Cannabis: Zone Aspects of Raw Plant Components in Sport—A Narrative Review
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 861 - 861
Опубликована: Фев. 28, 2025
Objectives/Background:
The
Cannabis
genus
contain
a
mixture
of
cannabinoids
and
other
minor
components
which
have
been
studied
so
far.
In
this
narrative
review,
we
highlight
the
main
aspects
polarized
discussion
between
abuse
toxicity
versus
benefits
compounds
found
in
sativa
plant.
Methods:
We
investigated
databases
such
as
PubMed,
Google
Scholar,
Web
Science
World
Anti-doping
Agency
(WADA)
documents
for
scientific
publications
that
can
elucidate
heated
related
to
negative
addiction,
organ
damage
improved
sports
performance
medical
benefits,
particularly
athletes,
some
are
promising
nutrients.
Results:
Scientific
arguments
bring
forward
harmful
effects
cannabinoids,
ethical
legislative
their
usage
doping
substances
sports.
present
synthesis
metabolism
cannabis
along
with
identification
methods
routine
anti-doping
tests.
Numerous
studies
attest
beneficial
effects,
could
therapeutic
advantage
athletes
case
injuries.
These
recommend
nutrients,
well
potential
pharmacological
agents.
Conclusions
Future
Perspectives:
From
perspective
both
illegal
use
investigators
sport,
there
many
interpretations,
presented
discussed
review.
Despite
recent
on
species,
is
very
little
research
active
especially
large
groups
compared
placebo.
may
complete
current
vision
topic
clarify
hypotheses
launched
discussions
Язык: Английский
Exploring the Phytochemical and Toxicological Profile of Moroccan Cannabis Sativa L. Leaves Extract: Behavioral, Histological, and Oxidative Stress Assessments
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
350, С. 120058 - 120058
Опубликована: Май 26, 2025
Язык: Английский
Edible cannabis for chronic low back pain: associations with pain, mood, and intoxication
Samantha N Melendez,
Marco Ortiz Torres,
Jonathan K Lisano
и другие.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 24, 2024
Introduction
Cannabis,
commonly
known
for
both
therapeutic
and
intoxicating
effects,
is
gaining
accessibility
on
legal
markets
traction
as
a
potential
alternative
therapy
pain
mediation,
particularly
in
those
suffering
from
chronic
low
back
pain.
However,
the
effectiveness
this
population
of
market
forms
cannabis,
used
edibles,
unknown.
Methods
Therefore,
study
utilized
naturalistic
prospective
design
where
participants
with
intentions
to
initiate
cannabis
use
treatment
were
recruited
self-selected
edible
products
containing
varying
amounts
delta-
9
tetrahydrocannabinol
(THC)
cannabidiol
(CBD).
Products
categorized
CBD-dominant,
THC-dominant,
or
combined
THC
CBD
(THC
+
CBD).
Results
249
[140
female
(56.62%),
mean
(SD)
age
46.30
(16.02),
90%
White]
tracked
over
2
weeks
ad
libitum
assessed
during
acute
administration
session
changes
pain,
mood,
subjective
drug
effects.
During
administration,
significant
correlation
between
dose
short-term
relief
was
found,
suggesting
that
higher
doses
associated
greater
reduction
(
p
<
.05).
In
addition,
levels
effects
.001),
regardless
whether
also
product.
Acute
primarily
tension
.05);
however,
there
no
associations
Over
2-week
period
results
suggested
reductions
across
using
all
cannabis.
trends
more
frequent
CBD-dominant
may
be
perceived
observation
=
.07).
Discussion
These
findings
support
analgesic
anxiolytic
further
suggest
orally-administered
should
continue
evaluated
provide
extended
Clinical
Trial
Registration:
https://clinicaltrials.gov/study/NCT03522324?locStr=Boulder,%20CO&country=United%20States&state=Colorado&city=Boulder&cond=chronic%20low%20back%20pain&intr=Cannabis&rank=1
,
identifier
NCT03522324.
Язык: Английский
Critical Assessment of Clean‐up Procedures Used for Gas Chromatography‐Mass Spectrometry Analysis of Pesticide Residues in Cannabis Inflorescence
Journal of Separation Science,
Год журнала:
2024,
Номер
47(22)
Опубликована: Ноя. 1, 2024
ABSTRACT
Accurate
analysis
of
pesticide
residues
in
such
a
complex
matrix
as
cannabis
is
challenging
task.
The
aim
this
study
was
to
find
an
optimal
way
removing
abundant
co‐extracts
from
Quick,
Easy,
Cheap,
Effective,
Rugged,
and
Safe
extract
prior
its
by
gas
chromatography‐tandem
mass
spectrometry
(GC‐MS/MS).
Out
the
seven
procedures
tested,
clean‐up
with
Supel
QuE
Verde
sorbent
provided
most
satisfactory
performance
characteristics
for
277
targeted
pesticides,
which
highest
number
these
analytes
ever
investigated
within
GC‐MS‐based
focused
on
cannabis.
criteria
set
SANTE/11312/2021
V2
document
were
considered
assess
results
obtained
method
validation.
Recoveries
range
70%–120%
repeatability
≤20%
219
114
pesticides
at
spiking
levels
0.1
0.01
mg/kg,
respectively.
For
deeper
insight
into
function
tested
sorbents
understand
effects
interfering
co‐extracts,
two‐dimensional
GC
coupled
time‐of‐flight
MS
employed
all
purified
extracts.
Co‐eluting
major
phytocannabinoids
free
fatty
acids
shown
be
responsible
high
“chemical
noise”,
increasing
limits
quantification
respective
retention
times.
Since
chemotypes
fairly
differ
phytocannabinoid
content,
effects,
thus
characteristics,
may
vary.
Under
conditions,
validation
recommended
different
chemotypes.
Язык: Английский
Exploring the Diversity of Cannabis Cannabinoid and Non-Cannabinoid Compounds and Their Roles in Alzheimer's Disease: A Review
IBRO Neuroscience Reports,
Год журнала:
2024,
Номер
18, С. 96 - 119
Опубликована: Дек. 20, 2024
Cannabis
sativa
is
recognized
for
its
chemical
diversity
and
therapeutic
potential,
particularly
in
addressing
neurodegenerative
diseases
such
as
Alzheimer's
disease
(AD).
Given
the
complexity
of
AD,
where
single-target
therapies
often
prove
inadequate,
a
multi-target
approach
utilizing
cannabis-derived
compounds
may
offer
promising
alternatives.
This
review
first
highlights
cannabis
by
categorizing
into
cannabinoids
non-cannabinoids.
It
then
examines
studies
investigating
effects
these
on
AD-related
pathological
features.
By
synthesizing
existing
knowledge,
identifying
research
gaps,
facilitating
comparative
analysis,
this
aims
to
advance
future
understanding.
underscores
cannabis's
potential
strategy
contributing
valuable
insights
ongoing
scientific
discussions.
Язык: Английский