The Cyanobacterial Oxadiazine Nocuolin A Shows Broad-Spectrum Toxicity Against Protozoans and the Nematode C. elegans

Microbial Ecology, Год журнала: 2025, Номер 88(1)

Опубликована: Март 4, 2025

Abstract Cyanobacteria, known to be rich sources of valuable natural products (NPs) with relevant biological properties, are a unique subject study the interplay between chemistry and ecology. Cultivation cyanobacteria as isolated strains may only reveal small fraction their NPs. In contrast, investigating microbial interactions from an ecological perspective is particularly fruitful approach unveil both new bioactivity. Cyanobacteria amoebae co-exist in diverse environments, but interaction these organisms has been poorly investigated. Defense strategies against grazer rely on morphological changes including biofilm formation or increased motility; however, secretion toxic metabolites seems more effective this regard. Among most structurally cyanobacterial secondary nocuolin A, 1,2,3-oxadiazine metabolite strain Nodularia sp. LEGE 06071 that exhibits potent anti-proliferative activity several human cancer lines, associated impairment mitochondrial oxidative phosphorylation. work, we show A two well-known model amoebae, Acanthamoeba Dictyostelium , leading encystation decrease viability. addition, lawn grazing assays, observed 06071, producer was not grazed by amoeba, while related strain, which does produce detectable levels was. These results support possible involvement chemical mediator during organisms. Furthermore, also toxicity other protozoan free-living nematode, making it interesting broad-spectrum scaffold for development antiprotozoal anti-helminthic drugs.

Язык: Английский

Consideration of solar radiation as a relevant parameter associated with cyanobacteria in a tropical monomictic aquatic system

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Studies performed in Valle de Bravo (VB) reservoir Mexico record the presence of cyanobacteria proliferation and microcystin LR (MC-LR), both from 1998 to 2022, related mainly two environmental factors, nitrates (NO3) temperature. We propose that these four parameters do not converge seasonally during stratification mixing. also suggest solar radiation as a temperature effector could have greater association between studied. conducted laboratory tests evaluate intensity light (rather than radiation) at different concentrations NO3 observe growth model used, wild-type (M. aeruginosa) producer MC-LR. The objectives this study were prove if there was seasonal relationship MC-LR with vitro assay on cyanobacterium Microcystis aeruginosa Subsequently, microcystin-containing M. cultured proportion (100, 50, 25 5%) simulate variation. results showed algae did proliferate due availability but rather In we observed had effect aeruginosa. role inversely only high radiation. Therefore, conclude governs for cyanobacteria.

Язык: Английский