Spotted Fever Group Rickettsia spp. Molecular and Serological Evidence among Colombian Vectors and Animal Hosts: A Historical Review

Insects, Год журнала: 2024, Номер 15(3), С. 170 - 170

Опубликована: Март 2, 2024

Spotted fever group Rickettsia spp. (SFGR) are a large of tick-borne bacteria causing important emerging and re-emerging diseases that affect animals humans. While SFGR found worldwide, lack surveillance misdiagnosis particularly South American countries. Colombia is high burdened country in America, yet rickettsioses not deemed nationally reportable condition limiting disease-specific public health resources. As mortality rates for one pathogen species, there great need to better understand the epidemiological ecological factors increase transmission risk regionally. This literature review provides an overview Colombia-based studies connecting knowledge about both vectors hosts.

Язык: Английский

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A Comparison of the Clinical and Epidemiological Profile of Rocky Mountain Spotted Fever with Dengue and COVID-19 in Hospitalized Children, Sonora, México, 2015–2022

Tropical Medicine and Infectious Disease, Год журнала: 2025, Номер 10(1), С. 20 - 20

Опубликована: Янв. 14, 2025

Rocky Mountain spotted fever (RMSF) is a challenge for physicians because the disease can mimic other endemic febrile illnesses, such as dengue and COVID-19. The comparison of their main clinical epidemiological manifestations in hospitalized children help identify characteristics that improve empirical suspicion timely therapeutic interventions. A cross-sectional study was conducted on series patients aged 0 to 18 years, between 2015 2022, with diagnosis RMSF, dengue, or Data were retrieved from medical records. Subjects categorized RMSF (group I) COVID-19 II). Descriptive statistics used, differences evaluated using Student's t-test chi-squared test. 305 subjects studied, 252 (82.6%) group I. both groups presented fever, myalgias, arthralgias, rash, but exposure ticks distinguished fatality rate (21.0%) I higher than II (3.8%). Although rash are common all three they more prevalent RMSF. In presence symptoms, history tick guide decisions regions where diseases endemic.

Язык: Английский

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Comprehensive insights into leishmaniasis: From etiopathogenesis to a novel therapeutic approach

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107535 - 107535

Опубликована: Апрель 1, 2025

Язык: Английский

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Rickettsia spp. and Anaplasmataceae in Ticks From Domestic Animals in Northern Colombia

Zoonoses and Public Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Tick-borne diseases have a significant impact on public and animal health represent considerable financial burden livestock farming. However, in many regions of Latin America, comprehensive epidemiological data, including species identification, geographical distribution molecular profiling ticks their associated pathogens, remain scarce. The aims the present study were: 1) to establish tick collected from domestic animals 2) molecularly characterise rickettsial bacteria department Atlántico, area Caribe, Colombia. Between January 2021 March 2022, were 216 cattle 72 sympatric (38 dogs, 31 equids 3 goats) 28 farms. Specimens identified grouped into 297 pools. Molecular detection characterisation pathogens carried out by targeting partial gltA, ompA, ompB 16S rRNA genes Rickettsia 23S Anaplasmataceae. A total 1541 collected, four belonging genera Rhipicephalus, Dermacentor Amblyomma identified. 137 288 (47.6%) infested with mean infection rate 9.7 ± SD 6.8 per animal. spp. Anaplasmataceae DNA detected 2.7% (MIR: 0.5%) 15.5% 0.3%) pools, respectively. obtained sequences showed high nucleotide identity (99%-100%) Candidatus colombiensis, Anaplasma marginale, platys, Ehrlichia canis minasensis. Our data first description nitens patinoi Atlantic region Colombian Caribbean. Considering risk that for health, monitoring control programmes are necessary prevent spread tick-borne pathogenic humans.

Язык: Английский

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Detection of Rickettsia spp. in questing ticks (Acari: Ixodidae) from forest fragments adjacent to agricultural and livestock farms in Casanare, Colombia

Parasitology Research, Год журнала: 2025, Номер 124(4)

Опубликована: Апрель 1, 2025

Abstract This study aimed to describe the diversity of ixodid tick species in rural forest areas Yopal and Aguazul, Department Casanare, Colombia, evaluate presence tick-borne Rickettsia sp., potentially impacting animal human health. A cross-sectional was conducted on questing ticks collected from forested farm that keep livestock and/or conduct agricultural activities. All were subjected DNA extraction tested by PCR amplifying fragments three rickettsial genes: gltA , htrA ompA . total 852 individual (larvae, nymphs, adults) 15 additional larvae clusters identified as Amblyomma mixtum cf parvum dissimile spp., Dermacentor spp. organisms detected 7.0% (16/230) larvae, 0.2% (1/488) 1.5% (2/134) adults. “ Candidatus colombianensi” amblyommatis 1.52% (13/852) 0.47% (4/852) ticks, respectively. In addition, a novel genotype, sp. genotype Yopal, phylogenetically closest canadensis, two A. males. Several found areas, suggesting need for an in-depth nonspecific acute tropical febrile illness Casanare across Colombia. Priority future studies include investigating molecular, clinical, epidemiological features presentation possible participation Ca R. colombianensi,” ” understand their role rickettsiosis region.

