Journal of Separation Science,
Год журнала:
2024,
Номер
47(16)
Опубликована: Авг. 1, 2024
In
this
work,
a
composite
hydrogel
material
consisting
of
chitosan-based
was
prepared
by
simple
and
rapid
synthetic
method
will
be
named
three-dimensional
(3D)-IL-COF-1@CS
hydrogel.
Possessing
stable
3D
network
structure
outstanding
hydrophilicity,
the
novel
is
capable
capturing
glycopeptides.
The
3D-IL-COF-1@CS
showed
good
sensitivity
(0.1
fmol/µL)
selectivity
(1:2000).
addition,
19
glycopeptides
were
captured
in
standard
samples.
analysis
human
serum,
148
assigned
to
72
glycoproteins
assayed
serum
normal
individuals,
245
corresponding
100
found
colorectal
cancer
(CRC)
patients.
More
importantly,
several
functional
programs
based
on
Gene
Ontology
supported
molecular
biological
processes
that
may
relevant
pathogenesis
CRC,
including
aging,
fibrinogen
complex,
arylesterase
activity.
low
cost,
simplicity,
synthesis,
enrichment
performance
have
great
future
glycoproteomics
related
diseases.