Acta chimica slovenica,
Год журнала:
2023,
Номер
70(4), С. 651 - 660
Опубликована: Дек. 15, 2023
In
2020,
around
19.3
million
new
cancer
cases
resulted
in
3.5
deaths.
It
is
estimated
that
there
will
be
28.4
by
2040.
Plant-derived
natural
products,
such
as
alkaloids,
flavonoids,
terpenoids,
and
phenolic
compounds,
offer
a
wide
range
of
chemical
structures
biological
activities
can
explored
for
their
potential
research.
particular
study,
researchers
investigated
the
anticancer
effects
Fallopia
flower
extracts
on
induced
TAA
(a
carcinogen).
They
examined
to
identify
specific
amino
acids
with
antioxidant
properties
assessed
impact
liver
function
tissue
structure.
The
results
showed
plant
had
positive
histological
section
TAA-treated
group.
Additionally,
group
male
rats
treated
chemotherapy
drug
called
MMC
displayed
effects.
Similarly,
TAA,
extract,
also
These
findings
suggest
extract
from
flowers
could
considered
traditional
therapy
properties.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 29, 2025
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
form
of
primary
liver
cancer,
notoriously
refractory
to
conventional
chemotherapy.
Historically,
sulfane
sulfur-based
compounds
have
been
explored
for
treatment
HCC,
but
their
efficacy
has
underwhelming.
We
recently
reported
a
novel
sulfur
donor,
PSCP,
which
exhibited
improved
chemical
stability
and
structural
malleability.
This
study
aimed
investigate
effects
PSCP
on
HCC
elucidate
underlying
mechanisms.
utilized
bioinformatics
algorithms
clustering,
function
enrichment,
feature
screening
survival
analysis
proteomic
data
from
Cancer
Proteome
Atlas
(CPTAC)
transcriptomic
Genome
(TCGA).
The
impact
was
assessed
in
vitro
vivo,
focusing
expression
activity
p53
AMP-activated
protein
kinase
(AMPK),
as
well
mitochondrial
function.
molecular
target
identified
using
Autodock,
binding
interactions
were
visually
analyzed.
Sulfur
metabolism
found
be
reprogrammed
with
downregulation
sulfur-related
pathways
correlating
poor
patient
prognosis.
significantly
inhibited
tumor
growth
an
allograft
model,
reduced
cell
viability
proliferation,
induced
apoptosis.
potently
increased
AMPK
phosphorylation
SNU398
cells.
suppression
diminished
PSCP-induced
upregulation.
also
impaired
by
inhibiting
respiratory
complex
I,
Ndus3
likely
being
PSCP's
action.
Supplementation
ATP
countered
injury.
Our
findings
suggest
that
reprogramming
metabolic
pivotal
HCC.
presents
promising
therapeutic
strategy
activating
AMPK-p53
signaling
axis.
The
interplay
between
genetic
alterations
and
metabolic
dysregulation
is
increasingly
recognized
as
a
pivotal
axis
in
cancer
pathogenesis.
Both
elements
are
mutually
reinforcing,
thereby
expediting
the
ontogeny
progression
of
malignant
neoplasms.
Intriguingly,
recent
findings
have
highlighted
translocation
metabolites
enzymes
from
cytoplasm
into
nuclear
compartment,
where
they
appear
to
be
intimately
associated
with
tumor
cell
proliferation.
Despite
these
advancements,
significant
gaps
persist
our
understanding
their
specific
roles
within
milieu,
modulatory
effects
on
gene
transcription
cellular
proliferation,
intricacies
coordination
genomic
landscape.
In
this
comprehensive
review,
we
endeavor
elucidate
regulatory
landscape
signaling
domain,
namely
involving
enzymes.
We
explore
molecular
mechanisms
through
which
flux
enzymatic
activity
impact
critical
processes,
including
epigenetic
modulation,
DNA
damage
repair,
expression
regulation.
conclusion,
underscore
paramount
significance
biology
enumerate
potential
therapeutic
targets,
pharmacological
interventions,
implications
for
clinical
applications.
Importantly,
emergent
not
only
augment
conceptual
tumoral
metabolism
but
also
herald
innovative
paradigms
targeting
metabolism-genome
transcriptional
axis.
Cell Death and Differentiation,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
The
impact
of
amino
acids
on
tumor
immunotherapy
is
gradually
being
uncovered.
In
this
study,
we
screened
various
essential
and
non-essential
found
that
methionine
enhances
mRNA
methylation
reduced
the
activation
Type
I
interferon
pathway
in
bladder
cancer.
Through
RNA
sequencing,
point
mutations,
MB49
mouse
models,
single-cell
demonstrated
high
levels
elevate
expression
m
6
A
reader
YTHDF1,
promoting
degradation
RIG-I,
thereby
inhibiting
RIG-I/MAVS-mediated
IFN-I
reducing
efficacy
immunotherapy.
