Recent Trends in Therapeutic Drug Monitoring of Peptide Antibiotics

Journal of Separation Science, Год журнала: 2024, Номер 47(19)

Опубликована: Окт. 1, 2024

ABSTRACT Antimicrobial peptides take a specific position in the field of antibiotics (ATBs), however, from large number available molecules only few them were approved and are used clinics. These therapeutic modalities play crucial role management diseases caused by multidrug‐resistant bacterial pathogens represent last‐line therapy for infections. Therefore, there is demand rationale use such ATBs based on optimization dosing strategy to minimize risk resistance ensure sustainable efficacy drug real clinical practice. Therapeutic monitoring, as measurement concentration body fluids or tissues, results patient´s medication outcome. This beneficial could result tailored different types infection prolongation hospitals. review paper provides an actual overview antimicrobial practice covers current trends their analysis convenient advanced methodologies identification and/or quantitation biological matrices monitoring purposes. Special emphasis given methods with perspective outcomes.

Язык: Английский

Three-step anionic micelle-to-cyclodextrin stacking for toxic alkaloids analysis in food and herbal samples using citric acid-assisted capillary zone electrophoresis

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 112572 - 112572

Опубликована: Дек. 1, 2024

Язык: Английский