Exploring the regulatory role of lncRNA in cancer immunity DOI Creative Commons

Danting Zhan,

Hong-chun Xian

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Авг. 10, 2023

Imbalanced immune homeostasis in cancer microenvironment is a hallmark of cancer. Increasing evidence demonstrated that long non-coding RNAs (lncRNAs) have emerged as key regulatory molecules directly blocking the immunity cycle, apart from activating negative pathways for restraining tumor immunity. lncRNAs reshape via recruitment and activation innate adaptive lymphoid cells. In this review, we summarized versatile mechanisms implicated including inhibition antitumor T cell activation, blockade effector recruitment, disruption homing, immunosuppressive cells, inducing an imbalance between cells (cytotoxic lymphocytes, M1 macrophages, helper type 1 cells) versus (M2 2 myeloid derived suppressor infiltrate tumor. As such, would highlight potential novel targets immunotherapy.

Язык: Английский

Decoding hepatocarcinogenesis from a noncoding RNAs perspective DOI
Mostafa K. Abd El‐Aziz, Alyaa Dawoud, Caroline Joseph Kiriacos

и другие.

Journal of Cellular Physiology, Год журнала: 2023, Номер 238(9), С. 1982 - 2009

Опубликована: Июль 14, 2023

Abstract Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular carcinoma (HCC) has gained lot interest. Yet, underlying mechanistic basis liver tumorigenesis is poorly understood. The role some coding genes and their respective translated proteins, then later on, noncoding RNAs (ncRNAs) such as microRNAs have been extensively studied in context HCC pathophysiology; however, implication long (lncRNAs) circular (circRNAs) indeed less investigated. As subclass ncRNAs which elusive for time ago, lncRNAs was found to be involved plentiful cellular functions DNA, RNA, proteins regulation. Hence, it undisputed that dysregulation profoundly contributes via diverse etiologies. Accordingly, represent hot research topic requires prime focus HCC. In this review, authors discuss breakthrough discoveries involving circRNAs contributed contemporary concepts how these could leveraged potential novel diagnostic prognostic biomarkers. Further, review article sheds light on future trends, thereby discussing pathological roles proliferation, migration, epithelial‐to‐mesenchymal transition. Along line reasoning, recommendations targets exploited achieve effective HCC‐related drug development highlighted.

Язык: Английский

Процитировано

54
Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy DOI Open Access
Tasneem Abaza, Mostafa K. Abd El‐Aziz,

Kerolos Ashraf Daniel

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16484 - 16484

Опубликована: Ноя. 18, 2023

Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) have emerged new paradigm shift in oncology. ICIs, programmed cell death protein 1 (PD-1) inhibitors, provided source of hope for patients advanced HCC. Yet, the eligibility criteria HCC ICIs are still missing piece puzzle. Circular RNAs (circRNAs) recently class non-coding that play fundamental role cancer pathogenesis. Structurally, circRNAs resistant to exonucleolytic degradation longer half-life than their linear counterparts. Functionally, possess capability influence various facets tumor microenvironment, especially at tumor–immune synapse. Notably, been observed control expression molecules within cells, potentially impeding effectiveness ICIs. Therefore, this renders them potential cancer-immune biomarkers diagnosis, prognosis, regimen determinants. In review, authors shed light on structure functional roles and, most importantly, highlight promising immunomodulation

Язык: Английский

Процитировано

42
Let-7a/cMyc/CCAT1/miR-17–5p Circuit Re-sensitizes Atezolizumab Resistance in Triple Negative Breast Cancer through Modulating PD-L1 DOI
Noha A. Selem,

Heba Nafae,

Tamer Manie

и другие.

Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154579 - 154579

Опубликована: Май 29, 2023

Язык: Английский

Процитировано

24
MALAT-1 Is a Key Regulator of Epithelial–Mesenchymal Transition in Cancer: A Potential Therapeutic Target for Metastasis DOI Open Access
Mohamed Ali Hussein,

Kamyab Valinezhad,

Eman Adel

и другие.

