Progress in Natural Science Materials International, Год журнала: 2024, Номер 34(5), С. 1009 - 1020
Опубликована: Авг. 10, 2024
Язык: Английский
Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 486 - 507
Опубликована: Янв. 14, 2024
Diabetes as a fastest growing diseases worldwide is characterized by elevated blood glucose levels. There's an enormous financial burden associated with this endocrine disorder, unequal access to health care between developed and developing countries. PI3Ks (phosphoinositide 3-kinases) have been demonstrated be crucial for homeostasis, malfunctioning of these molecules can contribute increase in serum levels, the main pathophysiological feature diabetes. Additionally, recent evidence suggests that miRNAs lncRNAs are reciprocally interacting signaling pathway. It therefore evident abnormal regulation miRNAs/lncRNAs lncRNAs/miRNAs/PI3K/AKT axis related clinicopathological characteristics plays role biological processes. has attempted review describe interaction PI3K/AKT pathway various their importance DM biology. We also presented clinical applications PI3K/AKT-related ncRNAs/herbal medicine patients DM.
Язык: Английский
Процитировано
12
Elsevier eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Май 1, 2024
Primary testicular lymphoma (PTL) is a rare predominantly occurring in the elderly male population. It characterized by limited response to treatment and heightened tendency towards relapse. Histologically, approximately 90% of PTL cases are classified as diffuse large B-cell lymphomas (DLBCL). Genetic features were delineated scope within several independent studies. Some articles which analyzed genetic characterization DLBCL have incorporated samples, but these been constrained small sample sizes. In addition, there an absence molecular typing studies PTL. This report summarizes common mutational features, copy number variations (CNVs) patients, based on whole-exome sequencing (WES) conducted cohort 25 patients. Among them, HLA, CDKN2A MYD88 had high mutation frequency. we found two core characteristics including genes linked genomic instability (TP53 CDKN2A) immune-related (HLA, MYD88, CD79B). We performed patients into C1 subtype with TP53 mutations C2 HLA mutations. Notably, gene predicted poor outcome most types lymphomas. However, subtype, dominated mutations, better prognosis compared exhibited worse prognosis, aligning our finding that mechanism immune escape was primarily deletions rather than PD-L1/PD-L2 alterations, contrast other DLBCLs. Moreover, calculated tumor burden (TMB) identified TMB can predict recurrence rate Our study underscores significance characteristics, plays crucial role prognostication guiding therapeutic strategies for
Язык: Английский
Процитировано
3
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Май 2, 2024
Abstract Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides. Despite their inability to code proteins, multiple studies have identified important role in human cancer through different mechanisms. LncRNA lysyl oxidase like 1 antisense RNA (LOXL1-AS1), a newly discovered lncRNA located on chromosome 15q24.1, has recently been shown be involved the occurrence and progression of various malignancies, such as colorectal cancer, gastric hepatocellular carcinoma, prostate non-small cell lung ovarian cervical breast glioma, thymic pancreatic carcinoma. LOXL1-AS1 acts competitive endogenous (ceRNA) via sponging miRNAs, including miR-374b-5p, miR-21, miR-423-5p, miR-589-5p, miR-28-5p, miR-324-3p, miR-708-5p, miR-143-3p, miR-18b-5p, miR-761, miR-525-5p, miR-541-3p, miR-let-7a-5p, miR-3128, miR-3614-5p, miR-377-3p miR-1224-5p promote tumor proliferation, invasion, migration, apoptosis, cycle, epithelial–mesenchymal transformation (EMT). In addition, is regulation P13K/AKT MAPK signaling pathways. This article reviews current understanding biological function clinical significance cancers. These findings suggest may both reliable biomarker potential therapeutic target for
Язык: Английский
Процитировано
3
Critical Reviews in Microbiology, Год журнала: 2024, Номер unknown, С. 1 - 15
Опубликована: Июль 5, 2024
The gut microbiota features an abundance of diverse microorganisms and represents important component human physiology metabolic homeostasis, indicating their roles in a wide array physiological pathological processes the host. Maintaining balance is critical for normal functionality as microbial dysbiosis can lead to occurrence development diseases through various mechanisms. Long non-coding RNAs (lncRNAs) circular (circRNAs) are that perform regulatory functions many processes. Furthermore, lncRNAs/circRNAs known interact range both activities. In this article, we review existing research relevant interaction between investigate role crosstalk pathogenesis different diseases. Studies have shown that, target lncRNAs ENO1-IT1, BFAL1, LINC00152 regulate colorectal cancer
Язык: Английский
Процитировано
2
Toxicology in Vitro, Год журнала: 2024, Номер 99, С. 105855 - 105855
Опубликована: Май 28, 2024
Язык: Английский
Процитировано
1
Progress in Natural Science Materials International, Год журнала: 2024, Номер 34(5), С. 1009 - 1020
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
0