Dual therapy with remdesivir plus extended nirmatrelvir/ritonavir in immunocompromised and critically ill patient with suspected persistent COVID-19 infection: Case report
Medicina Intensiva,
Год журнала:
2025,
Номер
49(3), С. 174 - 177
Опубликована: Март 1, 2025
Язык: Английский
Fresh frozen plasma for neutralizing SARS-CoV-2: “An exploratory cross-sectional study and review of the state of the art”
Enfermedades Infecciosas y Microbiología Clínica,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Antiviral combination treatment strategies for SARS-CoV-2 infection in immunocompromised patients
Current Opinion in Infectious Diseases,
Год журнала:
2024,
Номер
37(6), С. 506 - 517
Опубликована: Окт. 23, 2024
Purpose
of
review
The
purpose
this
is
to
report
the
available
evidence
regarding
use
combination
regimens
antivirals
and/or
antibody-based
therapy
in
treatment
SARS-CoV-2
immunocompromised
patients.
Recent
findings
Literature
search
identified
24
articles,
excluding
single
case
reports,
which
included
mainly
patients
with
hematological
malignancies
B-cell
depletion.
Data
were
divided
based
on
timing
and
reason
for
administration
treatment,
that
is,
early
prevent
progression
severe
COVID-19
prolonged
or
relapsed
infection.
We
described
treated
populations,
duration
composition
treatment.
briefly
addressed
new
options
we
proposed
an
algorithm
management
infection
affected
by
malignancies.
Summary
Combination
seems
effective
(73–100%)
well
tolerated
(<5%
reported
bradycardia,
hepatotoxicity,
neutropenia)
strategy
treating
prolonged/relapsed
infections
host,
although
its
optimal
cannot
be
defined
currently
evidence.
role
as
at
a
high
risk
disease/persistent
shedding
requires
further
from
comparison
monotherapy,
even
though
efficacy
was
combinations
plus
mAbs
previous
viral
variants.
Язык: Английский
Dual therapy with remdesivir plus extended nirmatrelvir/ritonavir in immunocompromised and critically ill patient with suspected persistent COVID-19 infection: Case report
Medicina Intensiva (English Edition),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
COVID -19: On the threshold of the fifth year. The situation in Spain
Revista Española de Quimioterapia,
Год журнала:
2023,
Номер
37(1), С. 17 - 28
Опубликована: Ноя. 27, 2023
Despite
having
emerged
from
pandemic
status,
the
incidence
of
COVID-19
episodes
has
recently
increased
in
Spain,
including
pediatric
cases
and
admissions
to
Intensive
Care
Units.
Several
recombinant
variants
are
circulating
among
us,
particularly
XBB
arising
two
Omicron
BA.2
sublineages
with
mutations
genes
encoding
spicule
proteins
that
could
increase
binding
ACE2
receptor
be
more
prone
immune
escape.
Faced
these,
3
pharmaceutical
companies
have
developed
vaccines
adapted
XBB.1.5
sublineage
already
available
for
administration
our
setting
risks
should
not
different
those
previous
mRNA
clearly
favorable
benefit/risk
ratios.
They
applied
patients
potential
poor
evolution
collectives
a
particular
relationship
proximity
them.
Their
application
understood
only
perspective
individual
convenience
but
also
collective
responsibility.
The
most
convenient
seems
simultaneous
immunization
influenza
environment.
In
therapeutic
aspect,
there
is
little
expect
right
now
antisera,
known
antiviral
drugs
still
indicated,
although
their
efficacy
will
reevaluated
due
impact
on
populations
mostly
immunized
better
prognosis
than
past.
opinion,
it
necessary
continue
make
reasonable
timely
use
masks
other
non-pharmacological
means
protection.
Язык: Английский
Antiviral treatment for SARS-CoV-2 infection in the current situation: a position paper of the Spanish Society of Emergency Medicine (SEMES)
Emergencias,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 16, 2024
COVID-19
continues
to
pose
a
significant
threat:
mortality
stands
at
nearly
twice
that
of
influenza,
and
the
incidence
rate
is
growing
as
population's
vaccination
decreases,
particularly
in
Spain
other
areas
Europe.
Given
this
situation,
it
vitally
important
know
whether
medical
protocols
are
consistent
appropriately
implemented
by
health
care
staff
interest
preventing
possible
inefficiency
or
inequity.
Physicians
from
hospital
emergency
departments
met
study
their
hospitals'
usual
clinical
practices
for
managing
SARS-CoV-2
infection
determine
expert
opinions
on
use
antiviral
agents.
The
participating
physicians
then
reached
consensus
evidencebased
recommendations
strategies
would
optimize
treatment.
Язык: Английский
COVID-19 in patients with haematologic malignancies: Effect of RNAemia on clinical outcome in vaccinated patients
International Journal of Infectious Diseases,
Год журнала:
2024,
Номер
146, С. 107163 - 107163
Опубликована: Июль 3, 2024
Язык: Английский
Antiviral Stewardship in Transplantation
Viruses,
Год журнала:
2024,
Номер
16(12), С. 1884 - 1884
Опубликована: Дек. 5, 2024
Though
antimicrobial
stewardship
programs
(ASPs)
are
required
for
hospitals,
the
involvement
of
transplant
recipients
in
programmatic
interventions,
protocols,
and
metrics
has
historically
been
limited.
there
is
a
growing
interest
studying
practices
patients,
optimal
have
not
clearly
established.
A
component
ASPs,
antiviral
(AVS),
specifically
targeting
cytomegalovirus
(CMV),
more
recently
described.
Understanding
AVS
opportunities
interventions
particularly
important
recipients,
given
morbidity
mortality
associated
with
viral
infections,
challenging
clinical
syndromes,
ultrasensitive
molecular
diagnostic
assays,
resistance,
costs
disease
medications,
as
well
drug
toxicities.
This
review
highlights
CMV,
EBV,
HSV,
VZV,
SARS-CoV-2,
respiratory
syncytial
virus,
BK
polyomavirus
patients.
Язык: Английский