Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 8, 2024

Abstract RNA‐modifying proteins, classified as “writers,” “erasers,” and “readers,” dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing stability, functionality, interactions. To date, over 170 distinct modifications more than 100 enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has made in understanding modification, the regulatory mechanisms that govern proteins themselves remain insufficiently explored. Post‐translational (PTMs) such phosphorylation, ubiquitination, acetylation are crucial modulating function behavior of proteins. However, full extent PTM influence on their role disease development remains to be fully elucidated. This review addresses gaps offering a comprehensive analysis roles PTMs play regulating Mechanistic insights provided into how alter biological processes, contribute cellular function, drive progression. In addition, current landscape is examined, highlighting therapeutic potential targeting for precision medicine. By advancing networks, this seeks facilitate effective strategies inspire future critical area

Язык: Английский

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Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m6A regulation

Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)

Опубликована: Янв. 23, 2025

Disuse bone loss is prone to occur in individuals who lack mechanical stimulation due prolonged spaceflight or extended bed rest, rendering them susceptible fractures and placing an enormous burden on social care; nevertheless, the underlying molecular mechanisms of caused by unloading have not been fully elucidated. Numerous studies focused epigenetic regulation disuse loss; yet limited research has conducted impact RNA modification formation response conditions. In this study, we discovered that m6A reader IGF2BP1 was downregulated both osteoblasts treated with 2D clinostat tissue HLU mice. Supplementing could promote osteoblast proliferation partially alleviate adverse effects formation. Mechanistically, inhibited degradation Lef1 mRNA directly binding its recognizing modification. Furthermore, LEF1 promoted upregulating c-Myc Cyclin D1 expression, as well participated mediating IGF2BP1-induced activity under unloading. Notably, Melatonin (MT) might participate IGF2BP1/LEF1 axis, thereby regulating Collectively, study revealed a new insight into MT/IGF2BP1/LEF1 pathway process unloading-induced loss, which potentially contribute establishing therapeutic strategies for osteoporosis.

Язык: Английский

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Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Сен. 28, 2024

Язык: Английский

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N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(12)

Опубликована: Дек. 1, 2024

N6-methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing pivotal role various biological functions. Its significance female reproductive development associated diseases has recently become focal point of research.

Язык: Английский

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