Язык: Английский

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Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2154 - 2154

Опубликована: Авг. 25, 2023

In Colombia, tropical febrile illnesses represent one of the most important causes clinical attention. Febrile in tropics are mainly zoonotic and have a broad etiology. The Colombian surveillance system monitors some notifiable diseases. However, several etiologies not monitored by this system. present review, we describe eleven different that but scientific, historical, contemporary data confirm or suggest their presence regions country: Anaplasma, Arenavirus, Bartonella, relapsing fever group Borrelia, Coxiella burnetii, Ehrlichia, Hantavirus, Mayaro virus, Orientia, Oropouche Rickettsia. These could generate risk for local population, travelers, immigrants, due to which they should be included mandatory notification system, considering importance public health.

Язык: Английский

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Emerging bacterial infectious diseases/pathogens vectored by human lice

Travel Medicine and Infectious Disease, Год журнала: 2023, Номер 55, С. 102630 - 102630

Опубликована: Авг. 9, 2023

Human lice have always been a major public health concern due to their vector capacity for louse-borne infectious diseases, like trench fever, relapsing and epidemic which are caused by Bartonella quintana, Borrelia recurrentis, Rickettsia prowazekii, respectively. Those diseases currently re-emerging in the regions of poor hygiene, social poverty, or wars with life-threatening consequences. These also outbreaks among populations jails refugee camps. In addition, antibodies DNAs those pathogens steadily detected homeless populations. Importantly, more bacterial human lice, some transmitted laboratories. Here, we provide comprehensive review update on diseases/bacterial pathogens.

Язык: Английский

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Molecular survey of Rickettsia spp. in ticks infesting wild animals in six departments in Colombia

Ticks and Tick-borne Diseases, Год журнала: 2024, Номер 15(6), С. 102381 - 102381

Опубликована: Июль 8, 2024

Ticks are a globally distributed group of hematophagous ectoparasites that parasitize terrestrial vertebrates such as amphibians, reptiles, birds, and mammals. vectors reservoirs pathogens play an important role in wildlife human health. Rickettsia is one the bacteria transmitted by ticks, which some pathogenic species can cause rickettsiosis, zoonotic disease serious harm to humans animals. More information necessary on interactions between ticks despite fifty-seven already identified Colombia. The objective present study was determine associations parasitizing genus six departments One hundred eighty-five (80 larvae, 78 nymphs, 27 adults) were collected from 55 (amphibians, mammals, reptiles). Nine tick identified, bellii, felis, 'Candidatus colombianensi' parkeri detected. Our results contribute current knowledge tick-associated rickettsiae their transmission dynamics.

Язык: Английский

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First isolation of Rickettsia amblyommatis from Amblyomma mixtum in Colombia

Parasites & Vectors, Год журнала: 2023, Номер 16(1)

Опубликована: Сен. 20, 2023

Rickettsiae are obligate intracellular Gram-negative bacteria that the causative agent of rickettsioses and spread to vertebrate hosts by arthropods. There no previous reports isolation Rickettsia amblyommatis for Colombia.A convenience sampling was executed in three departments Colombia direct collection adult ticks on domestic animals or over vegetation. Ticks were screened presence spp. real-time polymerase chain reaction (qPCR) amplifying citrate synthase gene (gltA), positive sample processed further molecular characterization conventional PCR. The absolute relative frequencies calculated several tick species variables. All products from PCR purified sequenced Sanger technique. Representative sequences 18 downloaded GenBank. Consensus phylogenetic trees constructed gltA, ompB, ompA, htrA genes with 1000 replicates, calculating bootstrap values through maximum likelihood method generalized time reversible substitution model MEGA 7.0 software program.One female Amblyomma mixtum collected vegetation amplified qPCR indicating a frequency 1.6% (1/61) spp.Sequence analysis rickettsial isolate this BLASTn showed 100% identity gltA (340 base pairs [bp]), 99.87% ompB (782 bp), 98.99% (497 ompA (488 bp) R. amblyommatis. Concatenated confirmed these findings is grouped other cajennense complex Panama Brazil within clade.This paper describes early identification strain A. Colombia.

Язык: Английский

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Antibody Seroprevalence to Spotted Fever Group Rickettsiae in Miraflores, Colombia: A Cross-Sectional Study in Humans and Dogs

American Journal of Tropical Medicine and Hygiene, Год журнала: 2024, Номер 110(6), С. 1245 - 1252

Опубликована: Апрель 9, 2024

Tick-borne disease burdens are increasing globally, impacting mostly rural and vulnerable communities. Among the most important emerging tick-borne pathogens Rickettsia species within spotted fever group (SFGR) because of their genetic diversity high lethality rate. Colombia is highly affected by SFGR despite not being reportable diseases; thus, research clinical management neglected. Although some departments have demonstrated seroprevalence rates, in others, such as Boyacá Department, unknown. Rickettsioses been described since 1943, conversations with local physicians raised suspicions recent undiagnosed compatible rickettsiosis areas department, warranting epidemiological investigation. Using biobanked human canine samples from a previous 2021 vector-borne study Miraflores municipality, Boyacá, we had an opportunity to unearth SFGR's exposure region. Samples were evaluated using IgG indirect fluorescent assays against complemented survey questionnaires evaluating associated factors. Findings yielded first-time serological evidence 26.5% among dogs 20.4% humans. Human dog seroprevalences positively associated, suggesting presence domestic transmission. Owning greater number animals (prevalence ratio adjusted for all measured factors [aPR], 1.52) living near crop fields (aPR, 7.77) increased likelihood household seropositivity. Our findings consistent literature Colombia, uncovering suspected region where endemic. Future studies warranted continue defining high-risk determine public health intervention plans.

Язык: Английский

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