Chemical Physics Impact,
Год журнала:
2023,
Номер
7, С. 100373 - 100373
Опубликована: Ноя. 7, 2023
By
the
importance
of
developing
detection
materials
and
devices,
current
work
was
done
to
provide
molecular
insights
into
exploration
amphetamine
(AMP)
adsorbents/sensors
through
density
functional
theory
(DFT)
assessments
carbon
(g-C)
boron
nitride
(g-BN)
graphdiyne
nanosheets.
Since
AMP
could
be
very
harmful
in
an
overdose
level,
then
its
careful
is
important
for
employing
appropriate
emergency
cares
activities.
The
optimization
calculations
were
performed
stabilize
structures
singular
models
their
corresponding
AMP@g-C
AMP@g-BN
complex,
which
a
higher
strength
found
formation
complex.
Bothe
complexes
stable
enough
recognized
based
on
formations
also
by
monitoring
variations
frontier
orbital
features.
results
indicated
that
complex
used
immediately
whereas
timely
detection.
Both
reusable
non-covalent
interactions
between
substances,
stabilities
orbitals
features
proposed
both
g-C
g-BN
nanosheets
as
suitable
adsorbent/sensor
substance
novel
devices.
Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
The
sensitive
detection
of
trace
biomarkers
in
exhaled
breath
for
lung
cancer
diagnosis
represents
a
critical
area
research
life
analytical
chemistry,
with
profound
implications
early
disease
detection,
therapeutic
intervention,
and
prognosis
monitoring.
Despite
its
potential,
the
process
faces
significant
challenges
due
to
ultratrace
levels
present
complex,
high-humidity
composition
breath.
This
study
introduces
highly
method
detecting
aldehyde
by
integrating
use
amino-functionalized
microporous
organic
networks
(NH
Rapid Communications in Mass Spectrometry,
Год журнала:
2023,
Номер
37(S1)
Опубликована: Март 14, 2023
Human
breath
analysis
has
been
attracting
increasing
interest
in
the
detection
of
abused
drugs
forensic
and
clinical
applications
because
its
noninvasive
sampling
distinctive
molecular
information.
Mass
spectrometry
(MS)-based
approaches
have
proven
to
be
powerful
tools
for
accurately
analyzing
exhaled
drugs.
The
major
advantages
MS-based
include
high
sensitivity,
specificity,
versatile
couplings
with
various
methods.Recent
advances
methodological
development
MS
are
discussed.
Breath
collection
sample
pretreatment
methods
also
introduced.Recent
technical
aspects
summarized,
highlighting
active
passive
sampling.
detecting
different
reviewed,
emphasizing
their
features,
advantages,
limitations.
future
trends
challenges
discussed.The
coupling
a
tool
drugs,
offering
highly
attractive
results
investigations.
is
relatively
new
field
still
early
stages
development.
New
technologies
promise
substantial
benefit
analysis.
Advanced Sensor Research,
Год журнала:
2024,
Номер
3(7)
Опубликована: Март 1, 2024
Abstract
While
exhaled
breath
condensate
EBC
is
not
yet
used
in
routine
clinical
diagnostics
and
disease
monitoring,
recent
publications
indicate
that
air
contain
a
wide
range
of
molecular
biomarkers
are
characteristic
various
medical
conditions.
This
includes
evidently
lung
disorders
such
as
asthma,
COPD,
cystic
fibrosis,
but
also
diabetes
several
types
cancer
go
along
with
specific
from
the
airways.
In
addition,
samples
can
be
collected
non‐invasive
way
and,
due
to
their
small
volume,
they
easily
stored
frozen
between
collection
analysis.
Several
home‐made
EBC‐collection
systems
for
research
purposes
documented
literature
while
there
few
commercial
suppliers
certified
products.
this
work,
novel
device
presented
which
condensed
inside
stainless
steel
tubes,
tightly
surrounded
by
an
aluminum
cylinder
precooled
kitchen
freezer.
The
low
cost,
easy
use
patients
at
home
or
clinic,
its
efficiency
up
500
µL
min
−1
respiration
on
high
side.
Analytica Chimica Acta,
Год журнала:
2024,
Номер
1323, С. 342991 - 342991
Опубликована: Авг. 8, 2024
Exhaled
breath
(EB)
aerosol
was
in
principle
shown
to
be
a
suitable
matrix
for
bioanalysis
of
volatile
but
also
non-volatile
compounds.
This
attracted
particular
interest
the
field
drug
analysis.
However,
big
gap
still
exists
understanding
how
and
which
drugs
and/or
their
metabolites
are
excreted
into
exhaled
could
thus
actually
detected.
The
current
study
aimed
develop
an
analytical
workflow
qualitative
detection
EB
microparticles.
The
study
of
volatile
organic
compounds
(VOCs)
in
exhaled
breath
presents
significant
potential
for
noninvasive
disease
diagnosis
and
human
exposure
monitoring.
While
thermal
desorption
(TD)
tubes
are
the
most
commonly
used
preconcentration
technique
analyzing
VOCs
breath,
they
still
face
practical
challenges,
mainly
selective
adsorption
interference
from
water
vapor
samples.
This
is
first
to
develop
a
method
combining
Stirling
cooling
technology
with
gas
chromatography-flame
ionization
detector/mass
spectrometry
(GC-FID/MS)
SUMMA
canister,
enabling
simultaneous
detection
116
VOCs.
requires
no
refrigerants
effectively
addresses
issues
found
TD
tubes.
Furthermore,
nitrogen
pressurization
dilute
original
gas,
calibration
curves
encompassing
various
linear
ranges
developed
quantify
targeted
across
different
concentration
levels.
Finally,
we
analyzed
samples
eight
healthy
subjects
validated
method.
results
showed
that
coefficients
determination
(R
2)
equations
all
target
exceeded
0.998,
limits
quantification
(LOQ)
ranging
0.01
0.09
ppbv
0.03
0.35
ppbv,
respectively,
precision
within
20%.
Accuracy,
except
few
substances,
was
generally
between
70%
130%.
offers
robust
technical
support
accurate
at
levels
breath.
Analytical and Bioanalytical Chemistry,
Год журнала:
2023,
Номер
415(18), С. 3759 - 3768
Опубликована: Апрель 5, 2023
Human
exhaled
breath
is
becoming
an
attractive
clinical
source
as
it
foreseen
to
enable
noninvasive
diagnosis
of
many
diseases.
Because
mask
devices
can
be
used
for
efficiently
filtering
substances,
mask-wearing
has
been
required
in
the
past
few
years
daily
life
since
unprecedented
COVID-19
pandemic.
In
recent
years,
there
a
new
development
wearable
samplers
collecting
substances
disease
and
biomarker
discovery.
This
paper
attempts
identify
trends
analysis.
The
couplings
with
different
(bio)analytical
approaches,
including
mass
spectrometry
(MS),
polymerase
chain
reaction
(PCR),
sensor,
others
analysis,
are
summarized.
developments
applications
human
health
reviewed.
limitations
future
also
discussed.
