Post-crosslinked amino-functionalized molecularly imprinted polymers via click chemistry for selective chiral recognition of S-etodolac

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112983 - 112983

Опубликована: Фев. 1, 2025

Язык: Английский

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Breathable Biomimetic Chiral Porous MOF Thin Films for Multiple Enantiomers Sensing

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Abstract Chiral sensing is essential in pharmaceuticals, food safety, and environmental monitoring, but effectively accurately detecting various enantiomers continues to be a substantial challenge. Inspired by the dynamic conformational change of olfactory receptor proteins, natural L‐carnosine (Car) used as ligand assemble first highly crystalline oriented chiral peptide‐based metal‐organic framework (MOF) thin films with liquid‐phase epitaxial layer‐by‐layer approach (named surfac‐coordinated MOF films, SURMOFs). By adjusting solvent environment, these at same time porous SURMOFs mimic flexibility exhibiting structural changes. This “breathing effect” enables ZnCar selectively sense six fragrance enantiomers, including (+)/(−)‐carvone, (+)/(−)‐menthol, (+)/(−)‐limonene. incorporating into quartz crystal microbalance (QCM) analyzing frequency shifts using convolutional neural networks (CNN), sensitive gravimetric biomimetic sensor capable multiple has been developed. With sensitivity range 10 200 ppm, reached recognition accuracy 98.58% for showcasing outstanding selectivity flexibility.

Язык: Английский

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Development of Acid‐Functionalized Molecularly Imprinted Phenolic Resin for Chiral Recognition of S‐Venlafaxine

Chirality, Год журнала: 2025, Номер 37(3)

Опубликована: Фев. 17, 2025

ABSTRACT This article reports the synthesis of a molecularly imprinted phenolic formaldehyde resin for selective recognition cationic S‐enantiomer venlafaxine. The was developed through condensation polymerization p‐hydroxybenzoic acid (4‐HBA) and 4‐nitrophenol (4‐NP) with in an acidic medium. resultant polymer reduced to introduce amino groups into obtain dual‐functional carboxylic (CA‐P). After uptake S‐VF, glutaraldehyde cross‐linking stabilized formed its enantioselective cavities. Adsorption studies showed that optimum conditions occurred at pH 7, whereas maximum adsorption capacity 420 mg/g according Langmuir isotherm. selectivity coefficient S‐VF‐IP 13 times NIP, confirming imprinting process indeed occurred. Chiral separation experiments using SV‐imprinted (S‐VF‐IP) column resulted 98% enantiomeric excess R‐VF, respective NIP did not provide any enantioselectivity. These results show great possibility efficient offer promising method purification chiral drugs from racemic mixtures pharmaceutical applications.

Язык: Английский

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Post-cationic modification of a pyridyl-based conjugated microporous polymer stationary phase for mixed mode liquid chromatographic separation and food additive detection

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113120 - 113120

Опубликована: Фев. 1, 2025

Язык: Английский

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Fabrication and evaluation of stationary phases with different morphology from two imidazole-based ligands for nonchiral and chiral electrochromatographic separation

Talanta, Год журнала: 2025, Номер 291, С. 127894 - 127894

Опубликована: Март 4, 2025

Язык: Английский

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A dual chiral porous organic polymer synthesized by Thiol-yne Click Chemistry strategy for capillary gas chromatography separations

Analytica Chimica Acta, Год журнала: 2025, Номер 1352, С. 343933 - 343933

Опубликована: Март 14, 2025

Язык: Английский

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Clickable Molecularly Imprinted Carboxylated Phenolic‐Furan Polymer for Selective Recognition of (+)‐Sertraline

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(3)

