widely
used
in
agricultural
production,
but
residues
of
DFZ
the
environment
pose
serious
hazard
to
non-target
organisms.
Ferulic
acid
(FA)
phenolic
compound
with
pharmacological
activities
such
as
antioxidant
and
anti-inflammatory.
The
purpose
this
study
was
investigate
hepatic
damage
carp
mechanism
action
FA
alleviating
tissue
induced
by
exposure
carp.
It
discovered
that
improved
liver
carp's
capability
decreased
accumulation
ROS
tissue.
Meanwhile,
controlled
transcriptional
levels
inflammation-related
factors
prevented
inflammatory
response
brought
on
NF-κB
signaling
pathway.
Additionally,
TUNEL
results
demonstrated
beginning
apoptosis,
whereas
dietary
supplementation
reduced
protein
expression
Bax
Cytochrome
C
(Cyt
c)
apoptosis-related
genes,
increased
Bcl-2.
In
conclusion,
protects
against
injury
modulating
oxidative
damage,
inflammation
apoptosis.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 21, 2024
Abstract
Abamectin
toxicity
in
humans
is
an
uncommon
but
potentially
fatal
cause
of
pesticide
poisoning.
In
this
case
report,
a
14-year-old
boy
drank
almost
50
ml
1.8%
spray.
Based
on
the
history
given
by
his
brother,
patient
initially
got
irritable
with
strong
smell
poison
and
froth
coming
out
mouth.
At
time
presentation
Emergency
Department
(ED),
was
vomiting
then
gradually
developed
altered
mental
status
hypotension,
tachycardia,
hyperaemic
conjunctiva,
dermal
erythema.
He
treated
symptomatically
antihistamines,
steroids,
fluids,
vaso-active
agents.
His
vitals
stabilised
within
24
hours
intake
after
3
days
hospital
stay
including
2
observation,
he
discharged
good
condition
complete
recovery.
Although
abamectin
intoxication
has
higher
threshold
for
humans,
there
are
still
increasing
number
cases
it.
Consumption
substantial
amounts
can
prove
to
be
fatal.
There
lack
literature
research
its
mechanism
toxicity,
pathophysiology,
or
management
guidelines.
Yet
like
managed
based
supportive
principles
recovery
no
sequelae.
Difenoconazole
(DFZ)
is
a
typical
triazole
fungicide,
which
widely
used
in
agricultural
production,
but
residues
of
DFZ
the
environment
pose
serious
hazard
to
non-target
organisms.
Ferulic
acid
(FA)
phenolic
compound
with
pharmacological
activities
such
as
antioxidant
and
anti-inflammatory.
The
purpose
this
study
was
investigate
hepatic
damage
carp
mechanism
action
FA
alleviating
tissue
induced
by
exposure
carp.
It
discovered
that
improved
liver
carp's
capability
decreased
accumulation
ROS
tissue.
Meanwhile,
controlled
transcriptional
levels
inflammation-related
factors
prevented
inflammatory
response
brought
on
NF-κB
signaling
pathway.
Additionally,
TUNEL
results
demonstrated
beginning
apoptosis,
whereas
dietary
supplementation
reduced
protein
expression
Bax
Cytochrome
C
(Cyt
c)
apoptosis-related
genes,
increased
Bcl-2.
In
conclusion,
protects
against
injury
modulating
oxidative
damage,
inflammation
apoptosis.
