Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 8, 2023
Developing
effective
vaccines
against
viral
infections
have
significant
impacts
on
development,
prosperity
and
well-being
of
human
populations.
Thus,
successful
such
as
smallpox
polio
vaccines,
promoted
global
societal
well-being.
In
contrast,
ineffective
may
fuel
arguments
that
retard
scientific
progress.
We
aim
to
stimulate
a
multilevel
discussion
how
develop
recent
future
pandemics
by
focusing
acquired
immunodeficiency
syndrome
(AIDS),
coronavirus
disease
(COVID)
other
infections.
appeal
harnessing
achievements
in
this
field
specifically
towards
cure
for
current
prevention
the
next
pandemics.
Among
these,
we
propose
apply
HIV
DNA
chromatin
format
–
an
end
product
aborted
integration
episomal
forms,
i.e.,
(cVacc),
elicit
epigenetic
silencing
memory
prevent
replication
infection.
Infezioni in Medicina,
Год журнала:
2023,
Номер
31(4)
Опубликована: Дек. 1, 2023
The
history
of
pandemics
spans
centuries
and
has
had
a
profound
impact
on
human
health,
societies,
economies.
Pandemics
have
caused
fear,
panic,
significant
morbidity
mortality
rates
throughout
history.
From
the
Athenian
Plague
in
430
BC
to
ongoing
COVID-19
pandemic,
infectious
diseases
posed
continuous
threat
global
health
systems.
transition
from
hunter-gatherer
societies
agrarian
communities,
increased
trade
interaction
between
humans
animals,
urbanization,
travel
rates,
growing
population
all
contributed
emergence
spread
diseases.
Climate
change
changes
land
use
further
affect
transmission
pathogens
distribution
disease-carrying
vectors.
Lessons
previous
include
importance
early
diagnosis
response,
cooperation
collaboration,
strengthened
healthcare
systems,
preparedness
planning,
public
education
communication,
research
development,
adaptability
flexibility
response
strategies.
These
lessons
emphasize
significance
timely
identification,
swift
action,
sharing
information
resources,
investing
infrastructure,
effective
advancements,
ability
adapt
measures
as
evolve.
In
addition,
pandemic
reinforced
need
for
collaborative
coordinated
future
pandemics.
Governments,
international
bodies,
organizations,
individuals
could
learn
past
apply
them
effectively
combat
mitigate
outbreaks.
By
prioritizing
recommendations
stated,
world
can
synergistically
protect
minimize
devastating
consequences
Population Medicine,
Год журнала:
2024,
Номер
6(January), С. 1 - 9
Опубликована: Янв. 24, 2024
1.
World
Health
Organization.
SP6
Sustainable
Financing
For
Immunization.
IA2023;
2020.
Accessed:
September
1,
2023.
https://www.immunizationagenda...
Google
Scholar
SLAS DISCOVERY,
Год журнала:
2024,
Номер
29(6), С. 100181 - 100181
Опубликована: Авг. 23, 2024
Severe
Acute
Respiratory
Syndrome
Coronavirus-2
(SARS-CoV-2,
SARS2)
is
responsible
for
the
COVID-19
pandemic
and
infections
that
continue
to
affect
lives
of
millions
people
worldwide,
especially
those
who
are
older
and/or
immunocompromised.
The
SARS2
main
protease
enzyme,
Mpro
(also
called
3C-like
protease,
3CLpro),
a
bona
fide
drug
target
as
evidenced
by
potent
inhibition
with
nirmatrelvir
ensitrelvir,
active
components
drugs
Paxlovid
Xocova,
respectively.
However,
existence
ensitrelvir-resistant
isolates
underscores
need
develop
next-generation
different
resistance
profiles
distinct
mechanisms
action.
Here,
we
report
results
high-throughput
screen
649,568
compounds
using
cellular
gain-of-signal
assay.
In
this
assay,
inhibits
expression
luciferase
reporter,
8,777
small
molecules
were
considered
hits
causing
gain
in
activity
3x
SD
above
sample
field
(6.8%
relative
100
µM
GC376).
Single
concentration
dose-response
experiments
confirmed
3,522/8,762
candidate
inhibitors.
parallel,
all
initial
screening
tested
peptide
cleavage
assay
purified
only
39/8,762
showed
inhibition.
Importantly,
19/39
(49%)
re-tested
positive
both
assays,
including
two
previously
reported
inhibitors,
demonstrating
efficacy
overall
strategy.
This
approach
led
rediscovery
known
inhibitors
such
calpain
inhibitor
II,
well
discovery
novel
provide
chemical
information
future
development
efforts.
Vaccines
are
the
most
effective
intervention
currently
available,
offering
protective
immunity
against
targeted
pathogens.
The
emergence
of
coronavirus
disease
2019
pandemic
has
prompted
rapid
development
and
deployment
lipid
nanoparticle
encapsulated,
mRNA-based
vaccines.
