EClinicalMedicine, Год журнала: 2024, Номер 79, С. 102962 - 102962
Опубликована: Дек. 6, 2024
Язык: Английский
Nature reviews. Immunology, Год журнала: 2023, Номер 23(10), С. 618 - 634
Опубликована: Июль 11, 2023
Язык: Английский
Процитировано
273
BMJ Medicine, Год журнала: 2023, Номер 2(1), С. e000385 - e000385
Опубликована: Фев. 1, 2023
To determine the effect of covid-19 vaccination, given before and after acute infection with SARS-CoV-2 virus, or a diagnosis long covid, on rates symptoms covid.Systematic review.PubMed, Embase, Cochrane trials, Europe PubMed Central (Europe PMC) for preprints, from 1 January 2020 to 3 August 2022.Trials, cohort studies, case-control studies reporting patients covid vaccination covid. Risk bias was assessed ROBINS-I tool.1645 articles were screened but no randomised controlled trials found. 16 observational five countries (USA, UK, France, Italy, Netherlands) identified that reported 614 392 patients. The most common studied fatigue, cough, loss sense smell, shortness breath, taste, headache, muscle ache, difficulty sleeping, concentrating, worry anxiety, memory confusion. 12 data 10 showed significant reduction in incidence covid: odds ratio developing one dose vaccine ranged 0.22 1.03; two doses, ratios 0.25-1; three 0.16; any dose, 0.48-1.01. Five infection, 0.38-0.91. high heterogeneity between precluded meaningful meta-analysis. failed adjust potential confounders, such as other protective behaviours missing data, thus increasing risk decreasing certainty evidence low.Current suggest vaccines might have therapeutic effects More robust comparative are needed, however, clearly effectiveness preventing treating covid.Open Science Framework https://osf.io/e8jdy.
Язык: Английский
Процитировано
248
Vaccine, Год журнала: 2023, Номер 41(11), С. 1783 - 1790
Опубликована: Фев. 8, 2023
Язык: Английский
Процитировано
214
International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(19), С. 12422 - 12422
Опубликована: Сен. 29, 2022
The coronavirus disease 2019 (COVID-19) is still in a global pandemic state. Some studies have reported that COVID-19 vaccines had protective effect against long COVID. However, the conclusions of on COVID were not consistent. This study aimed to systematically review relevant real world, and performed meta-analysis explore relationship between vaccination We searched PubMed, Embase, Web science, ScienceDirect from inception 19 September 2022. PICO (P: patients; I: intervention; C: comparison; O: outcome) was as follows: patients diagnosed with (P); (I); divided into vaccinated unvaccinated groups (C); outcomes occurrence COVID, well various symptoms (O). A fixed-effect model random-effects chosen based heterogeneity order pool value. results showed group 29% lower risk developing compared (RR = 0.71, 95% CI: 0.58-0.87,
Язык: Английский
Процитировано
162
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Май 22, 2023
Abstract Long COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic records available through COVID Cohort Collaborative characterize association between SARS-CoV-2 vaccination and diagnosis. Among patients with infection August 1, 2021 January 31, 2022, we defined two cohorts using distinct definitions COVID—a clinical diagnosis ( n = 47,404) previously described computational phenotype 198,514)—to compare unvaccinated individuals those complete vaccine series prior infection. Evidence was monitored June July depending on patients’ data availability. found that consistently associated lower odds rates high-confidence computationally derived adjusting sex, demographics, medical history.
Язык: Английский
Процитировано
107
BMJ, Год журнала: 2023, Номер unknown, С. e076990 - e076990
Опубликована: Ноя. 22, 2023
Abstract Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within recommended schedule) against post-covid-19 condition (PCC). Design Population based cohort study. Setting Swedish Covid-19 Investigation for Future Insights—a Epidemiology Approach using Register Linkage (SCIFI-PEARL) project, a register study in Sweden. Participants All adults (≥18 years) with registered between 27 December 2020 9 February 2022 (n=589 722) largest regions Individuals were followed from infection until death, emigration, vaccination, reinfection, PCC diagnosis (ICD-10 code U09.9), or end follow-up (30 November 2022), whichever came first. who had received at least one vaccine before considered vaccinated. Main outcome measure The was clinical PCC. Vaccine estimated Cox regressions adjusted age, sex, comorbidities (diabetes cardiovascular, respiratory, psychiatric disease), number healthcare contacts during 2019, socioeconomic factors, dominant virus variant time infection. Results Of 299 692 vaccinated individuals covid-19, 1201 (0.4%) follow-up, compared 4118 (1.4%) 290 030 unvaccinated individuals. any associated reduced risk (adjusted hazard ratio 0.42, 95% confidence interval 0.38 to 0.46), 58%. individuals, 21 111 only, 205 650 doses, 72 931 three more doses. dose, 21%, 59%, 73%, respectively. Conclusions results this suggest strong association receiving findings highlight importance reduce population burden
Язык: Английский
Процитировано
65
Infectious Diseases Now, Год журнала: 2023, Номер 53(5), С. 104688 - 104688
Опубликована: Фев. 28, 2023
Язык: Английский
Процитировано
57
Journal of Thrombosis and Haemostasis, Год журнала: 2023, Номер 21(8), С. 2020 - 2031
Опубликована: Май 11, 2023
Язык: Английский
Процитировано
52
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Фев. 10, 2023
Long COVID (LC), a type of post-acute sequelae SARS-CoV-2 infection (PASC), occurs after at least 10% infections, yet its etiology remains poorly understood. Here, we used multiple "omics" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global SARS-CoV-2-specific immunity from blood individuals with clear LC non-LC clinical trajectories, 8 months following prior receipt any vaccine. Our analysis focused on deep phenotyping T cells, which play important roles in against may also contribute COVID-19 pathogenesis. findings demonstrate that exhibit systemic inflammation immune dysregulation. This is evidenced by differences cell subset distribution ways imply ongoing responses, as well sex-specific perturbations cytolytic subsets. Individuals harbored increased frequencies CD4+ cells poised migrate inflamed tissues, exhausted CD8+ cells. They significantly higher levels antibodies, contrast individuals, exhibited mis-coordination between their B responses. RNAseq/scRNAseq Olink analyses similarly revealed dysregulatory mechanisms, along non-immune associated perturbations, LC. Collectively, our data suggest proper crosstalk the humoral cellular arms adaptive has broken down LC, this, perhaps context persistent virus, leads dysregulation, inflammation, symptoms this debilitating condition.
Язык: Английский
Процитировано
47
PEDIATRICS, Год журнала: 2024, Номер 153(4)
Опубликована: Янв. 16, 2024
Vaccination reduces the risk of acute coronavirus disease 2019 (COVID-19) in children, but it is less clear whether protects against long COVID. We estimated vaccine effectiveness (VE) COVID children aged 5 to 17 years.
Язык: Английский
Процитировано
30