Production of Fucoxanthin from Microalgae Isochrysis galbana of Djibouti: Optimization, Correlation with Antioxidant Potential, and Bioinformatics Approaches

Marine Drugs, Год журнала: 2024, Номер 22(8), С. 358 - 358

Опубликована: Авг. 6, 2024

Fucoxanthin, a carotenoid with remarkable antioxidant properties, has considerable potential for high-value biotechnological applications in the pharmaceutical, nutraceutical, and cosmeceutical fields. However, conventional extraction methods of this molecule from microalgae are limited terms cost-effectiveness. This study focused on optimizing biomass fucoxanthin production

Язык: Английский

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For cereal bran, rating of antioxidant capacity and screening of xanthine oxidase inhibitor

Bioactive Carbohydrates and Dietary Fibre, Год журнала: 2025, Номер unknown, С. 100476 - 100476

Опубликована: Май 1, 2025

Язык: Английский

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Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight

International Journal of Food Science, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Due to the increasing rate of cancer and undesirable consequences manufactured drugs, there is a growing interest in development natural products as potential remedies. Ferulic acid (FA), phenolic substance, found naturally present Ferula foetida plant’s cell walls with therapeutic activities. The objective this study determine botanical sources, pharmacokinetics, anticancer activity FA its derivatives, focusing on molecular mechanism by using data obtained from literature database. study’s findings suggest that demonstrates promising effects preclinical pharmacological test methods. exhibit showed through underlying mechanisms, including induction oxidative stress, cytotoxic effect, cycle arrest, apoptotic suppression invasion migration, antiproliferative autophagy, genotoxic mutagenic effect regulating different pathways like PI3K/AKT, p38/MAPK/ERK, AKT/mTOR, NF‐ κ B signaling which are involved growth. Additionally, review indicated pharmacokinetic properties FA, indicating lower oral bioavailability affected liver’s fast conjugation process; limitation overcome applying nanoformulation FA. However, additional clinical investigations recommended appropriate effectiveness, safety, human dosage.

Язык: Английский

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EXPRESS: Ferulic acid inhibits tumor proliferation and attenuates inflammation of hepatic tissues in experimentally induced HCC in rats

Journal of Investigative Medicine, Год журнала: 2024, Номер 72(8), С. 900 - 910

Опубликована: Авг. 2, 2024

Hepatocellular carcinoma (HCC) is a prevalent form of primary liver cancer with 5-year survival rate just 18%. Ferulic acid, natural compound found in fruits and vegetables such as sweet corn, rice bran, dong quai, an encouraging drug known for its diverse positive effects on the body, including anti-inflammatory, anti-apoptotic, neuroprotective properties. Our study aimed to investigate potential antitumor ferulic acid inhibit tumor growth inflammation HCC rats. was induced rats by administering thioacetamide. Additionally, some were given 50 mg/kg three times week 16 weeks. Liver function assessed measuring serum alpha-fetoprotein (AFP) examining hepatic tissue sections stained hematoxylin/eosin or anti-hypoxia factor-1α (HIF-1α). The mRNA protein levels HIF-1α, nuclear factor κB (NFκB), necrosis factor-α (TNF-α), mammalian target rapamycin (mTOR), signal transducer activator transcription 3 (STAT3), cMyc, cyclin D1 examined. results showed that increased rats' reducing AFP suppressing nodules. Furthermore, ameliorated appearance vacuolated cytoplasm HCC, reduced apoptotic nuclei, necrotic Finally, decreased expression NFκB, TNF-α, mTOR, STAT3, D1. In conclusion, believed possess properties inhibiting HCC-induced hypoxia through suppression HIF-1α expression. it helps D1, thereby slowing down growth. Lastly, downregulating NFκB TNF-α.

Язык: Английский

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Syringic acid through reduction of inflammation, oxidative injury, and downregulation of NF-κB-IL-6 pathway ameliorates HFD-induced pulmonary toxicity in male Wistar rats

Comparative Clinical Pathology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Язык: Английский

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