18beta-glycyrrhetinic acid alleviates deoxynivalenol-induced hepatotoxicity by inhibiting GPX4-dependent ferroptosis

Toxicon, Год журнала: 2025, Номер unknown, С. 108228 - 108228

Опубликована: Янв. 1, 2025

Язык: Английский

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Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells

Foods, Год журнала: 2025, Номер 14(2), С. 230 - 230

Опубликована: Янв. 13, 2025

Deoxynivalenol (DON), fumonisin B1 (FB1), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans animals. Single combined exposure of DON, FB1, ZEN leads intestinal toxicity but the toxicology mechanism research is still limited. In this study, we explored cytotoxicity effects ZEN, their combination rat epithelial cell line 6 (IEC-6) cells. Cell viability results showed potency ranking was DON > FB1. Furthermore, both + FB1 presented synergism antagonism based on a index (CI)-isobologram equation model. Integrated metabolomics lipidomics adopted explore metabolism disorders induced by mycotoxin exposure. A total 2011 metabolites 670 lipids were identified. An overlap 37 62 differential compounds confirmed after single multivariate analysis, respectively. Some endocellular antioxidants significantly downregulated groups, indicating metabolic as well antioxidant capacity damage Pathway enrichment analysis annotated ethanol production ROS CYP2E1 mainly involved disturbance ZEN. The obtained study help define singly co-existence, providing an important scientific basis for risk recognition contamination.

Язык: Английский

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Asperdoles A–N: Indole Diterpenoids from the Endolichenic Fungus Aspergillus sp. TJ403-YJ22

Journal of Natural Products, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Fourteen new indole diterpenoids, designated as asperdoles A-N (1-14), were isolated from the endolichenic fungus Aspergillus sp. TJ403-YJ22. Notably, compounds 1-7 characterized by presence of 2-keto-3-hydroxy-oxidized moieties, which connected to diterpenoid segments via methylene bridges. Compounds 1-5 featured fused 6/6/6 ring frameworks, whereas tetrahydropyran in 6-14 was cleaved, resulting formation terminal vicinal diols 6-12 and olefinic double bonds 13 14. The planar structures absolute configurations these elucidated through a combination NMR spectroscopy, HRESIMS, Snatzke's method, single-crystal X-ray diffraction analysis, ECD calculations. Compound 4 exhibited selective FXR agonistic activity, with an EC50 value 4.1 ± 0.3 μM, suggesting its potential therapeutic application treatment cholestasis.

Язык: Английский

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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117530 - 117530

Опубликована: Дек. 13, 2024

Язык: Английский

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