Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(5)
Опубликована: Май 1, 2025
ABSTRACT
Early
detection
of
breast
cancer,
the
leading
cause
death
among
women,
is
crucial
for
diagnosis
and
monitoring
during
treatment.
This
study
presents
a
highly
sensitive
selective
aptasensor
designed
to
detect
BRCA1
gene
biomarker
in
phosphate
buffer
solution
human
serum
samples.
The
sensor
was
developed
by
electropolymerizing
o
‐phenylenediamine
with
as
monomer
template,
respectively,
create
molecularly
imprinted
polymer
(MIP)
receptor
film
on
an
ITO
electrode
surface.
Microscopic
techniques
were
employed
thoroughly
characterize
both
non‐imprinted
(NIP)
MIP
films,
before
after
removal
template.
Electrochemical
impedance
spectroscopy
(EIS)
used
measure
changes
charge
transfer
resistance
(Δ
R
ct
),
which
enabled
construction
calibration
curves.
As
concentration
ssDNA
increased
from
100
aM
10
pM,
significant
decrease
observed
limit
30.0
MIP‐modified
electrode.
In
contrast,
NIP‐modified
exhibited
negligible
Δ
within
this
range.
demonstrated
excellent
selectivity,
distinguishing
between
complementary,
three‐base
mismatch,
non‐complementary
sequences.
Moreover,
it
could
sensitively
spiked
samples
across
wide
range
(100
pM)
low
10.0
aM.
Analysis
adsorption
isotherm
diagrams
revealed
that
network's
cavities
binding
sites
uniformly
distributed,
selectively
interacting
high
association
constants
(
K
A
)
over
mismatched
ssDNAs.
MIP/ITO
exceptional
recovery
rates
(ranging
101.5%
105.2%)
along
relatively
standard
deviation
values
(less
than
5%).
These
findings
suggest
platform,
combining
proposed
principle,
offers
reliable
method
detecting
trace
amounts
clinical
cancer
ACS Sensors,
Год журнала:
2024,
Номер
9(5), С. 2254 - 2274
Опубликована: Апрель 18, 2024
Advanced
healthcare
requires
novel
technologies
capable
of
real-time
sensing
to
monitor
acute
and
long-term
health.
The
challenge
relies
on
converting
a
quantitative
biological
chemical
signal
into
desired
measurable
output.
Given
the
success
in
detecting
glucose
commercialization
glucometers,
electrochemical
biosensors
continue
be
mainstay
academic
industrial
research
activities.
Despite
wealth
literature
biosensors,
reports
are
often
specific
particular
application
(e.g.,
pathogens,
cancer
markers,
glucose,
etc.),
most
fail
convey
underlying
strategy
design,
if
it
is
transferable
detection
different
analyte.
Here
we
present
tutorial
review
for
those
entering
this
area
that
summarizes
basic
techniques
utilized
as
well
discusses
designs
optimization
strategies
employed
improve
sensitivity
maximize
Critical Reviews in Analytical Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Фев. 11, 2025
Due
to
their
natural
biocompatibility,
cost-effectiveness,
and
strong
interfacial
adhesion,
biopolymers
have
highly
favorable
properties
for
electrochemical
biosensors.
this
endogenous
catecholamine's
versatile
chemistry,
dopamine's
oxidation
self-polymerization
recently
attracted
considerable
interest.
Polydopamine
(PDA)'s
application
surface
deposition,
molecular
imprinting,
electrochemistry
is
especially
noteworthy.
This
review
aims
propose
the
role
of
PDA
in
quantitative
applications,
evaluate
analytical
performance,
cost,
reproducibility,
versatility
methods
developed,
standard
(bio)analytical
platforms.
First,
parameters
that
influence
polymerization
dopamine
are
discussed.
Then,
different
functionalities
its
recent
applications
biosensing
purposes
reviewed
build
bioanalytical
The
discussion
concludes
with
emerging
PDA-integrated
biosensor
Finally,
future
perspectives
improved
use
ACS Applied Electronic Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
2D
heterostructures,
made
by
stacking
ultrathin
materials,
are
becoming
key
for
advanced
sweat
and
heat
sensors
in
noninvasive
health
monitoring.
These
meticulously
designed
structures
leverage
the
synergistic
properties
of
individual
materials.
Integration
graphene
transition
metal
dichalcogenides
(TMD)
enables
highly
selective
that
monitor
electrolytes,
offering
insights
into
hydration
electrolyte
imbalances.
In
this
regard,
there
is
considerable
versatility
sensor
types,
which
covered
throughout
review.
Some
examples
include
electrochemical
sensors,
enzyme-free,
Joule-heating,
flexible
stretchable,
molecularly
imprinted
polymer
(MIP),
multimodal,
among
others.
On
other
hand,
also
a
plethora
can
be
developed
through
use
heterostructures.
A
widely
explored
material
hexagonal
boron
nitride
(h-BN),
displays
exceptional
thermal
conductivity.
By
combining
h-BN
with
researchers
engineer
heterostructures
accurately
flux,
providing
core
body
temperature
data
thermoregulation
purposes.
However,
challenges
such
as
long-term
stability
biocompatible
integration
remain.
Yet,
sensing
great
terms
types
available,
based
on
thermoresistivity,
expansion,
thermally
induced
phase
change,
optical
heat,
calorimetric,
Even
though
current
to
improvement
their
biocompatibility,
robusticity,
optimization
manufacturing
large-scale
applications,
future
heterostructure-based
bright.
addressing
these
continuously
innovating,
revolutionize
personalized
monitoring,
empower
individuals
track
metrics
real
time,
pave
way
wearable
devices,
ultimately
improving
wellness
management
athletic
performance.
This
review
explores
emerging
applications
heterostructure
nanomaterials
development
The
ability
conveniently
noninvasively
assess
biomarkers
holds
significant
promise
technologies.
discusses
state-of-the-art
material-based
including
recent
advancements
materials
design,
fabrication,
analysis.
Challenges
related
production,
stability,
platforms
discussed.
Finally,
outlines
research
directions,
highlighting
need
developing
cost-effective
fabrication
methods,
integrating
analytics
real-time
monitoring
medicine.
