Ultrasonics Sonochemistry, Год журнала: 2024, Номер 110, С. 107051 - 107051

Опубликована: Авг. 31, 2024

Acoustic cavitation plays a critical role in various biomedical applications. However, uncontrolled can lead to undesired damage healthy tissues. Therefore, real-time monitoring and quantitative evaluation of dynamics is essential for understanding underlying mechanisms optimizing ultrasound treatment efficiency safety. The current research addressed the limitations traditionally used detection methods by developing introduced an adaptive time-division multiplexing passive imaging (PCI) system integrated into commercial diagnostic platform. This new method combined with B-mode imaging, allowing simultaneous visualization progress 2D dosage within targeted area. An improved delay-and-sum (DAS) algorithm, optimized minimum variance (MV) beamformer, utilized minimize side lobe effect improve axial resolution typically associated PCI. In additional visualize quantitatively assess activities generated under varied acoustic pressures microbubble concentrations, this was specifically applied perform thrombolysis mediated different solutions, e.g., saline, nanodiamond (ND) nitrogen-annealed (N-AND). aims bridge gap between laboratory-based systems spatiotemporal demands practical uses. Results indicate that could offer useful tool comprehensive evaluating cavitation-mediated effects (e.g., thrombolysis), providing valuable insights in-depth optimization

Язык: Английский