Urachal Carcinomas: A Comprehensive Systematic Review and Meta-analysis
International braz j urol,
Год журнала:
2025,
Номер
51(3)
Опубликована: Апрель 29, 2025
This
systematic
review
and
meta-analysis
aim
to
consolidate
current
evidence
on
the
diagnosis,
epidemiology,
treatment
of
urachal
carcinoma,
a
rare
malignancy
with
limited
data.
A
search
PubMed/MEDLINE
was
conducted
up
September
2024
identify
studies
involving
patients
reporting
clinical
epidemiological
characteristics,
diagnostic
strategies,
histopathological
findings,
tumor
staging,
modalities,
oncological
outcomes.
Extracted
data
were
systematically
synthesized,
statistical
analyses,
including
single-arm
meta-analysis,
performed
comprehensively
evaluate
Our
study
includes
1,901
cases
carcinoma
from
50
studies.
The
findings
support
oncologic
advantage
en-bloc
resection
umbilectomy
in
localized
disease,
demonstrating
improved
survival
outcomes
reduced
recurrence
rates.
In
adjuvant
setting,
those
receiving
cisplatin-based
therapy
presented
best
response,
65.73%
no
disease
progression;
similarly,
metastatic
regimens
seem
have
better
responses
disease.
estimated
5-year
overall
rate
51%
(95%
CI:
0.49-0.54).
Tumor
documented
35%
0.25-0.45),
local
occurring
28%
0.18-0.38),
average
time
27.6
months.
provides
most
comprehensive
date,
providing
guide
decisions.
It
underscores
benefits
specific
chemotherapeutic
regimens.
Emerging
alternative
therapies
also
show
potential,
highlighting
need
for
further
research
optimize
patient
Язык: Английский
Multiparametric MRI in Era of Artificial Intelligence for Bladder Cancer Therapies
Cancers,
Год журнала:
2023,
Номер
15(22), С. 5468 - 5468
Опубликована: Ноя. 18, 2023
This
review
focuses
on
the
principles,
applications,
and
performance
of
mpMRI
for
bladder
imaging.
Quantitative
imaging
biomarkers
(QIBs)
derived
from
are
increasingly
used
in
oncological
including
tumor
staging,
prognosis,
assessment
treatment
response.
To
standardize
acquisition
interpretation,
an
expert
panel
developed
Vesical
Imaging–Reporting
Data
System
(VI-RADS).
Many
studies
confirm
standardization
high
degree
inter-reader
agreement
to
discriminate
muscle
invasiveness
cancer,
supporting
VI-RADS
implementation
routine
clinical
practice.
The
standard
MRI
sequences
scoring
anatomical
imaging,
T2w
images,
physiological
with
diffusion-weighted
(DW-MRI)
dynamic
contrast-enhanced
(DCE-MRI).
Physiological
QIBs
analysis
DW-
DCE-MRI
data
radiomic
image
features
extracted
images
play
important
role
cancer.
current
development
AI
tools
analyzing
their
potential
impact
surveyed.
architectures
often
implemented
based
convolutional
neural
networks
(CNNs),
focusing
narrow/specific
tasks.
application
can
substantially
workflows;
example,
manual
segmentation,
which
demands
time
commitment
has
variability,
be
replaced
by
autosegmentation
tool.
use
is
projected
drive
field
toward
personalized
management
cancer
patients.
Язык: Английский
Preoperative accuracy of diagnostic evaluation of urachal carcinoma
Cancer Medicine,
Год журнала:
2023,
Номер
12(8), С. 9106 - 9115
Опубликована: Фев. 3, 2023
Abstract
Background
We
analyzed
the
clinical
data
of
patients
with
urachal
carcinoma
(UrC)
in
order
to
strengthen
urologists'
understanding
UrC
and
improve
preoperative
diagnosis.
Methods
The
37
admitted
our
hospital
from
October
2005
April
2022
were
retrospectively
analyzed,
40
urothelial
(UCa)
bladder
enrolled
as
control
group.
compared
imaging,
cystoscopy
immunohistochemistry,
serum
tumor
markers,
fluorescence
situ
hybridization
(FISH)
UCa
for
early
diagnosis
evaluation
diagnostic
accuracy.
Results
A
total
this
study,
including
30
males
seven
females,
a
median
age
52.00
(44.50–63.50)
years.
Imaging
suggest
that
grows
primarily
outside
cavity
is
found
middle
line
dome
or
anterior
wall
bladder.
There
was
significant
difference
location
between
group
(10.13
mm
vs.
−7.06
mm,
p
<
0.001).
Immunohistochemistry
revealed
CK20
CDX‐2
both
diffusely
strongly
positive.
β‐catenin
positive
cytoplasm
membrane,
but
negative
nuclear
staining.
Carcinoembryonic
antigen
(CEA)
carbohydrate
72‐4
(CA724)
expression
levels
significantly
higher
than
(
0.05).
In
UrC,
area
under
curve
(AUC)
CEA
combined
CA724
greatest.
FISH's
sensitivity
diagnosing
(5/7,
71.43%)
not
different
(71.43%
77.50%,
=
0.659).
examination
has
highest
specificity
among
accuracy
methods.
Conclusions
are
powerful
methods
UrC.
Serum
markers
may
assist
diagnosis,
prognosis,
monitoring.
Positive
urine
FISH
can
easily
misdiagnose
Язык: Английский
Evaluating residual tumor after neoadjuvant chemotherapy for muscle-invasive urothelial bladder cancer: diagnostic performance and outcomes using biparametric vs. multiparametric MRI
Cancer Imaging,
Год журнала:
2023,
Номер
23(1)
Опубликована: Ноя. 14, 2023
Abstract
Background
Neoadjuvant
chemotherapy
(NAC)
before
radical
cystectomy
is
standard
of
care
in
patients
with
muscle-invasive
bladder
cancer
(MIBC).