Опубликована: Март 1, 2025

ABSTRACT This work reports the synthesis of a molecularly imprinted phenolic formaldehyde resin for enantioselective recognition cationic (+)‐sertraline (ST) enantiomer. The polymeric material was synthesized via polymerizing p‐hydroxybenzoic acid (4‐HBA) and 4‐(((furan‐2‐ylmethyl)amino)methyl)phenol (Ph‐NH‐Fu) with in acidic medium further post‐crosslinking Diels–Alder (DA) cycloaddition bis(maleimido)ethane (BMO) improved stability selective binding. optimized adsorption conditions (pH 6–8) resulted maximum capacity 433 mg/g, behavior following Langmuir model. Selectivity studies revealed that polymer (+)‐ST‐IP exhibited 14‐fold higher affinity (+)‐ST than nonimprinted (NIP), confirming success molecular imprinting. Column separation techniques indicated to be 97% enantiomeric excess (ee) eluted (−)‐ST, whereas NIP non‐enantioselective. Structural characterization creation specific sites, thermal analysis demonstrated crosslinked polymer. findings indicate promise as highly effective sorbent application pharmaceuticals, especially chiral purification drugs from racemic mixtures.

Язык: Английский

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Development of carboxylated/thiolated phenolic resin via click chemistry for chiral separation of salbutamol racemate

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132556 - 132556

Опубликована: Март 1, 2025

Язык: Английский

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Design of an amino‐functionalized molecularly imprinted polymer via thiol–maleimide click chemistry for chiral separation of ketoprofen

Polymer International, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract A molecularly imprinted polymer was developed to selectively adsorb S ‐ketoprofen (S‐KP) and chirally separate it from a racemic mixture. Synthesis involves condensation polymerization of 4‐mercaptophenol 4‐nitrophenol with formaldehyde obtain thiolated/nitro‐functionalized that further reduced an amino‐functionalized (HS‐P‐NH 2 ) using sodium dithionite. Finally, the ‐imprinted (S‐KP‐P) prepared by imprinting S‐KP onto HS‐P‐NH , followed post‐crosslinking bis(maleimido)ethane through thiol–maleimide click reaction. Confirmation successful functionalization crosslinking done via structural characterization techniques. Kinetic studies showed reaction second‐order kinetics, thermodynamic analysis indicating spontaneous, exothermic process. In adsorption experiments, S‐KP‐P manifested better enantioselectivity in maximum capacity adsorptions 422 mg g −1 for versus 243 R‐KP. The Langmuir model provided best fit isotherm data, confirming monolayer on homogeneous binding sites. Chiral separation experiments column chromatography demonstrated ability resolve (±)‐KP, yielding 97% enantiomeric excess (ee) R‐KP first elution 94% ee second. contrast, non‐imprinted no enantioselectivity. results confirm potential efficient enantioselective pharmaceutical applications. © 2025 Society Chemical Industry.

Язык: Английский

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Affinity Capillary Electrophoresis Based on Receptor Quasi‐Immobilization for the Study of Interactions Between Drugs and Serum Albumin

Journal of Separation Science, Год журнала: 2025, Номер 48(4)

Опубликована: Апрель 1, 2025

ABSTRACT Herein, a receptor quasi‐immobilization affinity capillary electrophoresis strategy was developed for the first time, using metal–organic frameworks with bio‐macromolecular loading capacity and excellent separation performance, efficient accurate determination of interactions between drugs serum albumin. As proof‐of‐concept demonstration, bovine albumin used as receptor, zeolitic imidazole framework‐8, framework good biocompatibility utilized chromatographic stationary phase well substrate quasi‐stationary protein to investigate sulfonamides. Relying on capability column extension migration time window by quasi‐immobilized binding constants three sulfonamide were successfully determined. The result sulfadiazine > sulfadimethoxine sulfaquinoxaline sodium, which consistent those obtained fluorescence spectrometry traditional electrophoresis. Furthermore, chiral (omeprazole sodium D , L ‐tryptophan) human determined applying electrochromatographic that had been rinsed acetonitrile solution. In summary, method not only enables simultaneous evaluation interaction ligands within complex system but also allows investigation different biomacromolecules multicomponent systems through substitution receptors. Consequently, present study provides novel way facilitate rapid screening active constituents systems.

Язык: Английский

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