The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy DOI Creative Commons

Martina Milella,

Monica Rutigliano,

Savio Domenico Pandolfo

и другие.

Cells, Год журнала: 2025, Номер 14(10), С. 717 - 717

Опубликована: Май 15, 2025

Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, recurrence. These exhibit unique metabolic features that contribute their stemness survival in hostile microenvironments. Like non-stem cancer cells, CSCs primarily rely on glycolysis ATP production, akin the Warburg effect. However, also show increased dependence alternative pathways, such as oxidative phosphorylation (OXPHOS) fatty acid metabolism, which provide necessary energy building blocks therapy resistance. The plasticity of enables them adapt fluctuating nutrient availability hypoxic conditions within tumor. Recent studies highlight importance these shifts maintaining CSC phenotype promoting progression. model suggests small, metabolically adaptable drives growth can switch between mitochondrial enhancing under stress dormant states. Targeting metabolism offers promising therapeutic strategy; however, adaptability complicates eradication. A multi-targeted approach addressing various pathways is essential effective elimination, underscoring need further research into specific markers mechanisms distinguish from normal successful intervention.

Язык: Английский

Targeting the complement system: notes on therapeutic strategies for renal cancer DOI
Francesco Lasorsa,

Monica Rutigliano,

Martina Milella

и другие.

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

1
The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy DOI Creative Commons

Martina Milella,

Monica Rutigliano,

Savio Domenico Pandolfo

и другие.

Cells, Год журнала: 2025, Номер 14(10), С. 717 - 717

Опубликована: Май 15, 2025

Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, recurrence. These exhibit unique metabolic features that contribute their stemness survival in hostile microenvironments. Like non-stem cancer cells, CSCs primarily rely on glycolysis ATP production, akin the Warburg effect. However, also show increased dependence alternative pathways, such as oxidative phosphorylation (OXPHOS) fatty acid metabolism, which provide necessary energy building blocks therapy resistance. The plasticity of enables them adapt fluctuating nutrient availability hypoxic conditions within tumor. Recent studies highlight importance these shifts maintaining CSC phenotype promoting progression. model suggests small, metabolically adaptable drives growth can switch between mitochondrial enhancing under stress dormant states. Targeting metabolism offers promising therapeutic strategy; however, adaptability complicates eradication. A multi-targeted approach addressing various pathways is essential effective elimination, underscoring need further research into specific markers mechanisms distinguish from normal successful intervention.

Язык: Английский

Процитировано

0