Integrating machine learning and biosensors in microfluidic devices: A review
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
263, С. 116632 - 116632
Опубликована: Авг. 3, 2024
Microfluidic
devices
are
increasingly
widespread
in
the
literature,
being
applied
to
numerous
exciting
applications,
from
chemical
research
Point-of-Care
devices,
passing
through
drug
development
and
clinical
scenarios.
Setting
up
these
microenvironments,
however,
introduces
necessity
of
locally
controlling
variables
involved
phenomena
under
investigation.
For
this
reason,
literature
has
deeply
explored
possibility
introducing
sensing
elements
investigate
physical
quantities
biochemical
concentration
inside
microfluidic
devices.
Biosensors,
particularly,
well
known
for
their
high
accuracy,
selectivity,
responsiveness.
However,
signals
could
be
challenging
interpret
must
carefully
analysed
carry
out
correct
information.
In
addition,
proper
data
analysis
been
demonstrated
even
increase
biosensors'
mentioned
qualities.
To
regard,
machine
learning
algorithms
undoubtedly
among
most
suitable
approaches
undertake
job,
automatically
highlighting
biosensor
signals'
characteristics
at
best.
Interestingly,
it
was
also
benefit
themselves,
a
new
paradigm
that
is
starting
name
"intelligent
microfluidics",
ideally
closing
benefic
interaction
disciplines.
This
review
aims
demonstrate
advantages
triad
microfluidics-biosensors-machine
learning,
which
still
little
used
but
great
perspective.
After
briefly
describing
single
entities,
different
sections
will
benefits
dual
interactions,
applications
where
reviewed
employed.
Язык: Английский
Future advances of artificial biosensor technology in biomedical applications
Talanta Open,
Год журнала:
2024,
Номер
9, С. 100301 - 100301
Опубликована: Фев. 27, 2024
Recent
advancements
in
synthetic
biology
have
facilitated
the
concept
of
a
cell-based
and
cell-free
biosensing
platform,
which
enables
identification
molecular
signals
encompassing
metal/chemical
to
disease
biomarkers.
The
artificial
sensing
incorporates
both
whole-cell
strategies,
include
highly
regulated
natural
components
exhibit
genetically
encoded
properties.
These
sensors
utilize
protein
expression
release
signalling
molecules
as
result
received
input
facilitate
detection
analytes.
Intending
use
modified
living
cells
or
biosensing,
proposed
study
highlights
importance
biomedical
diagnostics.
article's
first
section
will
explain
types
including
cell-free,
cell-based,
vesicle-based,
paper-based
where
relies
on
cell,
cellular
components,
systems
mostly
involve
transcriptional
translational
machinery.
It
advantages,
disadvantages,
challenges
advancing
approaches.
second
article
elaborates
principle
strategies
involved.
Though
very
few
studies
been
reported
this
topic,
therefore,
current
focuses
that
designed
for
medical
diagnostic
purposes.
review
also
marks
future
field
intelligence,
nanotechnology,
stem
cells,
omics.
Sensing
recently
has
big
impact
diagnosis
well
drug
development
targeted
therapies.
While
newly
developed
biology-based
diagnostics
technologies
still
high
costs,
require
trained
personnel,
suffer
stability
issues
reduce
sensor
performance.
Therefore,
brings
readers'
attention
advances
following
promotes
resolution
future.
Язык: Английский
Next‐Generation Approaches for Biomedical Materials Evaluation: Microfluidics and Organ‐on‐a‐Chip Technologies
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Biological
evaluation
of
biomedical
materials
faces
constraints
imposed
by
the
limitations
traditional
in
vitro
and
animal
experiments.
Currently,
miniaturized
biomimetic
microfluidic
technologies
organ‐on‐chip
systems
have
garnered
widespread
attention
field
drug
development.
However,
their
exploration
context
material
medical
device
development
remains
relatively
limited.
In
this
review,
a
summary
existing
biological
methods,
highlighting
respective
advantages
drawbacks
is
provided.
The
application
materials,
emphasizing
potential
as
highly
models
then
focused.
Finally,
challenges
opportunities
associated
with
utilizing
to
evaluate
are
discussed.
conclusion,
integration
advanced
presents
paradigm
shift
assessment
offering
prospective
more
accurate
predictive
devices.
