The Analyst,
Год журнала:
2024,
Номер
149(17), С. 4322 - 4342
Опубликована: Янв. 1, 2024
Biomedical
silk
protein
optics
has
become
the
subject
of
intensive
research
aimed
at
solving
challenges
associated
with
traditional
medical
devices
in
terms
biocompatibility
and
performance
balance.
ACS Omega,
Год журнала:
2024,
Номер
9(24), С. 26257 - 26266
Опубликована: Июнь 7, 2024
This
study
reports
the
synthesis
of
novel
fluorescent
probes,
phenol-hydrazide-appended
tetraphenylethenes
(TPEs
I
and
II),
explores
their
photochemical
properties.
The
probes
exhibit
aggregation-induced
emission
(AIE)
in
increasing
water
content,
as
observed
using
fluorescence
spectroscopy.
Further
investigation
with
UV–vis
techniques
revealed
potential
ion
sensors.
Both
TPE
II
act
"turn-off"
sensors
for
Cu2+
ions,
showing
decreased
intensity
presence.
Their
limit
detection
(LOD)
association
constant
(Ka)
were
found
to
be
comparable
at
747
nM/597
nM,
2.46
×
105
M–1/2/1.78
M–1/2,
respectively.
Moreover,
quantum
yields
also
calculated
0.651
0.325,
Interestingly,
these
function
"turn-on"
glutathione
(GSH)
presence
copper.
means
can
reversibly
switched
off
on
by
alternating
CuCl2
GSH
additions.
LOD
values
II–Cu2+
544
nM.
In
addition,
employed
visual
analysis
assess
color
alterations
TPEs
filter
paper
real
samples.
Overall,
this
research
introduces
promising
new
applications
copper
biomolecule
sensing
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2969 - 2969
Опубликована: Март 25, 2025
Photodynamic
therapy
(PDT)
is
an
innovative
treatment
that
has
recently
been
approved
for
clinical
use
and
holds
promise
cancer
patients.
It
offers
several
benefits,
such
as
low
systemic
toxicity,
minimal
invasiveness,
the
ability
to
stimulate
antitumor
immune
responses.
For
certain
types
of
cancer,
it
shown
positive
results
with
few
side
effects.
However,
PDT
still
faces
some
challenges,
including
limited
light
penetration
into
deeper
tumor
tissues,
uneven
distribution
photosensitizer
(PS)
can
also
affect
healthy
cells,
difficulties
posed
by
hypoxic
microenvironment
(TME).
In
conditions,
PDT's
effectiveness
reduced
due
insufficient
production
reactive
oxygen
species,
which
limits
destruction
lead
relapse.
This
review
highlights
recent
advances
in
photosensitizers
nanotechnologies
are
being
developed
improve
PDT.
focuses
on
multifunctional
nanoplatforms
nanoshuttles
have
preclinical
studies,
especially
treating
solid
tumors.
One
key
areas
focus
development
PSs
specifically
target
mitochondria
treat
deep-seated
malignant
New
mitochondria-targeting
nano-PSs
designed
better
water
solubility
extended
wavelength
ranges,
allowing
them
tumors
more
effectively,
even
challenging,
environments.
These
advancements
opening
new
doors
treatment,
when
combined
other
therapeutic
strategies.
Moving
forward,
research
should
optimizing
PDT,
creating
efficient
drug
delivery
systems,
developing
smarter
platforms.
Ultimately,
these
efforts
aim
make
a
first-choice
option
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(21)
Опубликована: Авг. 13, 2024
Organic
luminescence
materials
makes
the
molecule
more
enthusiastic
in
wide
variety
of
applications.
The
luminescent
organic
are
a
attraction
researchers,
and
Aggregation-Induced
Emission
(AIE)
is
attributed
to
occurrence
that
particular
chromophores
(typically
fluorophores)
display
very
low
or
nearly
no
emission
monomolecular
soluble
state
but
become
highly
emissive
when
forming
aggregates
solution
solid
state.
This
phenomenon
relatively
abnormal
compared
with
many
other
traditional
fluorophores.
AIE
research
suppresses
aggregation-caused
quenching
(ACQ).
Nevertheless,
carbon
dots
(CDs)
quantum
have
shown
tyical
florescence
properties,
therefore,
recent
years
researchers
also
attracted
for
their
developments.
CDs,
luminescent,
not
only
used
biomedical
applications
light-emitting
diodes
sensing,
self-assembly,
areas.
One
should
introduce
promising
material
designed
framework
exhibits
characteristics
ensure
moral
results
AIE.
Amongest,
AIE-active
tetraphenylethylene
(TPE)
attractive
fluorophores
due
its
easy
synthesis
strategy.
review
article
discusses
properties
TPE,
broad
range
We
outlined
linear,
branched-shaped
supramolecular,
hybrid
macromolecules
potential
future.