Novel benzothiazole-based fluorescent probe for efficient detection of Cu2+/S2− and Zn2+ and its applicability in cell imaging

Analytica Chimica Acta, Год журнала: 2024, Номер 1324, С. 343093 - 343093

Опубликована: Авг. 12, 2024

Язык: Английский

---

A Rhodamine-Benzothiophene Based Fluorescent Chemosensor for Hg2+ Detection: Synthesis, Theoretical Calculations, and Investigations in Solutions and Biosystems

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141971 - 141971

Опубликована: Март 1, 2025

Язык: Английский

---

Recent Updates on Diverse Nanoparticles and Nanostructures in Therapeutic and Diagnostic Applications with Special Focus on Smart Protein Nanoparticles: A Review

ACS Omega, Год журнала: 2024, Номер 9(42), С. 42613 - 42629

Опубликована: Окт. 10, 2024

Nanomedicine enables advanced therapeutics, diagnostics, and predictive analysis, enhancing treatment outcomes patient care. The choices development of high-quality organic nanoparticles with relatively lower toxicity are important for achieving medical goals. Among molecules, proteins have been prospected as smart candidates to revolutionize nanomedicine due their inherent fascinating features. advent protein nanoarchitectures, which explore the biomolecular corona, offers new insights into efficient tissue penetration therapeutic potential. This review examines various animal- plant-based nanoparticles, highlighting source, activity, products, unique biomedical applications in regenerative medicine, targeted therapies, gene drug delivery, antimicrobial bioimaging, immunological adjuvants, etc. It provides an extensive discussion on recent across diverse fields well evolving landscape other nanoproducts nanodevices sensitive procedures. Furthermore, this introduces different preparation technologies emphasizing how design construction significantly influence loading capacity, stability, targeting effects. Additionally, we delve user-friendly multifunctional modular bioarchitectures by assembly (PNPs), marking a significant breakthrough therapies. also considers challenges synthetic nanomaterials emergence natural alternatives, nanoparticle research.

Язык: Английский

---

Ferritin nanocage-enabled detection of pathological tau in living human retinal cells

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 21, 2024

Tauopathies, including Alzheimer's disease and Frontotemporal Dementia, are debilitating neurodegenerative disorders marked by cognitive decline. Despite extensive research, achieving effective treatments significant symptom management remains challenging. Accurate diagnosis is crucial for developing therapeutic strategies, with hyperphosphorylated protein units tau oligomers serving as reliable biomarkers these conditions. This study introduces a novel approach using nanotechnology to enhance the diagnostic process tauopathies. We developed humanized ferritin nanocages, nanoscale delivery system, designed encapsulate transport tau-specific fluorophore, BT1, into human retinal cells detecting neurofibrillary tangles in tissue, key marker of The BT1 living was successfully achieved through demonstrating efficient encapsulation derived from induced pluripotent stem cells. Our experiments confirmed colocalization pathological forms cells, highlighting method's potential identifying Using nanocages represents contribution nanobiotechnology, particularly diagnostics. method offers promising tool early detection implications improving exemplifies integration biomedical science, expanding frontiers nanomedicine techniques.

Язык: Английский

---

Recent Advances in Photoswitchable Fluorescent and Colorimetric Probes

Molecules, Год журнала: 2024, Номер 29(11), С. 2521 - 2521

Опубликована: Май 27, 2024

In recent years, significant advancements have been made in the research of photoswitchable probes. These probes undergo reversible structural and electronic changes upon light exposure, thus exhibiting vast potential molecular detection, biological imaging, material science, information storage. Through precisely engineered structures, can toggle between “on” “off” states at specific wavelengths, enabling highly sensitive selective detection targeted analytes. This review systematically presents fluorescent colorimetric built on various photoswitches, primarily focusing types involving photoswitching their and/or signal response processes. It begins with an analysis including photophysical properties, photoisomerization photochromic mechanisms, fundamental design concepts for constructing The article then elaborates applications these detecting diverse targets, cations, anions, small molecules, biomacromolecules. Finally, it offers perspectives current state future development aims to provide a clear introduction researchers field guidance application new, efficient

Язык: Английский

---

Silk fibroin protein-templated gold nanoclusters for in vivo fluorescence imaging

Photochemical & Photobiological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский

---

Recent advances in modification of plant-based proteins for improved encapsulation performance

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114691 - 114691

Опубликована: Апрель 1, 2025

Язык: Английский

---

Engineered Living Energy Materials

Interdisciplinary materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

ABSTRACT To foster sustainable development, a pivotal trend lies in harnessing energy supplies that propel modern economic and societal progress. Recent advancements living materials for applications have sparked groundbreaking research area: engineered (ELEMs), which seamlessly integrate biological artificial systems efficient conversion storage. consolidate this area, herein, we summarize delve into the evolution of ELEMs. Firstly, provide an overview structural features mechanisms employed by bio‐modules spanning proteins, organelles, entire organisms. They can be directly used as components constructing ELEMs or inspirations design such entities. Then, comprehensively review latest strides based on their distinct modes. Finally, discuss challenges confronting envision future trajectories. The progress holds immense potential to catalyze interdisciplinary endeavors encompassing medicine, environmental science, technologies.

Язык: Английский

---

Research Progress on Reactive Small Molecule Fluorescent Probes Based on the Formation and Cleavage of Covalent Bond

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(4), С. 1194 - 1194

Опубликована: Янв. 1, 2025

Язык: Английский

---

Ferritin Nanocage-Enabled Detection of Pathological Tau in Living Human Retinal Cells

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 8, 2024

Background Tauopathies, such as Alzheimer's disease and Frontotemporal Dementia, are debilitating neurodegenerative disorders characterized by cognitive decline. Despite extensive research, effective treatments significant advancements in managing symptoms have been challenging to achieve. Accurate diagnosis is critical for developing therapeutic strategies. Hyperphosphorylated protein units tau oligomers recognized reliable biomarkers these conditions. This study introduces an innovative approach using nanotechnology enhance the diagnostic process tauopathies. We focus on development application of humanized ferritin nanocages, a novel nanoscale delivery system, designed encapsulate transport tau-specific fluorophore, BT1, into human retinal cells, detection neurofibrillary tangles tissue, key marker Results The BT1 living cells was achieved through use system at nanoscale. nanocages demonstrated efficient encapsulation derived from induced pluripotent stem cells. Our experiments successful colocalization with pathological forms highlighting potential this method identifying Conclusions employment probe represents important contribution field nanobiotechnology, especially context diagnostics. offers promising tool early implications improving management exemplifies integration biomedical science, expanding frontiers nanomedicine techniques.

Язык: Английский

---