The Role of Methyl Canthin-6-one-2-carboxylate in Targeting the NLRP3 Inflammasome in Rheumatoid Arthritis Treatment DOI Creative Commons

Chung‐Che Tsai,

Tin-Yi Chu, Po-Chih Hsu

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 254 - 254

Опубликована: Апрель 7, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, joint destruction, and systemic complications. The nucleotide-binding domain, leucine-rich repeat family, pyrin domain-containing-3 (NLRP3) inflammasome plays pivotal role in RA pathogenesis driving the release of pro-inflammatory cytokines exacerbating oxidative stress. Recent studies identified methyl canthin-6-one-2-carboxylate (Cant) as potential therapeutic agent that modulates NLRP3 pathway. This review explores mechanistic Cant treatment, particularly its effect on stress, macrophages, inflammatory signaling pathways. Additionally, we discuss alternative complementary approaches, such gut microbiota modulation mesenchymal stem cell-based therapies, management RA. Although preliminary findings suggest exhibits promising anti-inflammatory effects, further preclinical clinical are necessary to validate efficacy. Future research should focus optimizing dosage, exploring combination elucidating broader implications targeting for treatment.

Язык: Английский

The Role of Methyl Canthin-6-one-2-carboxylate in Targeting the NLRP3 Inflammasome in Rheumatoid Arthritis Treatment DOI Creative Commons

Chung‐Che Tsai,

Tin-Yi Chu, Po-Chih Hsu

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 254 - 254

Опубликована: Апрель 7, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, joint destruction, and systemic complications. The nucleotide-binding domain, leucine-rich repeat family, pyrin domain-containing-3 (NLRP3) inflammasome plays pivotal role in RA pathogenesis driving the release of pro-inflammatory cytokines exacerbating oxidative stress. Recent studies identified methyl canthin-6-one-2-carboxylate (Cant) as potential therapeutic agent that modulates NLRP3 pathway. This review explores mechanistic Cant treatment, particularly its effect on stress, macrophages, inflammatory signaling pathways. Additionally, we discuss alternative complementary approaches, such gut microbiota modulation mesenchymal stem cell-based therapies, management RA. Although preliminary findings suggest exhibits promising anti-inflammatory effects, further preclinical clinical are necessary to validate efficacy. Future research should focus optimizing dosage, exploring combination elucidating broader implications targeting for treatment.

Язык: Английский

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