The prognostic value of sialylation-related long non-coding RNAs in lung adenocarcinoma DOI Creative Commons

Beiru Wang,

Chengyu Hou,

Yu Xiang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 17, 2024

Abstract There has been increasing interest in the role of epigenetic modification cancers recently. Among various modifications, sialylation emerged as a dominant subtype implicated tumor progression, metastasis, immune evasion, and chemoresistance. The prognostic significance sialylation-related molecules demonstrated colorectal cancer. However, potential roles regulatory mechanisms lung adenocarcinoma (LUAD) have not thoroughly investigated. Through Pearson correlation, univariate Cox hazards proportional regression, random survival forest model analyses, we identified several long non-coding RNAs (lncRNAs) associated with aberrant including LINC00857, LINC00968, LINC00663, ITGA9-AS1. Based on signatures four lncRNAs, classified patients into two clusters different landscapes using non-negative matrix factorization approach. Collectively, Cluster 1 (C1) exhibited worse prognoses than those 2 (C2), well heavier mutation burden. Functional enrichment analysis showed pro-tumor pathways C1, differing from upregulated Longevity programmed cell death C2. Moreover, profiled infiltration levels important lineages subgroups MCPcounter scores single sample gene set scores, revealing relatively immunosuppressive microenvironment C1. Risk indicated that LINC00857 may serve regulator, while other three lncRNAs be protective contributors. Consistently, observed whereas increased expressive ITGA9-AS1 were Finally, drug sensitivity suggested groups benefit therapeutic strategies, contributing to precise treatment LUAD. By integrating multi-omics data, core successfully established distinguish characterizations. These findings provide some insights underlying mechanism sialylation, offer new stratification way clinical guidance

Язык: Английский

Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma DOI Creative Commons
Zhenfa Zhang, Dingli Wang, Guangyao Zhou

и другие.

Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(2), С. e010787 - e010787

Опубликована: Фев. 1, 2025

Background Lung adenocarcinoma (LUAD) presents significant challenges in prognosis and treatment efficacy evaluation. While post-translational modifications are known to influence tumor progression, their prognostic value LUAD remains largely unexplored. Methods We developed a modification learning signature (PTMLS) using machine techniques, analyzing data from 1231 patients across seven global cohorts. The signature’s predicting immunotherapy response was evaluated 12 cohorts spanning multiple cancer types (n=1201). An in-house tissue cohort (n=171) used validate beta-1,4-galactosyltransferase 2’s (B4GALT2’s) significance. role of B4GALT2 immune exclusion investigated through vivo vitro experiments. Results established PTMLS exhibited exceptional predictive capabilities patient outcomes, surpassing the 98 existing indicators. system’s validated diverse malignancy categories for immunotherapeutic assessment. From biological perspective, correlations were observed between immunological parameters, whereby elevated levels characterized by attenuated responses immunologically cold neoplastic features. Within framework, identified as crucial molecular component (r=0.82, p<0.05), its heightened expression linked unfavorable clinical outcomes cases, particularly specimens exhibiting CD8-depleted phenotypes. spatial distribution patterns cell populations, specifically CD8+ T lymphocytes CD20+ B lymphocytes, elucidated multiplexed immunofluorescence analysis. Laboratory investigations subsequently B4GALT2’s regulatory on cellular expansion both laboratory cultures animal models. Significantly, suppression found enhance lymphocyte populations functional status, thereby potentiating anti-programmed death protein 1 studies. This phenomenon reduced CD62L+CD8 alongside GZMB+/CD44+/CD69+CD8 populations. Conclusion system represents an effective instrument individualized evaluation stratification identification previously unrecognized oncogenic factor involved novel therapeutic avenue optimization.

Язык: Английский

Процитировано

3
The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives DOI
Youming Chen,

Zuli Jiang,

Ying Yang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126773 - 126773

Опубликована: Сен. 9, 2023

Язык: Английский

Процитировано

23
PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells DOI

Qingqiong Luo,

Sheng Hu, Yijie Tang

и другие.

Current Cancer Drug Targets, Год журнала: 2024, Номер 24(10), С. 1047 - 1060

Опубликована: Фев. 1, 2024

Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in head and neck. Elucidating molecular mechanisms underlying OSCC occurrence development important for therapy. Dysregulated palmitoylation-related enzymes have been reported several but OSCC.

Язык: Английский

Процитировано

3
The prognostic value of sialylation-related long non-coding RNAs in lung adenocarcinoma DOI Creative Commons

Beiru Wang,

Chengyu Hou,

Yu Xiang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 17, 2024

Abstract There has been increasing interest in the role of epigenetic modification cancers recently. Among various modifications, sialylation emerged as a dominant subtype implicated tumor progression, metastasis, immune evasion, and chemoresistance. The prognostic significance sialylation-related molecules demonstrated colorectal cancer. However, potential roles regulatory mechanisms lung adenocarcinoma (LUAD) have not thoroughly investigated. Through Pearson correlation, univariate Cox hazards proportional regression, random survival forest model analyses, we identified several long non-coding RNAs (lncRNAs) associated with aberrant including LINC00857, LINC00968, LINC00663, ITGA9-AS1. Based on signatures four lncRNAs, classified patients into two clusters different landscapes using non-negative matrix factorization approach. Collectively, Cluster 1 (C1) exhibited worse prognoses than those 2 (C2), well heavier mutation burden. Functional enrichment analysis showed pro-tumor pathways C1, differing from upregulated Longevity programmed cell death C2. Moreover, profiled infiltration levels important lineages subgroups MCPcounter scores single sample gene set scores, revealing relatively immunosuppressive microenvironment C1. Risk indicated that LINC00857 may serve regulator, while other three lncRNAs be protective contributors. Consistently, observed whereas increased expressive ITGA9-AS1 were Finally, drug sensitivity suggested groups benefit therapeutic strategies, contributing to precise treatment LUAD. By integrating multi-omics data, core successfully established distinguish characterizations. These findings provide some insights underlying mechanism sialylation, offer new stratification way clinical guidance

Язык: Английский

Процитировано

2