Язык: Английский
Brain organoids-on-chip for neural diseases modeling: History, challenges and trends
Journal of Pharmaceutical Analysis,
Год журнала:
2025,
Номер
unknown, С. 101323 - 101323
Опубликована: Апрель 1, 2025
Язык: Английский
The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6336 - 6336
Опубликована: Июнь 7, 2024
Cell
monitoring
is
essential
for
understanding
the
physiological
conditions
and
cell
abnormalities
induced
by
various
stimuli,
such
as
stress
factors,
microbial
invasion,
diseases.
Currently,
techniques
detecting
metabolites
originating
from
specific
cells
are
employed
to
obtain
information
on
in
terms
of
human
health.
Although
states
have
traditionally
been
accessed
using
instrument-based
analysis,
this
has
replaced
sensor
systems
equipped
with
new
materials
technologies.
Various
developed
recognizing
biological
markers
proteins
surfaces,
components
plasma
membranes,
secreted
metabolites,
DNA
sequences.
Sensor
classified
into
subclasses,
chemical
sensors
biosensors,
based
used
recognize
targets.
In
review,
we
aim
outline
fundamental
principles
cells,
encompassing
both
biosensors
sensors.
Specifically,
focus
biosensing
types
sensing
signal-transducing
elements
introduce
recent
advancements
applications
biosensors.
Finally,
address
present
challenges
biosensor
prospects
that
should
be
considered
enhance
performance.
review
covers
application
believe
it
can
provide
valuable
insights
researchers
general
readers
interested
its
further
biomedical
fields.
Язык: Английский
Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 19, 2024
Acute
and
requiring
attention
problem
of
oncotheranostics
is
a
necessity
for
the
urgent
development
operative
precise
diagnostics
methods,
followed
by
efficient
therapy,
to
significantly
reduce
disability
mortality
citizens.
A
perspective
way
achieve
personalized
treatment
use
methods
evaluation
individual
drug
load,
properties
specific
tumors
effectiveness
selected
other
actual
features
pathology.
Among
vast
diversity
tumor
types-brain
are
most
invasive
malignant
in
humans
with
poor
survival
after
diagnosis.
brain
glioblastoma
shows
exceptionally
high
mortality.
More
studies
urgently
needed
understand
risk
factors
improve
therapy
approaches.
One
actively
developing
approaches
tumor-on-a-chip
(ToC)
concept.
This
review
examines
achievements
recent
years
field
ToC
system
developments.
The
basics
microfluidic
chips
technologies
considered
context
their
applications
solving
oncological
problems.
Then
basic
principles
cultivation
evaluate
main
challengers
implementation
devices,
growing
cell
cultures
possibilities
observation.
culture
types
advantages
being
analyzed.
modeling
angiogenesis
blood-brain
barrier
(BBB)
on
chip,
principally
important
elements
life
system,
were
detail.
interesting
examples
developments
have
been
presented.
Язык: Английский
Organs-on-chips: Advanced engineered living systems
APL Bioengineering,
Год журнала:
2024,
Номер
8(4)
Опубликована: Дек. 1, 2024
Язык: Английский
Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
unknown, С. 115485 - 115485
Опубликована: Дек. 1, 2024
Cancer
progression
is
significantly
influenced
by
the
complex
interactions
within
tumor
microenvironment
(TME).
Immune
cells,
in
particular,
play
a
critical
role
infiltrating
tumors
from
circulation
and
surrounding
lymphoid
tissues
an
attempt
to
control
their
spread.
However,
they
often
fail
this
task.
Current
vivo
vitro
preclinical
models
struggle
fully
capture
these
intricate
affecting
our
ability
understand
immune
evasion
predict
drugs
behaviour
clinic.
To
address
challenge,
biofabrication
particularly
3D
bioprinting
has
emerged
as
promising
tool
for
modeling
both
system.
Its
incorporate
multiple
cell
types
into
matrices,
enable
tissue
compartmentalization
with
high
spatial
accuracy,
integrate
vasculature
makes
it
valuable
approach.
Nevertheless,
limited
research
focused
on
capturing
tumor-immune
interplay
vitro.
This
review
highlights
composition
significance
of
TME,
architecture
function
tissues,
innovative
approaches
vitro,
while
proposing
concept
extended
TME.
Язык: Английский