While
these
vaccines
have
demonstrated
remarkable
immunogenicity,
concerns
persist
regarding
their
ability
to
confer
durable
continuously
evolving
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
variants.
This
review
focuses
on
human
B
cell
responses
induced
by
SARS-CoV-2
mRNA
vaccination,
with
particular
emphasis
crucial
role
germinal
center
reactions
in
shaping
enduring
immunity.
Additionally,
we
explored
observations
immunological
imprinting
dynamics
recalled
pre-existing
following
variants
concern-based
booster
vaccination.
Insights
from
this
contribute
comprehensive
understanding
vaccination
humans,
thereby
refining
strategies
for
optimal
sustained
protection
Vaccines,
Год журнала:
2024,
Номер
12(7), С. 766 - 766
Опубликована: Июль 12, 2024
The
SARS-CoV-2
pandemic
and
the
emergence
of
novel
virus
variants
have
had
a
dramatic
impact
on
public
health
world
economy,
underscoring
need
for
detailed
studies
that
explore
high
efficacy
additional
vaccines
in
animal
models.
In
this
study,
we
confirm
pathogenicity
SARS-CoV-2/Leiden_008
isolate
(GenBank
accession
number
MT705206.1)
K18-hACE2
transgenic
mice.
Using
isolate,
show
vaccine
consisting
capsid
virus-like
particles
(cVLPs)
displaying
receptor-binding
domain
(RBD)
(Wuhan
strain)
induces
strong
neutralizing
antibody
responses
sterilizing
immunity
Furthermore,
demonstrate
vaccination
with
RBD-cVLP
protects
mice
from
both
lethal
infection
symptomatic
disease.
Our
data
also
indicate
immunization
significantly
reduces
inflammation
lung
pathology
associated
severe
disease
Additionally,
survival
naïve
animals
increases
when
sera
vaccinated
are
passively
transferred,
prior
to
dose.
Finally,
has
similar
antigen
composition
clinical
ABNCOV2
vaccine,
which
shown
non-inferiority
Comirnaty
mRNA
phase
I-III
trials.
Therefore,
our
study
provides
evidence
design
is
highly
immunogenic
confers
full
protection
against
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 4, 2024
Abstract
A
multiplexed,
lentivirus-based
pseudovirus
neutralisation
assay
(pVNT)
was
developed
for
high-throughput
measurement
of
neutralising
antibodies
(nAbs)
against
three
distinct
SARS-CoV-2
spike
variants.
Intra-assay
variability
minimised
by
optimising
the
plate
layout
and
determining
an
optimal
percentage
transduction
inoculum.
Comparison
monoclonal
antibody
EC
50
titres
between
single
multiplexed
pVNT
assays
showed
no
significant
differences,
indicating
reliability
assay.
Evaluation
convalescent
human
sera
confirmed
validity,
with
consistent
fold
drops
in
variant
pseudoviruses
relative
to
ancestral
strain
observed
across
assays.
This
provides
a
reliable
tool
assessing
nAb
responses
variants
could
be
used
accelerate
preclinical
vaccine
assessment
preparation
next
coronavirus
pandemic.
Influenza and Other Respiratory Viruses,
Год журнала:
2024,
Номер
18(10)
Опубликована: Окт. 1, 2024
ABSTRACT
Background
This
report
summarizes
the
discussions
and
conclusions
from
“Correlates
of
Protection
for
Next
Generation
Influenza
Vaccines:
Lessons
Learned
COVID‐19
Pandemic”
meeting,
which
took
place
in
Seattle,
USA,
March
1,
2023,
to
3,
2023.
Conclusions
Discussions
around
influenza
virus
correlates
protection
their
use
continued
where
discussion
had
been
left
off
2019.
While
there
was
not
much
progress
field
itself,
many
lessons
learned
during
coronavirus
disease
2019
(COVID‐19)
pandemic,
especially
importance
mucosal
immunity,
were
discussed
can
directly
be
applied
protection.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 8, 2023
Developing
effective
vaccines
against
viral
infections
have
significant
impacts
on
development,
prosperity
and
well-being
of
human
populations.
Thus,
successful
such
as
smallpox
polio
vaccines,
promoted
global
societal
well-being.
In
contrast,
ineffective
may
fuel
arguments
that
retard
scientific
progress.
We
aim
to
stimulate
a
multilevel
discussion
how
develop
recent
future
pandemics
by
focusing
acquired
immunodeficiency
syndrome
(AIDS),
coronavirus
disease
(COVID)
other
infections.
appeal
harnessing
achievements
in
this
field
specifically
towards
cure
for
current
prevention
the
next
pandemics.
Among
these,
we
propose
apply
HIV
DNA
chromatin
format
–
an
end
product
aborted
integration
episomal
forms,
i.e.,
(cVacc),
elicit
epigenetic
silencing
memory
prevent
replication
infection.
