Lactobacillus brevis GKJOY Supplementation Ameliorates Oxidative Stress and Reproductive Dysfunction in Male Rats with Polystyrene Microplastics-Induced Reproductive Toxicity

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4533 - 4533

Опубликована: Май 9, 2025

The growing demand for plastic products has led to an increase in human exposure microplastics (MPs). MPs have been shown detrimental effects on reproductive function, while probiotics demonstrated promise enhancing fertility. This study aimed determine the protective of Lactobacillus brevis GKJOY against damage induced by polystyrene (PS-MPs) male rats. In cell study, LC540 cells were treated with L. postbiotic (PGK), gamma-aminobutyric acid (GABA), and PS-MPs evaluate their viability reactive oxygen species (ROS) production. animal experiment, rats a low dose (GK1X, 50 mg/kg), medium (GK2X, 100 or high (GK4X, 200 mg/kg). results showed that PGK GABA reduced levels ROS protected oxidative stress. contrast, increased had harmful viability. testicular injuries caused disruption hypothalamic–pituitary–gonadal (HPG) axis decrease hormone levels. However, treatment stress pro-inflammatory cytokine levels, restored hormonal imbalances, significant improvements. effectively mitigated due its dual function as probiotic neurotransmitter modulator. conclusion, GKJOY, which functions both producer, may offer superior protection damage.

Язык: Английский

Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118466 - 118466

Опубликована: Июнь 3, 2025

Язык: Английский