Tumor-Agnostic Therapies in Practice: Challenges, Innovations, and Future Perspectives

Cancers, Год журнала: 2025, Номер 17(5), С. 801 - 801

Опубликована: Фев. 26, 2025

This review comprehensively analyzes the current landscape of tumor-agnostic therapies in oncology. Tumor-agnostic are designed to target specific molecular alterations rather than primary site tumor, representing a shift cancer treatment. We discuss recent approvals by regulatory agencies such as FDA and EMA, highlighting that have demonstrated efficacy across multiple types sharing common alterations. delve into trial methodologies underpin these approvals, emphasizing innovative designs basket trials umbrella trials. These present unique advantages, including increased efficiency patient recruitment ability assess drug diverse populations rapidly. However, they also entail certain challenges, need for robust biomarkers complexities requirements. Moreover, we examine promising prospects developing rare cancers exhibit targets typically associated with more prevalent malignancies. By synthesizing insights, this underscores transformative potential It offers pathway personalized treatment transcends conventional histology-based classification.

Язык: Английский

Advancing the frontier of artificial intelligence on emerging technologies to redefine cancer diagnosis and care

Computers in Biology and Medicine, Год журнала: 2025, Номер 191, С. 110178 - 110178

Опубликована: Апрель 14, 2025

Язык: Английский