Cancers, Год журнала: 2024, Номер 16(1), С. 234 - 234

Опубликована: Янв. 4, 2024

Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) is a long intergenic non-coding RNA (lncRNA) located on chr11q13. It overexpressed in several cancers and controls gene expression through chromatin modification, transcriptional regulation, post-transcriptional regulation. Importantly, MALAT-1 stimulates cell proliferation, migration, metastasis serves vital role driving the epithelial-to-mesenchymal transition (EMT), subsequently acquiring cancer stem cell-like properties developing drug resistance. modulates EMT by interacting with various intracellular signaling pathways, notably phosphoinositide 3-kinase (PI3K)/Akt Wnt/β-catenin pathways. also behaves like sponge for microRNAs, preventing their interaction target genes promoting EMT. In addition, we have used bioinformatics online tools to highlight disparities of between normal samples using data from The Cancer Genome Atlas (TCGA). Furthermore, intricate interplay essential targets progression renders it good candidate therapeutic interventions. Several innovative approaches been exploited MALAT-1, such as short hairpin RNAs (shRNAs), antisense oligonucleotides (ASOs), natural products. This review emphasizes modulating metastasis, stemness, chemoresistance different cancers.

Язык: Английский

Процитировано

12
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance DOI Creative Commons

Dexin Xu,

Wenhai Wang, Duo Wang

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 388 - 406

Опубликована: Фев. 1, 2024

Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) influences crucial hallmarks through intricate molecular mechanisms, including proliferation, invasion, angiogenesis, apoptosis, the epithelial-mesenchymal transition (EMT). The current article highlights involvement of MALAT-1 in drug resistance, making it a potential target overcome chemotherapy refractoriness. It discusses impact on immunomodulatory molecules, such as major histocompatibility complex (MHC) PD-L1, leading immune evasion hindering anti-tumor responses. also plays significant role immunology by regulating diverse cell populations. In summary, is versatile regulator, influencing tumorigenesis, chemoresistance, immunotherapy Understanding its precise mechanisms developing targeted therapies, therapeutic strategies targeting show promise improving treatment outcomes. However, further research needed fully uncover biology translate these findings into clinical applications.

Язык: Английский

Процитировано

12
Puzzling out the role of MIAT LncRNA in hepatocellular carcinoma DOI Creative Commons

Rawan Amr Elmasri,

Alaa A. Rashwan,

Sarah Hany Gaber

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 547 - 559

Опубликована: Янв. 11, 2024

A non-negligible part of our DNA has been proven to be transcribed into non-protein coding RNA and its intricate involvement in several physiological processes highly evidenced. The significant biological role non-coding RNAs (ncRNAs), including long (lncRNAs) variously reported. In the current review, authors highlight multifaceted myocardial infarction-associated transcript (

Язык: Английский

Процитировано

11
Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review DOI Creative Commons
R.A. Youness, Danira Ashraf Habashy,

Nour Khater

и другие.

Non-Coding RNA, Год журнала: 2024, Номер 10(1), С. 7 - 7

Опубликована: Янв. 18, 2024

Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although significant amount work has been conducted on nitric oxide (NO) carbon monoxide (CO) inter-relationship field oncology, research about hydrogen sulfide (H2S) remains its infancy. non-coding RNAs (ncRNAs) reported dominating regulation endogenous machinery system H2S pathological contexts. A growing list microRNAs (miRNAs) long (lncRNAs) are leading way upstream regulators for biosynthesis different mammalian cells during development progression human diseases; therefore, targeting can be great benefit. In current review, authors shed light onto biosynthetic pathways by miRNAs lncRNAs various disorders.

Язык: Английский

Процитировано

10
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma DOI Creative Commons
R.A. Assal, Noha Mousaad Elemam,

Radwa Y. Mekky

и другие.

