A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer

Oncology Reviews, Год журнала: 2025, Номер 19

Опубликована: Фев. 12, 2025

Breast cancer is the most prevalent neoplasm in women. ER + (Luminal subtype), representing over 70% of breast tumors, a genetically diverse group. Structural and Numerical-Chromosomal instability initiates tumor development recognized as primary driver genetic alteration luminal tumors. Genomic refers to increased tendency cells accumulate genomic alterations during cell proliferation. The cycle check-point response constant stable drives this process. impact CNV patterns aneuploidies proliferation perturbation has recently been highlighted by scientists Luminal chromosomal on therapy prognosis not new concept. Still, degree emerging leads following deregulation could be predicted CNVs-based reclassification In review, we try explain effect CIN that ended with altered decision-making for strategy patients cancer.

Язык: Английский

Mesenchymal stem/stromal cells: dedicator to maintain tumor homeostasis

Human Cell, Год журнала: 2024, Номер 38(1)

Опубликована: Ноя. 28, 2024

Язык: Английский