Response
assessment
after
NAC
important
but
suboptimal
using
CT.
We
assessed
MRI
without
vs.
intravenous
contrast
(biparametric
[BP]
multiparametric
[MP])
for
identifying
residual
disease
on
and
explored
its
prognostic
role.
Methods
Consecutive
MIBC
that
underwent
NAC,
MRI,
between
January
2000–November
2022
were
identified.
Two
radiologists
reviewed
BP-MRI
(T2
+
DWI)
MP-MRI
DWI
DCE)
tumor.
Diagnostic
performances
compared
receiver
operating
characteristic
curve
analysis.
Kaplan-Meier
curves
Cox
proportional-hazards
models
used
to
evaluate
association
disease-free
survival
(DFS).
Results
61
(36
men
25
women;
median
age
65
years,
interquartile
range
59–72)
included.
After
no
was
detected
pathology
19
(31.1%)
patients.
more
accurate
than
detecting
NAC:
area
under
the
=
0.75
(95%
confidence
interval
(CI),
0.62–0.85)
0.58
CI,
0.45–0.70;
p
0.043).
Sensitivity
identical
(65.1%;
95%
49.1–79.0)
specificity
higher
determining
disease:
77.8%
52.4–93.6)
38.9%
17.3–64.3),
respectively.
Positive
both
associated
worse
DFS:
hazard
ratio
(HR)
4.01
1.70–9.46;
0.002)
HR
5.13
2.66–17.13;
0.008),
Concordance
results
significantly
DFS.
Concordant
positive
(MRI+/pathology+)
showed
DFS
concordant
negative
(MRI-/pathology-)
(HR
8.75,
2.02–37.82;
0.004)
discordant
group
(MRI+/pathology-
or
MRI-/pathology+)
3.48
1.39–8.71;
0.014).
Conclusion
NAC.
A
better
outcomes,
providing
complementary
information
pathological
specimens.
Язык: Английский
Primary urachal leiomyosarcoma: a case report and literature review of clinical, pathological, and medical imaging features
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 17, 2023
Background
Urachal
tumors
are
exceedingly
rare,
and
adenocarcinoma
is
the
most
common
malignant
urachal
neoplasm.
Here,
an
especially
rare
patient
of
primary
leiomyosarcoma
from
our
hospital
was
reported,
only
five
patients
have
been
reported
thus
far
since
1981.
Case
description
A
24-year-old
man
admitted
due
to
urinary
tract
symptoms.
Both
urogenital
ultrasonography
contrast-enhanced
computed
tomography
showed
a
mass
at
dome
bladder.
Laparoscopic
surgical
resection
performed,
histopathologic
examination
confirmed
diagnosis
leiomyosarcoma.
No
recurrence
noted
after
one
half
years.
Conclusions
Because
located
in
extraperitoneal
space
Retzius
may
manifest
with
nonspecific
abdominal
or
symptoms,
early
definitive
preoperative
challenging.
Partial
cystectomy
complete
excision
urachus
recommended.
few
recorded,
clinical
outcomes
risks
difficult
assess.
Язык: Английский
Case series of urachal adenocarcinoma: Imaging features
Journal of Cancer Research and Therapeutics,
Год журнала:
2023,
Номер
20(3), С. 1057 - 1060
Опубликована: Апрель 4, 2023
ABSTRACT
Urachal
adenocarcinoma
is
an
unusual
and
aggressive
form
of
bladder
cancer
that
arises
from
urachus,
a
midline
fibrous
remnant
allantois.
Experience
with
diagnosing
them
limited
differentiating
urachal
other
pathologies
like
infected
cysts
may
be
difficult
at
times.
Differentials
anomalies
can
narrowed
down
by
proper
assessment
patient
demographics,
clinical
details,
lesion
morphology,
imaging
findings.
With
this
case
series
five
patients
adenocarcinoma,
we
have
tried
describing
their
manifestation
appearances.
Язык: Английский
Urachus adenocarcinoma mistaken for umbilical incision implant cancer after laparoscopic cholecystectomy: a case report
Pathology & Oncology Research,
Год журнала:
2023,
Номер
29
Опубликована: Дек. 22, 2023
Umbilical
incision
implant
cancer
after
LC
is
rare.
Elective
cholecystectomy
was
planned
for
a
49
years-old
female
patient
with
symptomatic
gallstones.
The
underwent
transumbilical
single-port
admission
to
our
hospital.
Gallbladder
specimens
were
obtained
directly
through
the
umbilical
puncture
hole,
and
histopathology
suggested
chronic
cholecystitis.
Three
months
surgery,
experienced
painful
induration
in
umbilicus.
We
initially
considered
scar
hyperplasia
complicated
pain,
used
drugs
treat
it
conservatively
without
taking
special
treatment
measures.
Six
LC,
pain
affected
her
quality
of
life,
requested
surgical
resection.
Preoperative
ultrasonography
abdominal
computerized
tomography
(CT)
revealed
nodular
changes
around
umbilicus
no
mass.
Local
resection
periumbilical
mass
performed,
pathological
confirmation
invasive
adenocarcinoma.
Subsequently,
repeat
enlargement
Postoperative
pathology
showed
at
enlarged
margin,
yet
center
excised
sent
Sun
Yat-sen
University
Cancer
Center
consultation
because
rare
nature
findings
associated
case.
After
consultation,
diagnosis
urachus
adenocarcinoma
confirmed
based
on
morphology,
immunohistochemistry,
specific
anatomical
location
tumor.
This
case
report
shown
that
when
there
persistent
navel
possibility
tumor
should
be
considered,
rather
than
simply
excluding
non-cancer
medical
history.
Язык: Английский