Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10246 - 10270
Опубликована: Май 7, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10246 - 10270
Опубликована: Май 7, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Июль 1, 2022
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that accelerates progression. Despite pivotal fighting microbes, seems to suppress antitumor immunity via regulation host cell tumor microenvironment. Although most link activation extracellular space, discovery intracellular complement, raises question: what is relevance this process for malignancy? Intracellular survival immune cells. Therefore, can be important and growth regardless immunosuppression. On other hand, because (the complosome) indispensable T cells, these functions will essential priming responses. Here, we review with consideration extra pathways spatial distribution proteins tumors periphery our take on potential significance as biomarker target therapy.
Язык: Английский
Процитировано
29Science Immunology, Год журнала: 2023, Номер 8(89)
Опубликована: Ноя. 17, 2023
Myeloid cells facilitate T cell immune evasion in cancer yet are pliable and have antitumor potential. Here, by cotargeting myeloid activation molecules, we leveraged the compartment as a therapeutic vulnerability mouse models of pancreatic cancer. solid tumors expressed receptors including pattern recognition receptor Dectin-1 TNF superfamily member CD40. In checkpoint inhibitor-resistant cancer, coactivation Dectin-1, via systemic β-glucan therapy, CD40, with agonist antibody treatment, eradicated established induced immunological memory. Antitumor activity was dependent on cDC1s but did not require classical cell-mediated cytotoxicity or blockade molecules. Rather, targeting CD40 drove IFN-γ signaling, which converged to program distinct macrophage subsets tumor responses. Thus, productive surveillance resistant inhibition can be invoked complementary signaling pathways.
Язык: Английский
Процитировано
21British Journal of Cancer, Год журнала: 2023, Номер 128(6), С. 1117 - 1133
Опубликована: Янв. 11, 2023
Язык: Английский
Процитировано
19Cell & Bioscience, Год журнала: 2024, Номер 14(1)
Опубликована: Март 21, 2024
Abstract Background Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1–4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within environment remain poorly understood, reliable prognostic markers elusive. Therefore, in-depth exploration (TME) identification predictive are crucial for improving clinical management patients. Results Our analysis single-cell RNA-sequencing data from samples unveiled immunosuppressive role tumor-associated macrophages (TAMs), mediated through intricate interactions with cells lymphocytes. We also discovered heterogeneity TAMs, among which group TAMs named TAM-SPP1 demonstrated significant association Epidermal Growth Factor Receptor ( EGFR ) amplification, impaired T cell response survival Furthermore, by leveraging genomic transcriptomic Cancer Genome Atlas (TCGA) dataset, two distinct molecular subtypes different constitution status outcomes were identified. Exploiting differences between these subtypes, we developed four-gene-based model. This model displayed strong associations an elevated level could be used predict anti-tumor prognosis in Conclusion findings illuminated mechanisms that shape gliomas, providing novel insights potential therapeutic targets. holds promise predicting immunotherapy assisting more precise risk stratification Graphical abstract
Язык: Английский
Процитировано
9Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10246 - 10270
Опубликована: Май 7, 2024
Язык: Английский
Процитировано
7