An observational multi-centric COVID-19 sequelae study among health care workers

The Lancet Regional Health - Southeast Asia, Год журнала: 2022, Номер 10, С. 100129 - 100129

Опубликована: Дек. 13, 2022

India has seen more than 43 million confirmed cases of COVID-19 as April 2022, with a recovery rate 98.8%, resulting in large section the population including healthcare workers (HCWs), susceptible to develop post COVID sequelae. This study was carried out assess nature and prevalence medical sequelae following infection, risk factors, if any.This an observational, multicenter cross-sectional conducted at eight tertiary care centers. The consenting participants were HCWs between 12 52 weeks discharge after infection. Data on demographics, history, clinical features various symptoms collected through specific questionnaire.Mean age 679 eligible 31.49 ± 9.54 years. overall 30.34%, fatigue (11.5%) being most common followed by insomnia (8.5%), difficulty breathing during activity (6%) pain joints (5%). odds having any significantly higher among who had moderate severe (OR 6.51; 95% CI 3.46-12.23) lower males 0.55; 0.39-0.76). Besides these, other predictors for (≥45 years), presence comorbidity (especially hypertension asthma), category HCW (non-doctors vs doctors) hospitalisation due COVID-19.Approximately one-third experienced Severity illness, female gender, advanced age, co-morbidity significant factors sequelae.This work is part Indian Council Medical Research (ICMR)- Rational Use Medicines network. No additional financial support received from ICMR carry work, materials, writing, APC.

Язык: Английский

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Long COVID Risk and Pre-COVID Vaccination: An EHR-Based Cohort Study from the RECOVER Program

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Окт. 7, 2022

Characterizing the effect of vaccination on long COVID allows for better healthcare recommendations.

Язык: Английский

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Impact of COVID-19 vaccination in post-COVID cardiac complications

Vaccine, Год журнала: 2023, Номер 41(8), С. 1524 - 1528

Опубликована: Янв. 27, 2023

Язык: Английский

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SARS-CoV-2 vaccination may mitigate dysregulation of IL-1/IL-18 and gastrointestinal symptoms of the post-COVID-19 condition

npj Vaccines, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 5, 2024

Abstract The rapid development of safe and effective vaccines helped to prevent severe disease courses after SARS-CoV-2 infection mitigate the progression COVID-19 pandemic. While there is evidence that vaccination may reduce risk developing post-COVID-19 conditions (PCC), this effect depend on viral variant. Therapeutic effects post-infection have been discussed but data for individuals with PCC remains inconclusive. In addition, extremely rare side resemble heterogeneous phenotype. Here, we analyze plasma levels 25 cytokines directed antibodies in 540 or without relative one two mRNA-based vaccinations as well 20 uninfected month their initial vaccination. none naïve reported any persisting sequelae exhibited PCC-like dysregulation cytokines, detected lower IL-1β IL-18 patients ongoing who received at a median six months compared unvaccinated patients. This reduction correlated less frequent reporting gastrointestinal symptoms. These suggest might be beneficial subgroup displaying

Язык: Английский

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SARS-CoV-2-specific CD8 ⁺ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(39)

Опубликована: Сен. 16, 2024

Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity understudied. SARS-CoV-2-specific T cell responses are key importance for viral clearance COVID-19 recovery. However, long COVID, the establishment persistence cells far from clear, especially beyond 12 mo postinfection postvaccination. We defined ex vivo antigen-specific B their receptors (TCR) repertoires across 2 y people with COVID. Using 13 SARS-CoV-2 peptide–HLA tetramers, spanning 11 HLA allotypes, as well spike nucleocapsid probes, we tracked CD8 + CD4 B-cells individuals first infection through primary vaccination over 24 mo. The frequencies ORF1a- nucleocapsid-specific remained stable Spike-specific were boosted by vaccination, indicating immunization, fully recovered altered immunodominance hierarchy epitopes. Meanwhile, influenza-specific mo, suggesting no bystander-activation. Compared total populations, enriched central memory phenotype, although proportion decreased acute illness. Importantly, TCR repertoire composition was maintained throughout including postvaccination, postinfection. Overall, understand recall responses, providing insights

Язык: Английский

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