Additionally,
immunoprecipitation
mass
spectrometry
revealed
YTHDF1
binds
to
eukaryotic
translation
initiation
factor
eIF5B,
which
acts
PD-L1
enhance
its
promote
immune
evasion.
By
intravesical
administration
oncolytic
bacteria
VNP20009,
effectively
depleted
locally,
significantly
prolonging
survival
enhancing
cell
infiltration
differentiation
within
tumors.
Multiplex
immunofluorescence
assays
cancer
patients
confirmed
our
findings.
Our
research
elucidates
two
mechanisms
by
inhibits
proposes
a
targeted
depletion
strategy
advances
while
minimizing
nutritional
patients.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 2, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
the
most
common
form
of
primary
liver
cancer
and
remains
refractory
to
conventional
chemotherapy.
Sulfane
sulfur-based
compounds
have
a
long
history
in
treatment
HCC,
but
their
efficacy
has
been
disappointing.
We
recently
reported
sulfane
sulfur
donor
PSCP,
which
exhibits
improved
chemical
stability
allows
for
greater
structural
modification.
This
study
aimed
investigate
effects
PSCP
on
HCC
elucidate
underlying
mechanisms.
Bioinformatics
algorithms,
including
clustering,
function
enrichment,
feature
screening,
survival
analysis
were
employed
analyze
Cancer
Proteome
Atlas
(CPTAC)
proteomic
data
The
Genome
(TCGA)
transcriptomic
sequencing
gene
expression.
impact
assessed
both
vitro
vivo.
evaluated
expression
activity
p53
AMP-activated
protein
kinase
(AMPK),
as
well
mitochondrial
function.
molecular
target
was
identified
using
Autodock,
binding
interaction
visually
analyzed.
In
metabolism
found
be
reprogrammed
downregulation
sulfur-related
pathways
associated
with
poor
patient
prognosis.
inhibited
tumor
growth
an
allograft
model,
reduced
cell
viability
proliferation,
induced
apoptosis.
Moreover,
promoted
AMPK
phosphorylation
by
inhibiting
respiratory
complex
I.
Collectively,
our
findings
suggest
that
reprogramming
metabolic
key
factor
emerges
effective
therapeutic
strategy,
activating
mitochondrial-AMPK-p53
signaling
axis.
KEYWORDS:
Metabolic
reprogramming;
carcinoma;
sulfur;
Mitochondrial
complex;
AMPK;
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
form
of
primary
liver
cancer,
notoriously
refractory
to
conventional
chemotherapy.
Historically,
sulfane
sulfur-based
compounds
have
been
explored
for
treatment
HCC,
but
their
efficacy
has
underwhelming.
We
recently
reported
a
novel
sulfur
donor,
PSCP,
which
exhibited
improved
chemical
stability
and
structural
malleability.
This
study
aimed
investigate
effects
PSCP
on
HCC
elucidate
underlying
mechanisms.
utilized
bioinformatics
algorithms
clustering,
function
enrichment,
feature
screening
survival
analysis
proteomic
data
from
Cancer
Proteome
Atlas
(CPTAC)
transcriptomic
Genome
(TCGA).
The
impact
were
assessed
in
vitroand
vivo,
focusing
expression
activity
p53
AMP-activated
protein
kinase
(AMPK),
as
well
mitochondrial
function.
molecular
target
was
identified
using
Autodock,
binding
interactions
visually
analyzed.
Sulfur
metabolism
found
be
reprogrammed
in
with
downregulation
sulfur-related
pathways
correlating
poor
patient
prognosis.
significantly
inhibited
tumor
growth
an
allograft
model,
reduced
cell
viability
proliferation,
induced
apoptosis.
potently
increased
AMPK
phosphorylation
SNU398
cells.
suppression
diminished
PSCP-induced
upregulation.
also
impaired
by
inhibiting
respiratory
complex
I.
supplementation
ATP
countered
injury.
Our
findings
suggest
that
reprogramming
metabolic
pivotal
HCC.
presents
promising
therapeutic
strategy
activating
mitochondrial-AMPK-p53
signaling
axis.
Archives of Pharmacy Practice,
Год журнала:
2024,
Номер
15(3), С. 23 - 27
Опубликована: Янв. 1, 2024
The
negative
effect
of
vibration,
as
the
main
physical
production
factor,
should
be
thoroughly
investigated.
In
this
scientific
work,
general
vibration
on
protein
metabolism
in
body
is
studied
using
example
laboratory
animals.
2
series
experiments
were
conducted
30
white
rats
kept
same
conditions.
At
time,
animals
group
1
exposed
to
unlike
2.
Animals
a
vertical
sinusoidal
vibrati