Translational Oncology, Год журнала: 2024, Номер 45, С. 101961 - 101961

Опубликована: Апрель 17, 2024

Tumor microenvironment is an intricate web of stromal and immune cells creating suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), a formidable barrier towards novel therapeutic approaches recently evading oncology field. this study, main aim was to identify evasion tactics mediated by HCC study epigenetic modulation checkpoints; Programmed death-1 (PD-1)/ death-Ligand 1 (PD-L1) T cell immunoreceptor with Ig ITIM domains (TIGIT)/Cluster Differentiation 155 (CD155) at tumor-immune synapse. Thus, liver tissues, PBMCs sera were collected from Hepatitis C Virus (HCV), as well healthy individuals. Screening performed PD-L1/PD-1 CD155/TIGIT axes in patients. PDL1, CD155, PD-1 TIGIT found be significantly upregulated tissues peripheral blood mononuclear (PBMCs) An array long non-coding RNAs (lncRNAs) microRNAs validated regulate such checkpoints screened. The lncRNAs; CCAT-1, H19, MALAT-1 all sera, PBMCs, patients compared HCV controls. However, miR-944-5p, miR-105-5p, miR-486-5p, miR-506-5p, miR-30a-5p downregulated On tumor side, knocking down lncRNAs-CCAT-1, MALAT-1, or H19-markedly repressed co-expression PD-L1 CD155 accordingly induced cytotoxicity co-cultured primary cells. ectopic expression under-expressed microRNAs; decreased transcript levels no effect on TIGIT. other hand, miR-944-5p miR-105-5p dramatically reduced Finally, studied miRNAs enhanced cytotoxic effects against Huh7 showed highest augmentation for conclusion, highlights co-targeting strategy using mimics, CCAT-1 H19 siRNAs efficiently hampers properties HCC.

Язык: Английский

Процитировано

10
MIAT LncRNA: A multifunctional key player in non-oncological pathological conditions DOI Creative Commons

Yousra Zeinelabdeen,

Tasneem Abaza, Montaser Bellah Yasser

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 447 - 462

Опубликована: Янв. 21, 2024

The discovery of non-coding RNAs (ncRNAs) has unveiled a wide range transcripts that do not encode proteins but play key roles in several cellular and molecular processes. Long noncoding (lncRNAs) are specific class ncRNAs longer than 200 nucleotides have gained significant attention due to their diverse mechanisms action potential involvement various pathological conditions. In the current review article, authors focus on role lncRNAs, specifically highlighting Myocardial Infarction Associated Transcript (MIAT), non-oncological context. MIAT is nuclear lncRNA been directly linked myocardial infarction reported control post-transcriptional processes as competitive endogenous RNA (ceRNA) molecule. It interacts with microRNAs (miRNAs), thereby limiting translation expression target messenger (mRNA) regulating protein expression. Yet, implicated other numerous conditions infarction, including cardiovascular diseases, autoimmune disease, neurodegenerative metabolic many others. this review, emphasize exhibits distinct patterns functions across different emerging diagnostic, prognostic, therapeutic agent. Additionally, highlight regulatory function shed light lncRNAs diseases.

Язык: Английский

Процитировано

9
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology DOI Creative Commons
Noha Mousaad Elemam,

Radwa Y. Mekky,

Gowhar Rashid

и другие.

Expert Reviews in Molecular Medicine, Год журнала: 2024, Номер 26

Опубликована: Янв. 1, 2024

The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of invasion and metastasis. Taking a closer look at tumour-immune microenvironment, complex network crosstalk between infiltrating mediated cytokines, chemokines, exosomal mediators shed ligands present. Cytokines such as interleukins can influence all components tumour microenvironment (TME), consequently promoting suppressing based on their secreting source. Interleukin-10 (IL-10) is interlocked cytokine that has been associated with types malignancies proved to have paradoxical effects. IL-10 multiple functions cellular non-cellular within TME. In this review, authors light regulatory role in TME malignant contexts. Moreover, detailed epigenomic pharmacogenomic approaches for regulation were presented discussed.

Язык: Английский

Процитировано

8