Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast DOI Creative Commons

Bingshuo Shi,

Rong Suo,

Wenhua Song

и другие.

BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 16, 2024

The spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF) indicates a prethrombic state that ultimately progresses into thrombus formation. A comprehensive understanding of specific plasma metabolomics characteristics may protect AF from thrombus, particularly the early stage. Through investigation metabolic pathways, we endeavor to uncover metabolomic associated SEC states, and examine differential metabolites by which exert their influence on thrombotic states. Patients were enrolled, participants divided three groups based results echocardiogram: non-SEC, low-SEC high-SEC group. Samples collected subjected non-targeted analysis. analytical process included data quality control, metabolite difference analysis, component Kegg cluster etc. RESULTS: Our phenotype revealed clear pattern between non-SEC. Specifically, identified 35 142 significantly venous plasma, respectively, suggesting be involved pervasive dysregulation degree is more severe than blood. have different compared those without SEC. work promoted mechanism occurrence development SEC, facilitated screening target for its therapeutic intervention, provided evidence prevention treatment or thrombosis AF. also new directions subsequent research related fields. In conclusion, our study not only provides theoretical basis AF, but recommendations daily diet such as balanced intake essential amino acids, avoiding excessive benzoic acid, appropriate inositol. Not applicable.

Язык: Английский

Urolithin B as a renoprotective agent against 5-fluorouracil-induced nephrotoxicity: role of Nrf2/Keap1/HO-1, SIRT1/FOXO3, and NF-кB/TNF-α signaling pathways DOI
Mohammed W. Al-Rabia,

Hani Z. Asfour,

Rasha A. Mansouri

и другие.

Food and Chemical Toxicology, Год журнала: 2024, Номер 195, С. 115129 - 115129

Опубликована: Ноя. 22, 2024

Язык: Английский

Процитировано

3

The reno-protective effect of Empagliflozin against carbon tetrachloride (CCl4)-induced nephrotoxicity in mice halting JNK/MKK4/NRF2/NF-KB pathway DOI

Amany A. Alzokaky,

Shimaa K Saber,

Mennatallah O. Zaki

и другие.

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115439 - 115439

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Protective effect of empagliflozin against paracetamol-induced acute kidney injury through modulation of AMPK/SIRT1/PGC-1α pathway in experimental mice DOI
Esraa M. Mosalam, Hind S. AboShabaan,

Marwa M. Mahfouz

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117382 - 117382

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

HPLC-PDA and in vivo anti-inflammatory potential of isorhamnetin-3-O-β-D-glucoside from Zygophyllum simplex L. DOI
Fatma M. Abdel Bar, Rana Alonazi, Engy Elekhnawy

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 119089 - 119089

Опубликована: Ноя. 9, 2024

Язык: Английский

Процитировано

1

Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast DOI Creative Commons

Bingshuo Shi,

Rong Suo,

Wenhua Song

и другие.

BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 16, 2024

The spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF) indicates a prethrombic state that ultimately progresses into thrombus formation. A comprehensive understanding of specific plasma metabolomics characteristics may protect AF from thrombus, particularly the early stage. Through investigation metabolic pathways, we endeavor to uncover metabolomic associated SEC states, and examine differential metabolites by which exert their influence on thrombotic states. Patients were enrolled, participants divided three groups based results echocardiogram: non-SEC, low-SEC high-SEC group. Samples collected subjected non-targeted analysis. analytical process included data quality control, metabolite difference analysis, component Kegg cluster etc. RESULTS: Our phenotype revealed clear pattern between non-SEC. Specifically, identified 35 142 significantly venous plasma, respectively, suggesting be involved pervasive dysregulation degree is more severe than blood. have different compared those without SEC. work promoted mechanism occurrence development SEC, facilitated screening target for its therapeutic intervention, provided evidence prevention treatment or thrombosis AF. also new directions subsequent research related fields. In conclusion, our study not only provides theoretical basis AF, but recommendations daily diet such as balanced intake essential amino acids, avoiding excessive benzoic acid, appropriate inositol. Not applicable.

Язык: Английский

Процитировано

0