Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
290, С. 117587 - 117587
Опубликована: Янв. 1, 2025
Chlorpyrifos
(CPF)
is
a
broad-spectrum
organophosphate
chloride
(OP)
insecticide
widely
used
in
domestic
use
and
open
field.
However,
there
currently
no
relevant
research
revealing
the
toxic
effects
of
CPF
exposure
on
skin,
then
it
necessary
to
comprehensively
understand
mechanisms.
The
results
showed
that
skin
tissue
structure
function
mice
were
significantly
disrupted
after
exposure.
Furthermore,
PPI
network
analysis
molecular
docking
experiments
pinpointed
core
targets
such
as
Bcl2,
EGFR,
Caspase-3,
TNF-α,
IL-1β,
VEGF.
Additionally,
through
KEGG
analysis,
VEGF
apoptosis
signaling
pathways
identified
pivotal
implicated
CPF-induced
toxicity.
These
subsequently
confirmed
animal
experimentation.
In
conclusion,
our
study
suggests
primarily
induces
damage
by
disrupting
function,
mediated
proliferation
processes
cells,
alongside
aberrant
angiogenesis
heightened
inflammatory
response.
insights
are
expected
advance
development
preventive
therapeutic
strategies
aimed
at
mitigating
adverse
skin.
Язык: Английский
Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae
The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109887 - 109887
Опубликована: Фев. 1, 2025
Язык: Английский
Efficient analysis of the toxicity and mechanisms of Hexaconazole and two other triazole fungicides: insights from integrated network toxicology, molecular docking and bioinformatics data
Genome Instability & Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Язык: Английский
Toxicity and mechanistic analysis of Di(2- ethylhexyl)phthalate in renal cell carcinoma Progression: a systematic study with network toxicology and molecular docking strategies
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
Abstract
Millions
of
tons
unrecycled
plastic
are
polluting
landfills
and
oceans,
Di(2-ethylhexyl)
phthalate
(DEHP),
a
plasticizer
classified
as
possible
carcinogen,
is
found
in
many
environments,
posing
health
risks.
Renal
cell
carcinoma
(RCC),
one
the
most
prevalent
malignancies,
recorded
approximately
434,419
new
cases
155,702
deaths
2022.
DEHP
can
cause
developmental
dysregulation,
reproductive
impairments,
tumorigenesis,
transgenerational
diseases;
however,
mechanisms
underlying
these
effects
remain
unclear.
This
study
aimed
to
elucidate
toxic
targets
molecular
associated
with
exposure
RCC
occurrence
by
integrating
network
toxicology
docking,
utilizing
multilevel
bioinformatics
data.
By
systematically
diverse
databases,
82
both
were
identified.
Subsequent
screening
STRING
Cytoscape
highlighted
25
key
targets,
including
CASP3,
BCL2,
MMP9,
BCL2L1,
CTSS,
APP.
GO
KEGG
enrichment
analyses
revealed
that
involved
apoptosis,
abnormal
hormone
activity,
cancer-related
signaling
cascades,
ligand-receptor
interactions,
endocrine
system
pathways.
Molecular
docking
simulations
using
CB-dock
confirmed
high-affinity
binding
interactions
between
targets.
These
results
suggest
may
promote
development
regulating
apoptosis
proliferation
through
pathways
such
neuroactive
interaction,
cancer,
apoptosis.
provides
theoretical
basis
for
understanding
DEHP-induced
renal
carcinogenesis
serves
foundation
future
experimental
studies
validate
computational
predictions
regarding
DEHP-associated
tumor
risks
from
products
environmental
exposure.
Язык: Английский
Predicting the molecular mechanisms of cardiovascular toxicity induced by per- and polyfluoroalkyl substances: an In Silico network toxicology perspective
Toxicology Research,
Год журнала:
2024,
Номер
13(6)
Опубликована: Ноя. 5, 2024
Abstract
Background:
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
human-made
chemicals
that
accumulate
in
the
human
body
environment
over
time.
Humans
primarily
exposed
to
PFAS
through
drinking
water,
food,
consumer
products,
dust.
These
exposures
can
have
many
adverse
health
effects,
including
cardiovascular
diseases
(CVDs)
factors
contributing
CVDs.
This
study
identified
molecular
mechanisms
of
CVDs
caused
by
PFAS.
Methods:
For
this
purpose,
various
computational
tools,
such
as
Comparative
Toxicogenomic
Database,
ShinyGO,
ChEA3,
MIENTURNET,
GeneMANIA,
STRING,
Cytoscape,
were
used
conduct
silico
analyses.
Results:
The
results
showed
10
genes
common
between
CVDs,
among
these
genes,
PPAR
signaling
pathway,
fatty
acid
metabolic
processes,
lipid
binding
most
significantly
associated
gene
ontology
terms.
Among
top
transcription
(TFs)
related
peroxisome
proliferator-activated
receptor
gamma
androgen
prominent.
Additionally,
hsa-miR-130b-3p,
hsa-miR-130a-3p,
hsa-miR-129-5p
featured
microRNAs
involved
PFAS-induced
Finally,
PPARA
PPARG
core
Conclusion:
findings
may
contribute
a
better
understanding
reveal
new
potential
targets
Язык: Английский